Semiautomated synthesis of a novel [18F] amine fluorocyanoborane for PET imaging studies. Radiosynthesis and in vivo characterization in rats.

Citation:

Eli Shalom, Takrouri, Khuloud , Metsuyanim, Nir , Grufi, Arik , Katzhendler, Jehoshua , ו Srebnik, Morris . 2007. “Semiautomated Synthesis Of A Novel [18F] Amine Fluorocyanoborane For Pet Imaging Studies. Radiosynthesis And In Vivo Characterization In Rats.”. Applied Radiation And Isotopes : Including Data, Instrumentation And Methods For Use In Agriculture, Industry And Medicine, 65, 2, Pp. 204–208. doi:10.1016/j.apradiso.2006.08.014.

תקציר:

A novel fluorine-18 labeled amine fluorocyanoborane derivative was synthesized from the bromo-derivative precursor in 22% radiochemical yield. The [18F] labeling was accomplished by a semiautomatic method that is based on the synthesis of Ag 18F from Ag2CO3 and H 18F in a platinum dish followed by sonication of the bromo-precursor with Ag 18F in dry benzene to produce [18F] labeled amine fluorocyanoborane which was used with no further purification. A total of 50 microCi of the [18F] labeled amine fluorocyanoborane was injected into normal, female Sprague-Dawley rats (250-300 g) via the tail vein and monitored by Positron emission tomography (PET)/CT to detect its biodistribution in the rat body. The images showed an uptake of this compound in the bones of rats.