Classes

Protein Design and Evolution 92623

Semester: 

2nd semester

Offered: 

2020
A graduate course. This course surveys topics in two complementary approaches to protein engineering: computational protein design and directed protein evolution. Starting from the early works, it discusses the state-of-the-art methodology for computational design and for experimental directed evolution. It discusses how structural units could be designed and how protein function could be later introduced through protein engineering. Various breakthrough works are discussed to give the students the feel of the present research in the field of protein design and evolution.

Principles of Protein Folding 92987

Semester: 

2nd semester

Offered: 

2019
A course for the last year undergraduate and M. Sc. students. This course focuses on how an amino acid sequence of a protein determines its 3-Dimensional structure. The course introduces principles of protein structure, protein folding in the cell, and thermodynamic and kinetic methods for studying protein folding in vitro. Additional topics covered are roles of helper proteins such as chaperonins and isomerases, and diseases associated with protein folding defects. The most recent advances in the field are discussed.