The SysmedIBD Research Consortium:  http://www.sysmedibd.eu/home/                                                                  

Human gut xenograft in SCID mice:

Pathogenesis of enteropathogens in the human gut

Genome-wide comparative transcriptome analysis of steady state and inflamed human and mouse gut

Berlin 2016

A novel in vivo platform for the evaluation of new therapies for Crohn’s disease fistulae

Research aims:

1. Pharmacodynamics of anti TNF in normal and fistulating human gut xenografts.
2. Therapeutic effect of anti TNF on gut fistula in the model.
3. Therapeutic effect of allogeneic human MSCs on gut fistula in the model.