A structured graduated protocol with heat denatured eggs in the treatment of egg allergy

Citation:

L Gotesdyner, Zeldin, Y, Machnes Maayan, D, Efron, A, Stauber, T, Maoz Segal, R, Binson, I, Dinkin, M, Dinkowitz, L, Nevet, A, Asher, I, Yakar, Y, Agmon-Levin, N, Kenett, RS, ו Kidon, MI. 2019. “A Structured Graduated Protocol With Heat Denatured Eggs In The Treatment Of Egg Allergy”. Pediatr Allergy Immunol, 30, 8, Pp. 824–832.

תקציר:

{Most children with egg allergy (EA) can tolerate extensively heated and baked egg (EHBE). Consumption of EHBE may promote faster resolution of EA; however, no consensus exists as to the required amounts and treatment protocols.\\ To evaluate the efficacy and safety of a structured graduated exposure protocol (SGEP) with EHBE in promoting tolerance to eggs in EA children under 2 years of age.\\ 2 years who were treated with SGEP including EHBE were compared to children treated with strict avoidance. Data were collected from records and telephone questionnaires. Analysis was performed using non-parametric Kaplan-Meier and Cox proportional hazard regression models.\\ .001. At last follow-up, 82% of treated children were tolerant to lightly cooked eggs vs 54% of controls