Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk.

Citation:

MG Dunlop, Farrington, SM , Tenesa, A , Ooi, L-Y , Smillie, C , Grimes, G , Semple, C , Prendergast, J , Ballereau, S , Zgaga, L , Campbell, H , Dobbins, SE , Whiffin, N , Broderick, P , Henrion, M , Frampton, M , Ma, YP , Olver, B , Penegar, S , Lubbe, S , Lloyd, A , Vijayakrishnan, J , Houlston, RS , Jones, AM , Palles, C , Spain, S , Domingo, E , Martin, L , Gorman, M , Barclay, E , Cazier, J-B , Carvajal-Carmona, LG , Tomlinson, IP , Chander, I , Rudan, I , Theodoratou, E , Starr, JM , Deary, I , Kirac, I , Kovacevia, D , Aaltonen, LA , Renkonen-Sinisalo, L , Mecklin, J-P , Matsuda, K , Nakamura, Y , Okada, Y , Gallinger, S , Duggan, DJ , Conti, D , Schumacher, F , Casey, G , Newcomb, P , Hopper, J , Jenkins, MA , Easton, D , Shah, M , Pharoah, P , Edler, D , Janson, M , Lindblom, A , Liu, T , Smith, CG , West, H , Cheadle, JP , Midgley, R , and Kerr, DJ . 2012. “Common Variation Near Cdkn1A, Pold3 And Shroom2 Influences Colorectal Cancer Risk.”. http://search.ebscohost.com/login.aspx?direct=true&db=edsbas&AN=edsbas.ftucl.oai.eprints.ucl.ac.uk.OAI2.1405515&site=eds-live.

Abstract:

We performed a meta-analysis of five genome-wide association studies to identify common variants influencing colorectal cancer (CRC) risk comprising 8,682 cases and 9,649 controls. Replication analysis was performed in case-control sets totaling 21,096 cases and 19,555 controls. We identified three new CRC risk loci at 6p21 (rs1321311, near CDKN1A; P = 1.14 × 10 ), 11q13.4 (rs3824999, intronic to POLD3; P = 3.65 × 10 ) and Xp22.2 (rs5934683, near SHROOM2; P = 7.30 × 10 ) This brings the number of independent loci associated with CRC risk to 20 and provides further insight into the genetic architecture of inherited [...]