Citation:
Meshorer, E., & Gruenbaum, Y. . (2008). Gone with the Wnt/Notch: stem cells in laminopathies, progeria, and aging. J Cell Biol, 181(1), 9-13. presented at the 2008 Apr 7. doi:10.1083/jcb.200802155
Date Published:
2008 Apr 7Abstract:
Specific mutations in the human gene encoding lamin A or in the lamin A-processing enzyme, Zmpste24, cause premature aging. New data on mice and humans suggest that these mutations affect adult stem cells by interfering with the Notch and Wnt signaling pathways.