פרסומים

Passported benefits are additional benefits provided to individual or households based on a previous eligibility to a "primary"social security benefit. Although passported benefits should be easier to claim, in reality the claiming process is often cumbersome and results in low take-up. Drawing on an Israeli case study, we offer a conceptual framework to categorize and analyse the varieties of passported benefits along five dimensions: the eligibility role of primary cash benefits; automation level; legal status; type of service delivery; and the degree of decentralization. The administrative burden literature is employed to make sense of the paradox of passported benefits becoming a site for administrative burden. Using our conceptual framework and drawing on interviews with officials and claimants, we demonstrate why some passported benefits are more user-friendly while others tend to become administratively burdensome.

Small round cell sarcoma is a group of undifferentiated malignancies arising in the bone and soft tissue, notable for Ewing sarcoma. Recently, a new World Health Organization classification has been introduced, including an additional subset of these sarcomas, named CIC-rearranged sarcoma. Within this group, CIC-FOXO4 translocation is an exceedingly rare fusion that has been reported only 4 times in the literature. Herein, we report in-depth the pathological, clinical, and molecular features of a CIC-FOXO4 translocation-driven tumor in a 46-year-old woman.

Fluorescent proteins (FP) are frequently used for studying proteins inside cells. In advanced fluorescence microscopy, FPs can report on additional intracellular variables. One variable is the local density near FPs, which can be useful in studying densities within cellular bio-condensates. Here, we show that a reduction in fluorescence lifetimes of common monomeric FPs reports increased levels of local densities. We demonstrate the use of this fluorescence-based variable to report the distribution of local densities within heterochromatin protein 1α (HP1α) in mouse embryonic stem cells (ESCs), before and after early differentiation. We find that local densities within HP1α condensates in pluripotent ESCs are heterogeneous and cannot be explained by a single liquid phase. Early differentiation, however, induces a change towards a more homogeneous distribution of local densities, which can be explained as a liquid-like phase. In conclusion, we provide a fluorescence-based method to report increased local densities and apply it to distinguish between homogeneous and heterogeneous local densities within bio-condensates.

Preprint - https://zenodo.org/records/7620845

Preregistration - https://osf.io/kucsw

Data & Code - https://osf.io/preprints/psyarxiv/yzcm7

Studies concerning nonlinear political dynamics, such as regime change, focus on macro-level structural factors and political agency. Tipping points are pitched mainly at these levels, and scholars therefore devote less attention to meso-level factors. To bridge this gap, this article develops a verbal model focusing on the collapse of mechanisms that sustain mythical state institutions as drivers of such dynamics. A mythical institution enjoys a reputation for power and influence among the public based on widespread and persistent stereotypical beliefs that embody a collectivity’s sense of origin and tradition, high performance and stability, and/or vision and mission. The argument advanced here is that nonlinear political dynamics may occur when the collapse of such mechanisms reflects on the unquestioned legitimacy that the mythical state institution enjoys, creating massive embarrassment for the regime because its mythical institution’s status requires government intervention to prevent believers from “fleeing” and/or revolting. This, in turn, undermines or debunks this institution’s myth, thereby generating high levels of anxiety, fear, anger, or other (mixes of) emotions. Which emotional process dominates depends on which reaction is stronger at the moment in question. When the level reaches an affective tipping point, citizens begin to update their evaluations and consider new information. This leads to behavioral convergence (e.g., mass protest, mass emigration, violence), which is in turn accelerated when the regime’s counter-response is publicly perceived as ineffective, thus highlighting the irreversibility of this process. This argument is illustrated herein by examining the 1989 collapse of East Germany’s emigration restrictions system.