Publications

2020
Zhao, Z. ; Metanis, N. . Utilizing Copper-Mediated Deprotection Of Selenazolidine For Cyclic Peptides Synthesis. Journal of Organic Chemistry 2020, 85, 1731-1739. Abstract
JOC 2020
2019
Mamidi, S. ; Mayer, D. ; Metanis, N. ; Veprintsev, D. ; Hurevich, M. ; Friedler, A. . A Targeted Approach For The Synthesis Of Multi-Phosphorylated Peptides: A Tool For Studying The Role Of Phosphorylation Patterns In Proteins. Organic & Biomolecular Chemistry 2019, 17, 9284–9290.
Zhao, Z. ; Metanis, N. . Copper-Mediated Selenazolidine Deprotection Enables One-Pot Chemical Synthesis Of Challenging Proteins. Angewandte Chemie International Edition 2019, 58, 14610-14614.Abstract

Highlit : One-Pot Chemical Synthesis of Proteins by CopperMediated Selenazolidine Deprotection 

URL: https://www.thieme-connect.com/products/ejournals/pdf/10.1055/s-0039-1691279.pdf

Metanis, N. ; Dardashti, R. N. ; Mousa, R. ; Ktorza, O. . Miklós Bodanszky Award Lecture: Selective Chalcogen Chemistry To Study Protein Science. Journal of Peptide Science 2019, 25, e3204.
Weil‐Ktorza, O. ; Rege, N. ; Lansky, S. ; Shalev, D. E. ; Shoham, G. ; Weiss, M. A. ; Metanis*, N. . Substitution Of An Internal Disulfide Bridge In Human Insulin By A Diselenide Enhances Its Foldability And Stability. Chemistry a European Journal 2019, 25, 8513-8521.Abstract
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Abbasi, R. ; Mousa, R. ; Dekel, N. ; Amartely, H. ; Danieli, T. ; Lebendiker, M. ; Levi‐Kalisman, Y. ; Shalev, D. E. ; Metanis, N. ; Chai, L. . The Bacterial Extracellular Matrix Protein Tapa Is A Two‐Domain Partially Disordered Protein. ChemBioChem 2019, 20, 355-359.Abstract
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2018
Mousa, R. ; Lansky, S. ; Shoham, G. ; Metanis, N. . Bpti Folding Revisited: Switching A Disulfide Into Methylene Thioacetal Reveals A Previously Hidden Path. Chemical Science 2018, 4, 4814-4820.Abstract
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Young Career Focus: Dr. Norman Metanis (Hebrew University Of Jerusalem, Israel). Synform 2018, 4, A53-A55.
2017
Mousa, R. ; Dardashti, R. N. ; Metanis, N. . Selenium And Selenocysteine In Protein Chemistry. Angewandte Chemie International Edition 2017, 56, 15818-15827.Abstract
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Mamidi, S. ; Mayer, D. ; Metanis, N. ; Veprintsev, D. ; Hurevich, M. ; Friedler, A. . A Combinatorial Approach For The Synthesis Of Multi-Phosphorylated Peptides: New Tool For Studying Phosphorylation Patterns In Proteins. bioRxiv 2017.
Dardashti, R. N. ; Metanis, N. . Revisiting Ligation At Selenomethionine: Insights Into Native Chemical Ligation At Selenocysteine And Homoselenocysteine. Bioorganic & Medicinal Chemistry 2017, 25, 4983-4989.Abstract
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Mousa, R. ; Reddy, P. S. ; Metanis, N. . Chemical Protein Synthesis Through Selenocysteine Chemistry. Synlett 2017, 28, 1389-1393.Abstract
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Chandra, K. ; Das, P. ; Metanis, N. ; Friedler, A. ; Reches, M. . Peptide Fibrils As Monomer Storage Of The Covalent Hiv-1 Integrase Inhibitor. Journal of Peptide Science 2017, 23, 117-121.Abstract
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Dery, L. ; Reddy, P. S. ; Dery, S. ; Mousa, R. ; Ktorza, O. ; Talhami, A. ; Metanis, N. . Accessing Human Selenoproteins Through Chemical Protein Synthesis. Chemical Science 2017, 8, 1922-1926.Abstract
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2016
Shoshan, M. S. ; Lehman, Y. ; Goch, W. ; Bal, W. ; Tshuva, E. Y. ; Metanis, N. . Selenocysteine Containing Analogues Of Atx-1 Based Peptides Protect Cells From Copper Ion Toxicity. Organic & Biomolecular Chemistry 2016, 14, 6979-6984.Abstract
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Chandra, K. ; Das, P. ; Mamidi, S. ; Hurevich, M. ; Iosub‐Amir, A. ; Metanis, N. ; Reches, M. ; Friedler, A. . Covalent Inhibition Of Hiv-1 Integrase By N-Succinimidyl Peptides. ChemMedChem 2016, 11, 1987-1994.Abstract
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Dardashti, R. N. ; Dery, L. ; Mousa, R. ; Dery, S. ; Reddy, P. S. ; Metanis, N. . The Chemistry Of Selenocysteine In Proteins. In Selenium: Its Molecular Biology and Role in Human Health; Hatfield, D. L. ; Schweizer, U. ; Tsuji, P. A. ; Gladyshev, V. N., Eds.; Springer, 2016; pp. 73-83.Abstract
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Reddy, P. S. ; Metanis, N. . Small Molecule Diselenide Additives For In Vitro Oxidative Protein Folding. Chemical Communications 2016, 52, 3336-3339.Abstract
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Reddy, P. S. ; Dery, S. ; Metanis, N. . Chemical Synthesis Of Proteins With Non-Strategically Placed Cysteines Using Selenazolidine And Selective Deselenization. Angewandte Chemie International Edition 2016, 128, 1004-1007.Abstract
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2015
Dery, S. ; Reddy, P. S. ; Dery, L. ; Mousa, R. ; Dardashti, R. N. ; Metanis, N. . Insights Into The Deselenization Of Selenocysteine Into Alanine And Serine. Chemical Science 2015, 6, 6207-6212.Abstract
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