Publications

2021
R. Fresia, Marangoni, P. , Burstyn-Cohen, T. , and Sharir, A. . 2021. “From Bite To Byte: Dental Structures Resolved At A Single-Cell Resolution”. Journal Of Dental Research.
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2020
KrasP34R and KrasT58I mutations induce distinct RASopathy phenotypes in mice
J.C. Wong, Perez-Mancera, P.A. , Huang, T.Q. , Kim, J. , Grego-Bessa, J. , Alzamora, M.D.P. , Kogan, S.C. , Sharir, A. , Keefe, S.H. , Morales, C.E. , Schanze, D. , Castel, P. , Hirose, K. , Huang, G.N. , Zenker, M. , Sheppard, D. , Klein, O.D. , Tuveson, D.A. , Braun, B.S. , and Shannon, K. . 2020. “KrasP34R And KrasT58I Mutations Induce Distinct Rasopathy Phenotypes In Mice”. Jci Insight, 5, 21.
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2019
A large pool of actively cycling progenitors orchestrates self-renewal and injury repair of an ectodermal appendage
A. Sharir, Marangoni, P. , Zilionis, R. , Wan, M. , Wald, T. , Hu, J.K. , Kawaguchi, K. , Castillo-Azofeifa, D. , Epstein, L. , Harrington, K. , Pagella, P. , Mitsiadis, T. , Siebel, C.W. , Klein, A.M. , and Klein, O.D. . 2019. “A Large Pool Of Actively Cycling Progenitors Orchestrates Self-Renewal And Injury Repair Of An Ectodermal Appendage”. Nature Cell Biology, 21, 9, Pp. 1102-1112.
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2018
Isl1 mediates mesenchymal expansion in the developing external genitalia via regulation of Bmp4, Fgf10 and Wnt5a
S.T. Ching, Infante, C.R. , Du, W. , Sharir, A. , Park, S. , Menke, D.B. , and Klein, O.D. . 2018. “Isl1 Mediates Mesenchymal Expansion In The Developing External Genitalia Via Regulation Of Bmp4, Fgf10 And Wnt5A”. Human Molecular Genetics, 27, 1, Pp. 107-119.
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Mechanoresponsive stem cells acquire neural crest fate in jaw regeneration
R.C. Ransom, Carter, A.C. , Salhotra, A. , Leavitt, T. , Marecic, O. , Murphy, M.P. , Lopez, M.L. , Wei, Y. , Marshall, C.D. , Shen, E.Z. , Jones, R.E. , Sharir, A. , Klein, O.D. , Chan, C.K.F. , Wan, D.C. , Chang, H.Y. , and Longaker, M.T. . 2018. “Mechanoresponsive Stem Cells Acquire Neural Crest Fate In Jaw Regeneration”. Nature, 563, 7732, Pp. 514-521.
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2016
A. Sharir and Klein, O.D. . 2016. “Watching A Deep Dive: Live Imaging Provides Lessons About Tooth Invagination”. Journal Of Cell Biology, 214, 6.
Human iPS cell-derived neurons uncover the impact of increased ras signaling in costello syndrome
G.E. Rooney, Goodwin, A.F. , Depeille, P. , Sharir, A. , Schofield, C.M. , Yeh, E. , Roose, J.P. , Klein, O.D. , Rauen, K.A. , Weiss, L.A. , and Ullian, E.M. . 2016. “Human Ips Cell-Derived Neurons Uncover The Impact Of Increased Ras Signaling In Costello Syndrome”. Journal Of Neuroscience, 36, 1, Pp. 142-152.
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2015
Continuously Growing Rodent Molars Result from a Predictable Quantitative Evolutionary Change over 50 Million Years
V. Tapaltsyan, Eronen, J.T. , Lawing, A.M. , Sharir, A. , Janis, C. , Jernvall, J. , and Klein, O.D. . 2015. “Continuously Growing Rodent Molars Result From A Predictable Quantitative Evolutionary Change Over 50 Million Years”. Cell Reports, 11, 5, Pp. 673-680.
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Isometric scaling in developing long bones is achieved by an optimal epiphyseal growth balance
T. Stern, Aviram, R. , Rot, C. , Galili, T. , Sharir, A. , Achrai, N.K. , Keller, Y. , Shahar, R. , and Zelzer, E. . 2015. “Isometric Scaling In Developing Long Bones Is Achieved By An Optimal Epiphyseal Growth Balance”. Plos Biology, 13, 8.
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Loss of osteoblast Runx3 produces severe congenital osteopenia
O. Bauer, Sharir, A. , Kimura, A. , Hantisteanu, S. , Takeda, S. , and Groner, Y. . 2015. “Loss Of Osteoblast Runx3 Produces Severe Congenital Osteopenia”. Molecular And Cellular Biology, 35, 7, Pp. 1097-1109.
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2014
Abnormal ras signaling in costello syndrome (CS) negatively regulates enamel formation
A.F. Goodwin, Tidyman, W.E. , Jheon, A.H. , Sharir, A. , Zheng, X. , Charles, C. , Fagin, J.A. , McMahon, M. , Diekwisch, T.G.H. , Ganss, B. , Rauen, K.A. , and Klein, O.D. . 2014. “Abnormal Ras Signaling In Costello Syndrome (Cs) Negatively Regulates Enamel Formation”. Human Molecular Genetics, 23, 3, Pp. 682-692.
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2013
A temporary decrease in mineral density in perinatal mouse long bones
A. Sharir, Milgram, J. , Dubnov-Raz, G. , Zelzer, E. , and Shahar, R. . 2013. “A Temporary Decrease In Mineral Density In Perinatal Mouse Long Bones”. Bone, 52, 1, Pp. 197-205.
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Tendon-bone attachment unit is formed modularly by a distinct pool of Scx-and Sox9-positive progenitors
E. Blitz, Sharir, A. , Akiyama, H. , and Zelzer, E. . 2013. “Tendon-Bone Attachment Unit Is Formed Modularly By A Distinct Pool Of Scx-And Sox9-Positive Progenitors”. Development (Cambridge), 140, 13, Pp. 2680-2690.
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2011
Bone mineralization proceeds through intracellular calcium phosphate loaded vesicles: A cryo-electron microscopy study
J. Mahamid, Sharir, A. , Gur, D. , Zelzer, E. , Addadi, L. , and Weiner, S. . 2011. “Bone Mineralization Proceeds Through Intracellular Calcium Phosphate Loaded Vesicles: A Cryo-Electron Microscopy Study”. Journal Of Structural Biology, 174, 3, Pp. 527-535.
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The canine baculum: The structure and mechanical properties of an unusual bone
A. Sharir, Israeli, D. , Milgram, J. , Currey, J.D. , Monsonego-Ornan, E. , and Shahar, R. . 2011. “The Canine Baculum: The Structure And Mechanical Properties Of An Unusual Bone”. Journal Of Structural Biology, 175, 3, Pp. 451-456.
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High resolution 3D imaging of Ex-Vivo biological samples by micro CT
A. Sharir, Ramniceanu, G. , and Brumfeld, V. . 2011. “High Resolution 3D Imaging Of Ex-Vivo Biological Samples By Micro Ct”. Journal Of Visualized Experiments, 52.
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Muscle force regulates bone shaping for optimal loadbearing capacity during embryogenesis
A. Sharir, Stern, T. , Rot, C. , Shahar, R. , and Zelzer, E. . 2011. “Muscle Force Regulates Bone Shaping For Optimal Loadbearing Capacity During Embryogenesis”. Development, 138, 15, Pp. 3247-3259.
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Tendon homeostasis: The right pull
A. Sharir and Zelzer, E. . 2011. “Tendon Homeostasis: The Right Pull”. Current Biology, 21, 12.
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2010
Bone vascularization and trabecular bone formation are mediated by PKBalpha/Akt1 in a gene-dosage-dependent manner: In vivo and ex vivo MRI
K. Vandoorne, Magland, J. , Plaks, V. , Sharir, A. , Zelzer, E. , Wehrli, F. , Hemmings, B.A. , Harmelin, A. , and Neeman, M. . 2010. “Bone Vascularization And Trabecular Bone Formation Are Mediated By Pkbalpha/Akt1 In A Gene-Dosage-Dependent Manner: In Vivo And Ex Vivo Mri”. Magnetic Resonance In Medicine, 64, 1, Pp. 54-64.
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The influence of severe prolonged exercise restriction on the mechanical and structural properties of bone in an avian model
A. Shipov, Sharir, A. , Zelzer, E. , Milgram, J. , Monsonego-Ornan, E. , and Shahar, R. . 2010. “The Influence Of Severe Prolonged Exercise Restriction On The Mechanical And Structural Properties Of Bone In An Avian Model”. Veterinary Journal, 183, 2, Pp. 153-160.
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