Spermine induces haemoglobin synthesis in murine erythroleukaemia cells

Citation:

J. G. Delcros, Schwartz, B. , Clement, S. , Basu, H. S. , Marton, L. J. , and Feuerstein, B. G. . 1995. “Spermine Induces Haemoglobin Synthesis In Murine Erythroleukaemia Cells”. Biochem J, 309 ( Pt 3), Pp. 781-6. doi:10.1042/bj3090781.

Abstract:

The naturally occurring polyamine spermine induces haemoglobin synthesis in murine erythroleukaemia (MEL) cells. Haemoglobin production was accompanied by accumulation of cytoplasmic beta-globin mRNA and growth inhibition, but not by cell-cycle block or changes in cell volume. Hexamethylene-bisacetamide (HMBA), a well known differentiating agent, also induces haemoglobin production, but causes a G1 block and decreases cell volume. These findings indicate that HMBA and spermine affect MEL cells differently, even though both induce haemoglobin production.

Notes:

Delcros, J G Schwartz, B Clement, S Basu, H S Marton, L J Feuerstein, B G eng CA13525/CA/NCI NIH HHS/ CA41757/CA/NCI NIH HHS/ CA49409/CA/NCI NIH HHS/ Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. England 1995/08/01 00:00 Biochem J. 1995 Aug 1;309 ( Pt 3):781-6. doi: 10.1042/bj3090781.