Construction of Enantiopure Taxoid and Natural Products-Like Scaffolds Using a C-C Bond Cleavage/Arylation Reaction

Abstract:

An approach to construct enantiopure complex natural product-like frameworks, including the first reported synthesis of a C17 oxygenated taxoid scaffold, is presented. A palladium-catalyzed C–C activation/cross-coupling is utilized to access these structures in a short sequence from (+)-carvone; the scope of this reaction is explored.