Publications

2024
Zhang, Z. ; Ding, Z. ; Yang, J. ; Zhao, Y. ; Zhao, Z. ; Liu, C. ; Metanis, N. ; Zhao, J. . An Efficient Approach To Avicys Analogues Via Regio-And Stereoselective Hydrosulfuration Of Ynamides. Organic Chemistry Frontiers 2024.
Ghareeb, H. ; Li, C. Yi; Shenoy, A. ; Rotenberg, N. ; Shifman, J. M. ; Katoh, T. ; Sagi, I. ; Suga, H. ; Metanis, N. . Mirror-Image Random Nonstandard Peptide Integrated Discovery (Mi-Rapid) Technology Yields Highly Stable And Selective Macrocyclic Peptide Inhibitors For Matrix Metallopeptidase 7. Angewandte Chemie 2024. Abstract
Mirror Image RaPID Angewandte Chemie
Wang, C. ; Zhao, Z. ; Ghadir, R. ; Yang, D. ; Zhang, Z. ; Ding, Z. ; Cao, Y. ; Li, Y. ; Fassler, R. ; Reichmann, D. ; et al. Peptide And Protein Cysteine Modification Enabled By Hydrosulfuration Of Ynamide. ACS Central Science 2024, 10, 1742-1754. Abstract
peptide_and_protein_cysteine_modification_enabled_by_hydrosulfuration_of_ynamide.png
Laps, S. ; Metanis, N. . Organic Solvent Enhances Oxidative Folding Of Disulfide-Rich Proteins. Nature Chemistry 2024, 16, 680-681.
Zhao, Z. ; Laps, S. ; Gichtin, J. S. ; Metanis, N. . Selenium Chemistry For Spatio-Selective Peptide And Protein Functionalization. Nature Reviews Chemistry 2024, 8, 211–229. Abstract
Se Chemistry TOC
Weil-Ktorza, O. ; Dhayalan, B. ; Chen, Y. - S. ; Weiss, M. A. ; Metanis, N. . Se-Glargine: Chemical Synthesis Of A Basal Insulin Analogue Stabilized By An Internal Diselenide Bridge. ChemBioChem 2024, 25. Abstract
Se-Glargine ChemBioChem
2023
Gil, M. ; Khouri, L. ; Raurell, I. ; Rafael, D. ; Andrade, F. ; Abasolo, I. ; Schwartz, S. Jr; Martínez-Gómez, M. ; Salcedo, M. Teresa; Pericàs, J. Manuel; et al. Optimization Of Statin-Loaded Delivery Nanoparticles For Treating Chronic Liver Diseases By Targeting Liver Sinusoidal Endothelial Cells. Pharmaceutics 2023, 15, 2463.
Dardashti, R. N. ; Laps, S. ; Gichtin, J. S. ; Metanis, N. . The Semisynthesis Of A Nucleolar Human Selenoprotein H. Chemical Science 2023, 14, 12723-12729. Abstract
Seleno-H TOC
Weil-Ktorza, O. ; Despotovic, D. ; Fridmann-Sirkis, Y. ; Naveh-Tassa, S. ; Levy, Y. ; Metanis, N. ; Longo, L. M. . Functional Ambidexterity Of An Ancient Nucleic Acid-Binding Domain . 2023.
Chen, Y. S. ; Dhayalan, B. ; Yang, Y. ; Weil-Ktorza, O. ; Metanis, N. ; Weiss, M. A. . Se-Glargine ΙΙ. Native Function Of A Basal Insulin Analog Stabilized By An Internal Diselenide Bridge. 2023.
Ghareeb, H. ; Metanis, N. . Enhancing The Gastrointestinal Stability Of Salmon Calcitonin Through Peptide Stapling. Chemical Communications 2023, 59, 6682-6685. Abstract
calcitonin
Babu, T. ; Ghareeb, H. ; Basu, D. U. ; Schueffl, H. ; Theiner, D. S. ; Heffeter, P. P. ; Koellensperger, P. G. ; Metanis, P. N. ; Gandin, P. V. ; Ott, P. I. ; et al. Oral Anticancer Heterobimetallic PtIv&Minus;AuI Complexes Show High In Vivo Activity And Low Toxicity. Angew. Chemie Int. Ed. 2023, e202217233. Abstract
image
Shemesh, A. ; Ghareeb, H. ; Dharan, R. ; Levi-Kalisman, Y. ; Metanis, N. ; Ringel, I. ; Raviv, U. . Effect Of Tubulin Self-Association On Gtp Hydrolysis And Nucleotide Exchange Reactions. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 2023, 1871, 140869. Abstract
BBA
2022
Seal, M. ; Weil-Ktorza, O. ; Despotović, D. ; Tawfik, D. S. ; Levy, Y. ; Metanis, N. ; Longo, L. M. ; Goldfarb, D. . Peptide-Rna Coacervates As A Cradle For The Evolution Of Folded Domains. J. Am. Chem. Soc. 2022, 144, 14150-14160. Abstract
JACS 2022
Zhao, Z. ; Mousa, R. ; Metanis, N. . One-Pot Chemical Protein Synthesis Utilizing Fmoc-Masked Selenazolidine To Address The Redox Functionality Of Human Selenoprotein F. Chemistry a European Journal 2022, 28, e202200279.Abstract
TOC
2021
Radzinski, M. ; Oppenheim, T. ; Metanis, N. ; Reichmann, D. . The Cys Sense: Thiol Redox Switches Mediate Life Cycles Of Cellular Proteins. Biomolecules 2021, 11, 469. Abstract
Biomolecules 2021
Zhao, Z. ; Shimon, D. ; Metanis, N. . Chemoselective Copper-Mediated Radical Modification Of Selenocysteines In Peptides And Proteins. J. Am. Chem. Soc. 2021, 143, 12817-12824. Abstract
Sec Hydrazide Modification
Mousa, R. ; Hidmi, T. ; Pomyalov, S. ; Lansky, S. ; Khouri, L. ; Shalev, D. E. ; Shoham, G. ; Metanis, N. . Diselenide Crosslinks For Enhanced And Simplified Oxidative Protein Folding. Nature Communications Chemistry 2021, 4. Abstract
Se-Hir graphical
2020
Lahav, N. ; Rotem-Bamberger, S. ; Fahoum, J. ; Dodson, E. - J. ; Kraus, Y. ; Mousa, R. ; Metanis, N. ; Friedler, A. ; Schueler-Furman, O. . Phosphorylation Of The Wwox Protein Regulates Its Interaction With P73. ChemBioChem 2020, 21.
Ghareeb, H. ; Metanis, N. . The Thioredoxin System: A Promising Target For Cancer Drug Development. Chemistry a European Journal 2020, 26, 10175-10184. Abstract
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