Abstract:

An established experimental model of tibial bone regeneration in rats was used in order to try to provide further information on the binding site of 99mTc-MDP, which is still not clearly defined. Four groups of rats on which surgical tibial bone marrow evacuation was performed and two control groups (nonoperated animals and sham-operated animals) underwent bone scan during the different stages of marrow regeneration; they were killed immediately after, and histological examination carried out. The correlation between the scintigraphic and the histological findings suggests that 99mTc-MDP binds primarily to calcification sites in young bone trabecules.

Notes:

Chisin, R Gazit, D Ulmansky, M Laron, A Atlan, H Sela, J eng England 1988/01/01 Int J Rad Appl Instrum B. 1988;15(4):469-76.