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Paper won Best Student Paper Award from the International Transport Economics Association (ITEA 2022)

Ancient and medieval rhetorical theorists gave much attention to discovering an author’s intent (voluntas) from the letter of a document (scriptum). By contrast, resolving ambiguity (ambiguitas) was supposedly easy. But in fact, ambiguity proves the more slippery problem because it functions somewhere between argumentation (a controversy to be disputed) and stylistic embellishment. Legal discourse often tried to impose limits on ambiguity, but at the same time ambiguitas could be quietly weaponized — in both law and poetry — to transform legal and even theological meaning. Where rhetorical theorists such as Cicero, Quintilian, Augustine, William of Champeaux (c. 1100), Geoffrey of Vinsauf (c. 1210), and Boncompagno da Signa (c. 1235), as well as legal theorists such as Henry de Bracton, try to pin down how ambiguity works, poets such as William Langland seem to revel in the slippages that it affords.

 

January 2024: Rita Copeland is Sheli Z. and Burton X. Rosenberg Chair in the Humanities and Professor of Classics, English, and Comparative Literature at the University of Pennsylvnia.  Her publications include  Rhetoric, Hermeneutics, and Translation in the Middle Ages (Cambridge, 1991); Criticism and Dissent in the Middle Ages (Cambridge, 1996); Pedagogy, Intellectuals and Dissent in the Later Middle Ages (Cambridge 2001); Medieval Grammar and Rhetoric:  Language Arts and Literary Theory, AD 300-1475 (with I. Sluiter; Oxford, 2009); The Cambridge Companion to Allegory (with P. Struck; 2010), The Oxford History of Classical Reception in English Literature, 800-1558 (2016), and most recently, Emotion and the History of Rhetoric in the Middle Ages (Oxford, 2021).  She was a co-founder of the journal New Medieval Literatures.  She is General Editor (with the late Peter Mack) of the forthcoming Cambridge History of Rhetoric in five volumes.  She has been the recipient of NEH, ACLS, American Philosophical Society, and Guggenheim fellowships.  She is a Fellow of the Medieval Academy of America.  She has been a visiting professor at Hebrew University, University of Iceland, and University of Oxford, and a visiting fellow at the Warburg Institute, London.

‘Outdegree’ from directed graph theory is used to measure the salience of individual locations in the transmission of Covid-19 morbidity through the spatiotemporal network of contagion and their salience in the spatiotemporal diffusion of vaccination rollout. A spatial econometric model in which morbidity varies inversely with vaccination rollout, and vaccination rollout varies directly with morbidity is used to calculate dynamic auto-outdegrees for morbidity, and dynamic cross-outdegrees for the effect of vaccination on morbidity. The former identifies hot spots of contagion, and the latter identifies locations in which vaccination rollout is particularly effective in reducing national morbidity. These outdegrees are calculated analytically rather than simulated numerically.   

Book review

Soft grippers are garnering increasing attention for their adeptness in conforming to diverse objects, particularly delicate items, without warranting precise force control. This attribute proves especially beneficial in unstructured environments and dynamic tasks such as food handling. Human hands, owing to their elevated dexterity and precise motor control, exhibit the ability to delicately manipulate complex food items, such as small or fragile objects, by dynamically adjusting their grasping configurations. Furthermore, with their rich sensory receptors and hand-eye coordination that provide valuable information involving the texture and form factor, real-time adjustments to avoid damage or spill during food handling appear seamless. Despite numerous endeavors to replicate these capabilities through robotic solutions involving soft grippers, matching human performance remains a formidable engineering challenge. Robotic competitions serve as an invaluable platform for pushing the boundaries of manipulation capabilities, simultaneously offering insights into the adoption of these solutions across diverse domains, including food handling. Serving as a proxy for the future transition of robotic solutions from the laboratory to the market, these competitions simulate real-world challenges. Since 2021, our research group has actively participated in RoboSoft competitions, securing victories in the Manipulation track in 2022 and 2023. Our success was propelled by the utilization of a modified iteration of our Retractable Nails Soft Gripper (RNSG), tailored to meet the specific requirements of each task. The integration of sensors and collaborative manipulators further enhanced the gripper’s performance, facilitating the seamless execution of complex grasping tasks associated with food handling. This article encapsulates the experiential insights gained during the application of our highly versatile soft gripper in these competition environments.

The MAPK p38α was proposed to be a prominent promoter of skeletal muscle aging. The skeletal muscle tissue is composed of various muscle types, and it is not known if p38α is associated with aging in all of them. It is also not known if p38α is associated with aging of other tissues. JNK and ERK were also proposed to be associated with aging of several tissues. Nevertheless, the pattern of p38α, JNK, and ERK activity during aging was not documented. Here, we documented the levels of phosphorylated/active p38α, Erk1/2, and JNKs in several organs as well as the soleus, tibialis anterior, quadriceps, gastrocnemius, and EDL muscles of 1-, 3-, 6-, 13-, 18-, and 24-month-old mice. We report that in most tissues and skeletal muscles, the MAPKs' activity does not change in the course of aging. In most tissues and muscles, p38α is in fact active at younger ages. The quadriceps and the lungs are exceptions, where p38α is significantly active only in mice 13 months old or older. Curiously, levels of active JNK and ERKs are also elevated in aged lungs and quadriceps. RNA-seq analysis of the quadriceps during aging revealed downregulation of proteins related to the extra-cellular matrix (ECM) and ERK signaling. A panel of mRNAs encoding cell cycle inhibitors and senescence-associated proteins, considered to be aging markers, was not found to be elevated. It seems that the pattern of MAPKs' activation in aging, as well as expression of known 'aging' components, are tissue- and muscle type-specific, supporting a notion that the process of aging is tissue- and even cell-specific.

The edges of stone tools have significant technological and functional implications. The nature of these edges–their sharpness, whether they are concave or convex, and their asymmetry–reflect how they were made and how they could be used. Similarly, blunt portions of a tool’s perimeter hint at how they could have been grasped or hafted and in which directions force could be applied. However, due to the difficulty in accurately measuring the complex 3D geometry of tool edges with traditional methods, their attributes are often overlooked. When they are analyzed, they have traditionally been assessed with visual qualitative categories or unreliable physical measurements. We introduce new computational 3D methods for automatically and repeatably measuring key attributes of stone tool edges. These methods allow us to automatically identify the 3D perimeter of tools, segment this perimeter according to changes in edge angles, and measure these discrete edge segments with a range of metrics. We test this new computational toolkit on a large sample of 3D models of handaxes from the later Acheulean of the southern Levant. Despite these handaxes being otherwise technologically and morphologically similar, we find marked differences in the amount of knapped outline, edge angle, and the concavity of their edges. We find many handaxes possess blunt portions of perimeter, suitable for grasping, and some handaxes even possess more than one discrete sharp edge. Among our sample, sites with longer occupations and more diverse toolkits possessed handaxes with more diverse edges. Above all, this paper offers new methods for computing the complex 3D geometry of stone tool edges that could be applied to any number of artifact types. These methods are fully automated, allowing the analysis and visualization of entire assemblages. 

The present review deals with two main ingredients of energy/power drinks: B vitamins and glucuronolactone and their possible effect on the immune system. There is a strong relationship between the recommended daily dose of selected B vitamins and a functional immune system. Regarding specific B vitamins: (1) Riboflavin is necessary for the optimization of reactive oxygen species (ROS) in the fight against bacterial infections caused by Staphylococcus aureus and Listeria monocytogenes. (2) Niacin administered within normal doses to obese rats can change the phenotype of skeletal fibers, and thereby affect muscle metabolism. This metabolic phenotype induced by niacin treatment is also confirmed by stimulation of the expression of genes involved in the metabolism of free fatty acids (FFAs) and oxidative phosphorylation at this level. (3) Vitamin B5 effects depend primarily on the dose, thus large doses can cause diarrhea or functional disorders of the digestive tract whereas normal levels are effective in wound healing, liver detoxification, and joint health support. (4) High vitamin B6 concentrations (>2000 mg per day) have been shown to exert a significant negative impact on the dorsal root ganglia. Whereas, at doses of approximately 70 ng/mL, sensory symptoms were reported in 80% of cases. (5) Chronic increases in vitamin B12 have been associated with the increased incidence of solid cancers. Additionally, glucuronolactone, whose effects are not well known, represents a controversial compound. (6) Supplementing with D-glucarates, such as glucuronolactone, may help the body’s natural defense system function better to inhibit different tumor promoters and carcinogens and their consequences. Cumulatively, the present review aims to evaluate the relationship between the selected B vitamins group, glucuronolactone, and the immune system and their associations to bioavailability, doses, and efficiency.