Citation:
F Yan, Liao, R, Silva, M, Li, S, Jiang, Y, Peng, T, Lazarovici, P, ו Zheng, W. 2020. “Pristimerin-Induced Uveal Melanoma Cell Death Via Inhibiting Pi3K/Akt/Foxo3A Signalling Pathway”. J Cell Mol Med, 24, 11, Pp. 6208–6219.
תקציר:
, cleaved caspase-3, PARP and Bax, and decreased the expression of Cyclin D1 and Bcl-2. LY294002 or Akt-siRNA inhibited the PI3K/Akt/FoxO3a pathway and promoted the Pristimerin-induced apoptosis, while Pristimerin effects were partially abolished in FoxO3a knockdown UM-1 cell cultures. Taken together, present results showed that Pristimerin induced apoptotic cell death through inhibition of PI3K/Akt/FoxO3a pathway in UM-1 cells. These findings indicate that Pristimerin may be considered as a potential chemotherapeutic agent for patients with UM.