The addition of avibactam renders piperacillin an effective treatment for Mycobacterium abscessus infection in an in vivo model

Citation:

Michal Meir, Bifani, Pablo , and Barkan, Daniel . 2018. “The Addition Of Avibactam Renders Piperacillin An Effective Treatment For Mycobacterium Abscessus Infection In An In Vivo Model”. Antimicrobial Resistance And Infection Control, 7. doi:10.1186/s13756-018-0448-4.

Abstract:

Treating M. abscessus infection is challenging due to the potent β-lactamase Bla Mab (Beta-lactamase of M. abscessus ) . Avibactam is a non-β-lactam, β-lactamase inhibitor shown to inhibit Bla Mab . We tested whether avibactem can render piperacillin effective against M. Abscessus. In-vitro, avibactam enhanced the activity of piperacillin by 16-32 fold, with no significant effect on meropenem. In an in-vivo Galleria mellonella model, meropenem and piperacillin/avibactam significantly decreased infection burden compared to untreated controls. Neither piperacillin nor avibactam alone had a significant effect.

Notes:

Publisher Copyright: © 2018 The Author(s).