Citation:
Manuel Weber, Owens, Kyle , Masarwa*, Ahmad , and Sarpong*, Richmond . 2015. “Construction Of Enantiopure Taxoid And Natural Products-Like Scaffolds Using A C-C Bond Cleavage/Arylation Reaction”. Org. Lett., 17, Pp. 5432–5435. http://pubs.acs.org/doi/abs/10.1021/acs.orglett.5b02797.
Abstract:
An approach to construct enantiopure complex natural product-like frameworks, including the first reported synthesis of a C17 oxygenated taxoid scaffold, is presented. A palladium-catalyzed C–C activation/cross-coupling is utilized to access these structures in a short sequence from (+)-carvone; the scope of this reaction is explored.