פרסומים

2015
Yiftah Elazar. 2015. Liberty As A Caricature: Bentham&Rsquo;S Antidote To Republicanism.. Journal Of The History Of Ideas, 76, 3, Pp. 417-439. . Publisher's Version תקציר
This article reconsiders Bentham’s theory of liberty in relation to republican and democratic ideas in the Age of Revolution. It reinterprets his jurisprudential definitions of liberty as ideological weapons intended to “cut the throat” of pro-American and proto-democratic discourse. In particular, his negative definition of individual liberty and his democratic and international definitions of political liberty were designed and used to caricature and draw to absurdity the republican ideal of self-government. The early Bentham, according to this interpretation, was a subversive critic of republicanism, who occupied its language of liberty and security while trying to neutralize its democratic potential.
Galit Almoznino, Aframian, D.J. , Sharav, Y. , Sheftel, Y. , Mirzabaev, A. , ו Zini, A.. 2015. Lifestyle And Dental Attendance As Predictors Of Oral Health-Related Quality Of Life. Oral Diseases, 21, Pp. 659 – 666. doi:10.1111/odi.12331. Publisher's Version
Nir Kedem, Brenner, Thomas M, Kulbak, Michael , Schaefer, Norbert , Levcenko, Sergiu , Levine, Igal , Abou-Ras, Daniel , Hodes, Gary , ו Cahen, David . 2015. Light-Induced Increase Of Electron Diffusion Length In Ap–N Junction Type Ch3Nh3Pbbr3 Perovskite Solar Cell. The Journal Of Physical Chemistry Letters, 6, Pp. 2469–2476.
Hagai Arbell ו Banin, Uri . 2015. Lighting Devices With Prescribed Colour Emission. United States of America.
JE Avron, Kenneth, O, Retzker, A, ו Shalyt, M. 4/8/2015. Lindbladians For Controlled Stochastic Hamiltonians. New Journal Of Physics, 17. . Publisher's Version
We construct Lindbladians associated with controlled stochastic Hamiltonians in the weak coupling regime. This construction allows us to determine the power spectrum of the noise from measurements of dephasing rates. Moreover, by studying the derived equation it is possible to optimize the control as well as to test numerical algorithms that solve controlled stochastic Schrödinger equations. A few examples are worked out in detail.
Oded Sandler, Mizrahi, Sivan Pearl, Weiss, Noga , Agam, Oded , Simon, Itamar , ו Balaban, Nathalie Q. 2015. Lineage Correlations Of Single Cell Division Time As A Probe Of Cell-Cycle Dynamics. Nature, 519, Pp. 468–471. . Publisher's Version
Tomer Shpilka, Welter, Evelyn , Borovsky, Noam , Amar, Nira , Mari, Muriel , Reggiori, Fulvio , ו Elazar, Zvulun . 2015. Lipid Droplets And Their Component Triglycerides And Steryl Esters Regulate Autophagosome Biogenesis. The Embo Journal, 34, Pp. 2117–2131.
Tomer Shpilka ו Elazar, Zvulun . 2015. Lipid Droplets Regulate Autophagosome Biogenesis. Autophagy, 11, Pp. 2130–2131.
Daniel Sharon, Hirshberg, Daniel , Afri, Michal , Garsuch, Arnd , Frimer, Aryeh A. , ו Aurbach, Doron . 2015. Lithium-Oxygen Electrochemistry In Non-Aqueous Solutions. Israel Journal Of Chemistry, 55, 5, Pp. 508–520. doi:10.1002/ijch.201400135. Publisher's Version
Dan Ofer, Rappoport, Nadav , ו Linial, Michal . 2015. The Little Known Universe Of Short Proteins In Insects: A Machine Learning Approach. בתוך Short Views On Insect Genomics And Proteomics, Pp. 177–202. Springer.
Michal Herzenstein, Horsky, Sharon , ו Posavac, Steven S.. 2015. Living With Terrorism Or Withdrawing In Terror: Perceived Control And Consumer Avoidance. Journal Of Consumer Behaviour, 14, 4 July/August, Pp. 228-236. . Publisher's Version
Local Democracy in Israel: Decentralization, Localism, Participation and Local Politics

The democratic function of local authorities is often disregarded in the public discourse on local government and needed municipal reforms. This deficiency characterizes countries, including Israel, in which local government is not perceived as a cornerstone of national identity. Local democracy has three major functions: representation, consolidation of democratic values and pluralism. This book focuses on the democratic objective of local government in Israel. Its twenty-two chapters review key trends in local democracy and discuss its position in the public and political systems, in civil participation, management of civic life at the local level and local government elections. Four features of local democracy in Israel revealed in the chapters of the book are: distinction, centralization along with neglect, fragility and exploitation, and suspicion and protest. The challenges facing local democracy in Israel are manifested in several courses of action: from below – awakening of the local civil society; from within – adoption of new public management principles by elected politicians and bureaucrats in local government; from above – genuine decentralization of powers by the central state; and from outside – direct interaction with states and international movements, organizations and corporations.

Beeri and Razin_Local Democracy in Israel_part a.pdf Beeri and Razin_Local Democracy in Israel_part b.pdf
G. Levy, Bomze, D. , Heinz, S. , Ramachandran, S.D. , Noerenberg, A. , Cohen, M. , Shibolet, O. , Sklan, E. , Braspenning, J. , ו Nahmias, Y.. 2015. Long-Term Culture And Expansion Of Primary Human Hepatocytes. Nature Biotechnology, 33, Pp. 1264-1271. doi:10.1038/nbt.3377. Publisher's Version תקציר
Hepatocytes have a critical role in metabolism, but their study is limited by the inability to expand primary hepatocytes in vitro while maintaining proliferative capacity and metabolic function. Here we describe the oncostatin M (OSM)-dependent expansion of primary human hepatocytes by low expression of the human papilloma virus (HPV) genes E6 and E7 coupled with inhibition of epithelial-to-mesenchymal transition. We show that E6 and E7 expression upregulates the OSM receptor gp130 and that OSM stimulation induces hepatocytes to expand for up to 40 population doublings, producing 1013 to 1016 cells from a single human hepatocyte isolate. OSM removal induces differentiation into metabolically functional, polarized hepatocytes with functional bile canaliculi. Differentiated hepatocytes show transcriptional and toxicity profiles and cytochrome P450 induction similar to those of primary human hepatocytes. Replication and infectivity of hepatitis C virus (HCV) in differentiated hepatocytes are similar to those of Huh7.5.1 human hepatoma cells. These results offer a means of expanding human hepatocytes of different genetic backgrounds for research, clinical applications and pharmaceutical development. © 2015 Nature America, Inc.
Yuval Ramot, Nyska, Abraham , Markovitz, Elana , Dekel, Assaf , Klaiman, Guy , Zada, Moran Haim , Domb, Abraham J, ו Maronpot, Robert R. 2015. Long-Term Local And Systemic Safety Of Poly (L-Lactide-Co-Epsilon-Caprolactone) After Subcutaneous And Intra-Articular Implantation In Rats. Toxicologic Pathology, 43, 8, Pp. 1127–1140.
Yuval Ramot, Nyska, Abraham , Markovitz, Elana , Dekel, Assaf , Klaiman, Guy , Zada, Moran Haim , Domb, Abraham J, ו Maronpot, Robert R. 2015. Long-Term Local And Systemic Safety Of Poly(L-Lactide-Co-Epsilon-Caprolactone) After Subcutaneous And Intra-Articular Implantation In Rats.. Toxicologic Pathology, 43, 8, Pp. 1127–1140. doi:10.1177/0192623315600275. תקציר
The use of biodegradable materials is gaining popularity in medicine, especially in orthopedic applications. However, preclinical evaluation of biodegradable materials can be challenging, since they are located in close contact with host tissues and might be implanted for a long period of time. Evaluation of these compounds requires biodegradability and biocompatibility studies and meticulous pathology examination. We describe 2 preclinical studies performed on Sprague-Dawley rats for 52 weeks, to evaluate clinical pathology, biocompatibility, biodegradability, and systemic toxicity after implantation of 2-layered films or saline-inflated balloon-shaped implants of downsized InSpace™ devices (termed "test device"). The test devices are made from a copolymer of poly-L-lactide-co-∊-caprolactone in a 70:30 ratio, identical to the device used in humans, intended for the treatment of rotator cuff tears. Intra-articular film implantation and subcutaneous implantation of the downsized device showed favorable local and systemic tolerability. Although the implanted materials have no inherent toxic or tumorigenic properties, one animal developed a fibrosarcoma at the implantation site, an event that is associated with a rodent-predilection response where solid materials cause mesenchymal neoplasms. This effect is discussed in the context of biodegradable materials along with a detailed description of expected pathology for biodegradable materials in long-term rodent studies.
Loss of osteoblast Runx3 produces severe congenital osteopenia
O. Bauer, Sharir, A. , Kimura, A. , Hantisteanu, S. , Takeda, S. , ו Groner, Y.. 2015. Loss Of Osteoblast Runx3 Produces Severe Congenital Osteopenia. Molecular And Cellular Biology, 35, 7, Pp. 1097-1109.
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