פרסומים

Dynamic group coordination facilitates adaptive division of labor in response to group-level changes. Yet, little is known about how it can be operationalized in online collaborations among individuals with limited information about each other. We hypothesized that simple social information about the task distribution of others can elicit emergent task allocation. We conducted an online experiment where participants analyze images of a polluted canal by freely switching between two tasks: creating keyword-based tags for images and categorizing existing tags. During the task execution, we presented experimentally manipulated information about the contrasting group-level task distributions. Participants did not change the effort allocation between the tasks when they were notified that the group deficits workers in the task they intrinsically prefer. By contrast, they allocated more effort to the less preferred task than they would intrinsically do when their intrinsic effort allocation counterbalances the current distribution of workers in the group. Such behavioral changes were observed more strongly among those with higher skills in the less preferred task. Our results demonstrate the possibility of optimizing group coordination through design interventions at the individual level that lead to spontaneous adaption of division of labor at the group level. When participants were provided information about the group-level task distribution, they tend to allocate more effort to the task against their intrinsic preference.

In today's developed world, the ability of a city to generate good experiences for its residents and visitors is a main aspect of its attractiveness. A good city is considered to be one in which people feel secure, relaxed, and happy. This article explores the factors that influence the subjective momentary experiences of individuals in the city, while focusing on the impact of spatial variables on these experiences; 91 students living in Jerusalem, Israel, were asked to repeatedly self-report four dimensions of episodic experience, namely, sense of security, happiness, annoyance, and sense of comfort. Reports were sent in real time using a smartphone application during an eight-month period. The results, based on over 5000 experience samples, indicate that subjective momentary experiences, particularly sense of comfort and sense of security, are highly influenced by situational variables and environmental characteristics including type of activity and environment, place characteristics, and company. Surp...

In today's developed world, the ability of a city to generate good experiences for its residents and visitors is a main aspect of its attractiveness. A good city is considered to be one in which people feel secure, relaxed, and happy. This article explores the factors that influence the subjective momentary experiences of individuals in the city, while focusing on the impact of spatial variables on these experiences; 91 students living in Jerusalem, Israel, were asked to repeatedly self-report four dimensions of episodic experience, namely, sense of security, happiness, annoyance, and sense of comfort. Reports were sent in real time using a smartphone application during an eight-month period. The results, based on over 5000 experience samples, indicate that subjective momentary experiences, particularly sense of comfort and sense of security, are highly influenced by situational variables and environmental characteristics including type of activity and environment, place characteristics, and company. Surp...

This dictionary was created as part of the INFOCORE research project, coordinated by Romy Fröhlich, Ludwig Maximilian University Munich;as part of the work of the Methodological Working Group: Content Analysis, headed by Christian Baden, The Hebrew University of Jerusalem;which was a joint effort of Work Package 5: Social Media, headed by Dimitra Dimitrakopoulou, Massachusetts Institute of Technology; Work Package 6: Strategic Communication, headed by Romy Fröhlich, Ludwig Maximilian University Munich; Work Package 7: Journalistic Transformation, headed by Keren Tenenboim-Weinblatt, The Hebrew University of Jerusalem; and Work Package 8: Parliamentary Discourse, headed by Rosa Berganza Conde, King Juan Carlos University Madrid.The INFOCORE Dictionary includes…3,738 measured concepts in conflict-related discourse, ordered into four main groups: Semantic concepts (IDs 1####); Actors (2####); Times/Events (3####); Locations (4####)8 languages: Albanian, Arabic, English, French, German, Hebrew, Macedonian, and Serbian78,984 unique search phrases with 191,408 disambiguation criteria (Albanian: 9,595 + 22,915; Arabic: 9,592 + 10,816; English: 10,464 + 38,459; French: 7,476 + 19,470; German: 14,054 + 46,208; Hebrew: 11,708 + 14,853; Macedonian: 7,727 + 18,450; Serbian: 8,368 + 20,237)The INFOCORE Dictionary is built for use in conjunction with the jamcode coding script available on Github, and the AmCAT open source text analysis platform.

Coactivating and inhibitory receptors that share at least one ligand interact with a wide variety of ligands, indicating their importance in a range of situations. Here, we discuss principles of mainly human paired receptor function and ligand recognition, and possible therapeutic implications of targeting these receptors in cancer, autoimmune diseases, and allergy. We summarise and emphasise the idea that these receptors, which have evolved in part in response to pathogen pressure, fine-tune the immune response, preserve homeostasis, and that pathogens and tumours use the dominance of the inhibitory receptors over the coactivating receptors to avoid immune elimination. Finally, we discuss the options of using paired receptors and their ligand for immune cell education and therapy.

Recent experiments demonstrate substantial volatility of excitatory connectivity in the absence of any learning. This challenges the hypothesis that stable synaptic connections are necessary for long-term maintenance of acquired information. Here we measure ongoing synaptic volatility and use theoretical modeling to study its consequences on cortical dynamics. We show that in the balanced cortex, patterns of neural activity are primarily determined by inhibitory connectivity, despite the fact that most synapses and neurons are excitatory. Similarly, we show that the inhibitory network is more effective in storing memory patterns than the excitatory one. As a result, network activity is robust to ongoing volatility of excitatory synapses, as long as this volatility does not disrupt the balance between excitation and inhibition. We thus hypothesize that inhibitory connectivity, rather than excitatory, controls the maintenance and loss of information over long periods of time in the volatile cortex.

Bottom-up dissemination (BUD) of evidence based treatments (EBT), entailing the spread of an intervention through a peer network in a decentralized manner, is an under-reported phenomenon in the professional literature.

The trend of developing electrochemical sensors toward cellular level detection put forward higher requirements of the electrodes in the detection performance. However, common disk electrodes or conventional screen printing electrodes meet up with some limitations in the electrocatalytic activity and electron transfer capability. In this work, we applied inkjet printing technology to fabricate electrodes to make some improvements. Highly conductive Ag nanoparticles based electrodes were obtained on plastic substrate by inkjet printing technology followed by a sintering process at room temperature. The resistivity of IPAgE is determined to be 64.0 $\pm$ 5.3 μΩ cm. With better conductivity and the nanoparticle-based interface, superb electrochemical response of IPAgE for H2O2 was obtained, nearly 300-fold higher than the conventional screen printed Ag electrode. Moreover, high sensitivity of 287 μA mM−1 cm−2 with a LOD of 5.0 μM was obtained under the optimized 20 printed layers. The inkjet printed Ag electrodes were also credibly applied in the detection of H2O2 release from living cells. This work demonstrates inkjet printing is a promising method for the high performance electrochemical sensors.

Intestinal epithelial cells are multi-tasked cells that participate in digestion and absorption as well as in protection of the digestive tract. While information on the physiology and immune functions of intestinal epithelial cells in mammals is abundant, little is known of their immune function in birds and other species. Our main objectives were to study the development of anti-bacterial innate immune functions in the rapidly developing gut of the pre- and post-hatch chick and to determine the functional diversity of epithelial cells. After establishing primary intestinal epithelial cell cultures, we demonstrated their capacity to uptake and process bacteria. The response to bacterial products, LPS and LTA, induced expression of pro-inflammatory cytokine genes (IL-6, IL-18) as well as the expression of the acute phase proteins avidin, lysozyme and the secretory component derived from the polymeric immunoglobulin receptor. These proteins were then localized in gut sections, and the goblet cell was shown to store avidin, lysozyme as well as secretory component. Lysozyme staining was also located in a novel rod-shaped intestinal cell, situated at different loci along the villus, thus deviating from the classical Paneth cell in the mammal, that is restricted to crypts. Thus, in the chicken, the intestinal epithelium, and particularly goblet cells, are committed to innate immune protection. The unique role of the goblet cell in chicken intestinal immunity, as well as the unique distribution of lysozyme-positive cells highlight alternative solutions of gut protection in the bird.

Previous studies demonstrated that in-ovo photostimulation with monochromatic green light increased the somatotropic axis expression in broilers embryos. The objective of the current study was to detect the critical period for in-ovo GL photostimulation, in order to find the optimal targeted photostimulation period during the incubation process. Three hundred thirty-six fertile broiler eggs were divided into 4 groups. The first group was incubated under dark conditions as a negative control. The second incubated under intermittent monochromatic green light using light-emitting diode (LED) lamps with an intensity of 0.1 W\m2 at shell level from d 0 of the incubation as a positive control. The third group incubated under intermittent monochromatic green light from d 10 of the incubation. The last group incubated under intermittent monochromatic green light from d 15 of the incubation. In-ovo green light photostimulation from embryonic d 0 (ED0) increased plasma growth hormone (GH), as well as hypothalamic growth hormone releasing hormone (GHRH) and liver growth hormone receptor (GHR) and insulin-like growth factor-1 (IGF-1) mRNA levels. In-ovo green light photostimulation from ED10 increased the GH plasma levels compared to the negative control group, without affecting somatotropic axis mRNA genes expressions of GHRH, GHR, and IGF-1. In-ovo green light photostimulation from ED15 caused an increase in both the plasma GH levels and the somatotropic axis mRNA genes expressions of GHRH, GHR, and IGF-1, compared to the negative control group. These results suggest that the critical period of somatotropic axis acceleration by GL photostimulation start at 15 d of incubation.

ABSTRACT Previous studies demonstrated that in-ovo photostimulation with monochromatic green light increased the somatotropic axis expression in broilers embryos. The objective of the current study was to detect the critical period for in-ovo GL photostimulation, in order to find the optimal targeted photostimulation period during the incubation process. Three hundred thirty-six fertile broiler eggs were divided into 4 groups. The first group was incubated under dark conditions as a negative control. The second incubated under intermittent monochromatic green light using light-emitting diode (LED) lamps with an intensity of 0.1 W\m2 at shell level from d 0 of the incubation as a positive control. The third group incubated under intermittent monochromatic green light from d 10 of the incubation. The last group incubated under intermittent monochromatic green light from d 15 of the incubation. In-ovo green light photostimulation from embryonic d 0 (ED0) increased plasma growth hormone (GH), as well as hypothalamic growth hormone releasing hormone (GHRH) and liver growth hormone receptor (GHR) and insulin-like growth factor-1 (IGF-1) mRNA levels. In-ovo green light photostimulation from ED10 increased the GH plasma levels compared to the negative control group, without affecting somatotropic axis mRNA genes expressions of GHRH, GHR, and IGF-1. In-ovo green light photostimulation from ED15 caused an increase in both the plasma GH levels and the somatotropic axis mRNA genes expressions of GHRH, GHR, and IGF-1, compared to the negative control group. These results suggest that the critical period of somatotropic axis acceleration by GL photostimulation start at 15 d of incubation.

Spontaneous Raman scattering microspectroscopy, second harmonic generation (SHG) and 2-photon excited fluorescence (2PF) were used in combination to characterize the morphology together with the chemical composition of the cell wall in native plant tissues. As the data obtained with unstained sections of Sorghum bicolor root and leaf tissues illustrate, nonresonant as well as pre-resonant Raman microscopy in combination with hyperspectral analysis reveals details about the distribution and composition of the major cell wall constituents. Multivariate analysis of the Raman data allows separation of different tissue regions, specifically the endodermis, xylem and lumen. The orientation of cellulose microfibrils is obtained from polarization-resolved SHG signals. Furthermore, 2-photon autofluorescence images can be used to image lignification. The combined compositional, morphological and orientational information in the proposed coupling of SHG, Raman imaging and 2PF presents an extension of existing vibrational microspectroscopic imaging and multiphoton microscopic approaches not only for plant tissues.

Abstract The coordinated regulation between cellular glucose uptake and endogenous glucose production is indispensable for the maintenance of constant blood glucose concentrations. The liver contributes significantly to this process by altering the levels of hepatic glucose release, through controlling the processes of de novo glucose production (gluconeogenesis) and glycogen breakdown (glycogenolysis). Various nutritional and hormonal stimuli signal to alter hepatic gluconeogenic flux, and suppression of this metabolic pathway during the postprandial state can, to a significant extent, be attributed to insulin. Here, we review some of the molecular mechanisms through which insulin modulates hepatic gluconeogenesis, thus controlling glucose production by the liver to ultimately maintain normoglycemia. Various signaling pathways governed by insulin converge at the level of transcriptional regulation of the key hepatic gluconeogenic genes PCK1 and G6PC, highlighting this as one of the focal mechanisms through which gluconeogenesis is modulated. In individuals with compromised insulin signaling, such as insulin resistance in type 2 diabetes, insulin fails to suppress hepatic gluconeogenesis, even in the fed state; hence, an insight into these insulin-moderated pathways is critical for therapeutic purposes.

The coordinated regulation between cellular glucose uptake and endogenous glucose production is indispensable for the maintenance of constant blood glucose concentrations. The liver contributes significantly to this process by altering the levels of hepatic glucose release, through controlling the processes of de novo glucose production (gluconeogenesis) and glycogen breakdown (glycogenolysis). Various nutritional and hormonal stimuli signal to alter hepatic gluconeogenic flux, and suppression of this metabolic pathway during the postprandial state can, to a significant extent, be attributed to insulin. Here, we review some of the molecular mechanisms through which insulin modulates hepatic gluconeogenesis, thus controlling glucose production by the liver to ultimately maintain normoglycemia. Various signaling pathways governed by insulin converge at the level of transcriptional regulation of the key hepatic gluconeogenic genes PCK1 and G6PC, highlighting this as one of the focal mechanisms through which gluconeogenesis is modulated. In individuals with compromised insulin signaling, such as insulin resistance in type 2 diabetes, insulin fails to suppress hepatic gluconeogenesis, even in the fed state; hence, an insight into these insulin-moderated pathways is critical for therapeutic purposes.