Citation:
Abed Al Aziz Al Quntar, Gallily, Ruth , Katzavian, Galia , ו Srebnik, Morris . 2007. “Potent Anti-Inflammatory Activity Of 3-Aminovinylphosphonates As Inhibitors Of Reactive Oxygen Intermediates, Nitric Oxides Generation, And Tumor Necrosis Factor-Alpha Release.”. European Journal Of Pharmacology, 556, 1-3, Pp. 9–13. doi:10.1016/j.ejphar.2006.10.041.
תקציר:
Two 3-aminoalkenylphosphonate compounds 1, 2, and a hydroxyl derivative, 2-(3-hydroxy-3-phenylpropyl)hex-1-enylphosphonate 3, recently synthesized in our lab, have been evaluated for their ability to modulate the production of reactive oxygen intermediates, nitric oxide (NO) and tumor necrosis factor (TNF-alpha) by murine macrophages. We found that all three molecules suppressed generation of reactive oxygen intermediates, NO, and TNF-alpha. However, although 2-(3-hydroxy-3-phenylpropyl)hex-1-enylphosphonate 3 possessed higher activity in suppression of reactive oxygen intermediates and nitric oxide compared to 3-aminoalkenylphosphonates 1 and 2, it showed less activity in the inhibition of tumor necrosis factor release.