Publications

2021
A. Helman and Melton, D. A. . 2021. “A Stem Cell Approach To Cure Type 1 Diabetes”. Cold Spring Harb Perspect Biol, 13, 1.
2020
J. R. Alvarez-Dominguez, Donaghey, J. , Rasouli, N. , Kenty, J. H. R. , Helman, A. , Charlton, J. , Straubhaar, J. R. , Meissner, A. , and Melton, D. A. . 2020. “Circadian Entrainment Triggers Maturation Of Human In Vitro Islets”. Cell Stem Cell, 26, 1, Pp. 108–122.
J. C. Davis, Alves, T. C. , Helman, A. , Chen, J. C. , Kenty, J. H. , Cardone, R. L. , Liu, D. R. , Kibbey, R. G. , and Melton, D. A. . 2020. “Glucose Response By Stem Cell-Derived Β Cells In Vitro Is Inhibited By A Bottleneck In Glycolysis”. Cell Rep, 31, 6, Pp. 107623.
J. C. Garbern, Helman, A. , Sereda, R. , Sarikhani, M. , Ahmed, A. , Escalante, G. O. , Ogurlu, R. , Kim, S. L. , Zimmerman, J. F. , Cho, A. , MacQueen, L. , Bezzerides, V. J. , Parker, K. K. , Melton, D. A. , and Lee, R. T. . 2020. “Inhibition Of Mtor Signaling Enhances Maturation Of Cardiomyocytes Derived From Human-Induced Pluripotent Stem Cells Via P53-Induced Quiescence”. Circulation, 141, 4, Pp. 285–300.
A. Helman, Cangelosi, A. L. , Davis, J. C. , Pham, Q. , Rothman, A. , Faust, A. L. , Straubhaar, J. R. , Sabatini, D.M. , and Melton, D. A. . 2020. “A Nutrient-Sensing Transition At Birth Triggers Glucose-Responsive Insulin Secretion”. Cell Metab, 31, 5, Pp. 1004–1016.
2019
J. C. Davis, Helman, A. , Rivera-Feliciano, J. , Langston, C. M. , Engquist, E. N. , and Melton, D. A. . 2019. “Live Cell Monitoring And Enrichment Of Stem Cell-Derived Β Cells Using Intracellular Zinc Content As A Population Marker”. Curr Protoc Stem Cell Biol, 51, 1, Pp. e99.
2018
S. Anzi, Stolovich-Rain, M. , Klochendler, A. , Fridlich, O. , Helman, A. , Paz-Sonnenfeld, A. , Avni-Magen, N. , Kaufman, E. , Ginzberg, M. B. , Snider, D. , Ray, S. , Brecht, M. , Holmes, M. M. , Meir, K. , Avivi, A. , Shams, I. , Berkowitz, A. , Shapiro, A. M. J. , Glaser, B. , Ben-Sasson, S. , Kafri, R. , and Dor, Y. . 2018. “Postnatal Exocrine Pancreas Growth By Cellular Hypertrophy Correlates With A Shorter Lifespan In Mammals”. Dev Cell, 45, 6, Pp. 726–737.
2017
T. Kushnir, Mezuman, S. , Bar-Cohen, S. , Lange, R. , Paroush, Z. , and Helman, A. . 2017. “Novel Interplay Between Jnk And Egfr Signaling In Drosophila Dorsal Closure”. Plos Genet, 13, 6, Pp. e1006860.
2016
A. Klochendler, Caspi, I. , Corem, N. , Moran, M. , Friedlich, O. , Elgavish, S. , Nevo, Y. , Helman, A. , Glaser, B. , Eden, A. , Itzkovitz, S. , and Dor, Y. . 2016. “The Genetic Program Of Pancreatic Β-Cell Replication In Vivo”. Diabetes, 65, 7, Pp. 2081–2093.
A. Helman, Klochendler, A. , Azazmeh, N. , Gabai, Y. , Horwitz, E. , Anzi, S. , Swisa, A. , Condiotti, R. , Granit, R. Z. , Nevo, Y. , Fixler, Y. , Shreibman, D. , Zamir, A. , Tornovsky-Babeay, S. , Dai, C. , Glaser, B. , Powers, A. C. , Shapiro, A. M. , Magnuson, M. A. , Dor, Y. , and Ben-Porath, I. . 2016. “P16(Ink4A)-Induced Senescence Of Pancreatic Beta Cells Enhances Insulin Secretion”. Nat Med, 22, 4, Pp. 412–420.
2013
R. Tokarsky-Amiel, Azazmeh, N. , Helman, A. , Stein, Y. , Hassan, A. , Maly, A. , and Ben-Porath, I. . 2013. “Dynamics Of Senescent Cell Formation And Retention Revealed By P14Arf Induction In The Epidermis”. Cancer Res, 73, 9, Pp. 2829–2839.
2012
A. Helman, Lim, B. , Andreu, M. J. , Kim, Y. , Shestkin, T. , Lu, H. , Jiménez, G. , Shvartsman, S. Y. , and Paroush, Z.. 2012. “Rtk Signaling Modulates The Dorsal Gradient”. Development, 139, 16, Pp. 3032–3039.
2011
L. Ajuria, Nieva, C. , Winkler, C. , Kuo, D. , Samper, N. , Andreu, M. J. , Helman, A. , González-Crespo, S. , Paroush, Z. , Courey, A. J. , and Jiménez, G. . 2011. “Capicua Dna-Binding Sites Are General Response Elements For Rtk Signaling In Drosophila”. Development, 138, 5, Pp. 915–924.
A. Helman, Cinnamon, E. , Mezuman, S. , Hayouka, Z. , Von Ohlen, T. , Orian, A. , Jiménez, G. , and Paroush, Z.. 2011. “Phosphorylation Of Groucho Mediates Rtk Feedback Inhibition And Prolonged Pathway Target Gene Expression”. Curr Biol, 21, 13, Pp. 1102–1110.
C. Moses, Helman, A. , Paroush, Z. , and Von Ohlen, T. . 2011. “Phosphorylation Of Ind By Map Kinase Enhances Ind-Dependent Transcriptional Repression”. Dev Biol, 360, 1, Pp. 208–215.
2010
A. Helman and Paroush, Z. . 2010. “Detection Of Rtk Pathway Activation In Drosophila Using Anti-Dperk Immunofluorescence Staining”. Methods Mol Biol, 661, Pp. 401–408.
2008
E. Cinnamon, Helman, A. , Ben-Haroush Schyr, R. , Orian, A. , Jiménez, G. , and Paroush, Z.. 2008. “Multiple Rtk Pathways Downregulate Groucho-Mediated Repression In Drosophila Embryogenesis”. Development, 135, 5, Pp. 829–837.
2005
A. Revel, Helman, A. , Koler, M. , Shushan, A. , Goldshmidt, O. , Zcharia, E. , Aingorn, H. , and Vlodavsky, I. . 2005. “Heparanase Improves Mouse Embryo Implantation”. Fertil Steril, 83, 3, Pp. 580–586.
2004
E. Cinnamon, Gur-Wahnon, D. , Helman, A. , St Johnston, D. , Jiménez, G. , and Paroush, Z.. 2004. “Capicua Integrates Input From Two Maternal Systems In Drosophila Terminal Patterning”. Embo J, 23, 23, Pp. 4571–4582.
A. Revel, Moshe, N. , Helman, A. , Safran, A. , Simon, A. , and Koler, M. . 2004. “Mouse Embryos Generated From Frozen-Thawed Oocytes Can Successfully Survive A Second Cryopreservation”. Hum Reprod, 19, 3, Pp. 666–669.