פרסומים

Colloidal semiconductor quantum dots are robust emitters implemented in numerous prototype and commercial optoelectronic devices. However, active fluorescence colour tuning, achieved so far by electric-field-induced Stark effect, has been limited to a small spectral range, and accompanied by intensity reduction due to the electron–hole charge separation effect. Utilizing quantum dot molecules that manifest two coupled emission centres, we present a unique electric-field-induced instantaneous colour-switching effect. Reversible emission colour switching without intensity loss is achieved on a single-particle level, as corroborated by correlated electron microscopy imaging. Simulations establish that this is due to the electron wavefunction toggling between the two centres, induced by the electric field, and affected by the coupling strength. Quantum dot molecules manifesting two coupled emission centres may be tailored to emit distinct colours, opening the path for sensitive field sensing and colour-switchable devices such as a novel pixel design for displays or an electric-field-induced colour-tunable single-photon source.

The study of cardiac physiology is hindered by physiological differences between humans and small-animal models. Here we report the generation of multi-chambered self-paced vascularized human cardiac organoids formed under anisotropic stress and their applicability to the study of cardiac arrhythmia. Sensors embedded in the cardiac organoids enabled the simultaneous measurement of oxygen uptake, extracellular field potentials and cardiac contraction at resolutions higher than 10 Hz. This microphysiological system revealed 1 Hz cardiac respiratory cycles that are coupled to the electrical rather than the mechanical activity of cardiomyocytes. This electro-mitochondrial coupling was driven by mitochondrial calcium oscillations driving respiration cycles. Pharmaceutical or genetic inhibition of this coupling results in arrhythmogenic behaviour. We show that the chemotherapeutic mitoxantrone induces arrhythmia through disruption of this pathway, a process that can be partially reversed by the co-administration of metformin. Our microphysiological cardiac systems may further facilitate the study of the mitochondrial dynamics of cardiac rhythms and advance our understanding of human cardiac physiology. © 2023, The Author(s), under exclusive licence to Springer Nature Limited.

New mission-critical applications, such as autonomous vehicles and life-support systems, set a high bar for the reliability of modern microprocessors that operate in highly challenging conditions. However, while cutting-edge integrated circuit (IC) technologies have intensified microprocessors by providing remarkable reductions in the silicon area and power consumption, they also introduce new reliability challenges through the complex design rules they impose, creating a significant hurdle in the design process. In this paper, we focus on electromigration (EM), which is a crucial factor impacting IC reliability. EM refers to the degradation process of IC metal nets when used for both power supply and interconnecting signals. Typically, EM concerns have been addressed at the backend, circuit, and layout levels, where EM rules are enforced assuming extreme conditions to identify and resolve violations. This study presents new techniques that leverage architectural features to mitigate the effect of EM on the memory hierarchy of modern microprocessors. Architectural approaches can reduce the complexity of solving EM-related violations, and they can also complement and enhance common existing methods. In this study, we present a comprehensive simulation analysis that demonstrates how the proposed solution can significantly extend the lifetime of a microprocessor’s memory hierarchy with minimal overhead in terms of performance, power, and area while relaxing EM design efforts.

In photosynthesis, absorbed light energy transfers through a network of antenna proteins with near-unity quantum efficiency to reach the reaction center, which initiates the downstream biochemical reactions. While the energy transfer dynamics within individual antenna proteins have been extensively studied over the past decades, the dynamics between the proteins are poorly understood due to the heterogeneous organization of the network. Previously reported timescales averaged over such heterogeneity, obscuring individual interprotein energy transfer steps. Here, we isolated and interrogated interprotein energy transfer by embedding two variants of the primary antenna protein from purple bacteria, light-harvesting complex 2 (LH2), together into a near-native membrane disc, known as a nanodisc. We integrated ultrafast transient absorption spectroscopy, quantum dynamics simulations, and cryogenic electron microscopy to determine interprotein energy transfer timescales. By varying the diameter of the nanodiscs, we replicated a range of distances between the proteins. The closest distance possible between neighboring LH2, which is the most common in native membranes, is 25 Å and resulted in a timescale of 5.7 ps. Larger distances of 28 to 31 Å resulted in timescales of 10 to 14 ps. Corresponding simulations showed that the fast energy transfer steps between closely spaced LH2 increase transport distances by ∼15%. Overall, our results introduce a framework for well-controlled studies of interprotein energy transfer dynamics and suggest that protein pairs serve as the primary pathway for the efficient transport of solar energy.

The discovery of the Ti3C2Tx compounds (MXenes) a decade ago opened new research directions and valuable opportunities for high-rate energy storage applications. The unique ability of the MXenes to host various mono- and multivalent cations and their high stability in different electrolyte environments including aqueous, organic, and ionic liquid solutions, promoted the rapid development of advanced MXene-based electrodes for a large variety of applications. Unlike the vast majority of typical intercalation compounds, the electrochemical performance of MXene electrodes is strongly influenced by the presence of co-inserted solvent molecules, which cannot be detected by conventional current/potential electrochemical measurements. Furthermore, the electrochemical insertion of ions into MXene interspaces results in strong coupling with the intercalation-induced structural, dimensional, and viscoelastic changes in the polarized MXene electrodes. To shed light on the charging mechanisms of MXene systems and their associated phenomena, the use of a large variety of real-time monitoring techniques has been proposed in recent years. This review summarizes the most essential findings related to the charging mechanism of Ti3C2Tx electrodes and their potential induced structural and mechanical phenomena obtained by in situ investigations.

Archival discoveries reported in Notes and Queries in the past two years have identified the ‘M Streamer’ who narrates most of William Baldwin’s prose satire Beware the Cat (1561) with the real historical figure of Gregory Stremer, contradicting a long-held belief that Baldwin’s narrator was a fiction. The present note sheds another glint of light on Stremer’s London life. It further establishes him as a living person rather than a confection, and suggests that a connection to Westminster is possible after all, perhaps on precisely the ‘semi-formal or independent basis’ that Parsons conjectures.

The rise of emergency governance in global public health has driven a number of changes in this field. In this article, we investigate one of the practices of emergency governance – border screening – and identify a new form of screening that emerged in the UK during the 2014 Ebola epidemic in West Africa. Analysing the UK’s deployment of Ebola entry screening and the public debate that emerged around it, we show how this technology was constructed to identify potentially risky individuals, assess their risk level and pre-accelerate future response to potential cases. Engaging with Foucault’s notion of a ‘crisis of circulation’, we argue that this approach expresses a response to an emergency of circulation: the alarming prospect of a concrete threat with the potential to infiltrate the population through circulation systems. We show that entry screening, in this case, addresses such a problem by enabling, rather than …

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