Citation:
Moran Haim-Zada, Basu, Arijit , Hagigit, Tal , Schlinger, Ron , Grishko, Michael , Kraminsky, Alexander , Hanuka, Ezra , ו Domb, Abraham J. 2017. “Stable Polyanhydride Synthesized From Sebacic Acid And Ricinoleic Acid.”. Journal Of Controlled Release : Official Journal Of The Controlled Release Society, 257, Pp. 156–162. doi:10.1016/j.jconrel.2016.04.036.
תקציר:
Poly(anhydride) are unstable and prone to hydrolytic degradation and depolymerisation via anhydride interchange. They are stored at -20°C, packed under inert atmosphere until use. We synthesized a new poly(anhydride) from ricinoleic (RA) and sebacic (SA) acid with alternating ester-anhydride structure that is stable at 25°C for over 18months. The copolymer is also stable in chloroform solution and under $\gamma$-irradiation. The polymer hydrolyses through anhydride cleavage lasting $\sim$7days to form oligoesters, which are stable for >30days. The release of gentamycin from the synthesized alternate polymer matrix is sustained compared to the random copolymer.