2015
The start of the twentieth century ushered in a period of unprecedented change in the Middle East. These transformations, brought about by the emergence of the modern state system and an increasing interaction with a more globalized economy, irrevocably altered the political and social structures of the Middle East, even as the region itself left its mark on the processes of globalization themselves. As a result of these changes, there was an intensification in the movement of people, commodities and ideas across the globe: commercial activity, urban space, intellectual life, leisure culture, immigration patterns and education - nothing was left untouched. It shows how even as the Middle East was responding to increased economic interactions with the rest of the world by restructuring not only local economies, but also cultural, political and social institutions, the region's engagement with these trends altered the nature of globalization itself. This period has been seen as one in which the modern state system and its oftentimes artificial boundaries emerged in the Middle East. But this book highlights how, despite this, it was also one of tremendous interconnection.
Approaching the first period of modern globalization by investigating the movement of people, objects and ideas into, around and out of the Middle East, the authors demonstrate how the Middle East in this period was not simply subject or reactive to the West, but rather an active participant in the transnational flows that transformed both the region and the world. A Global Middle East offers an examination of a variety of intellectual and more material exchanges, such as nascent feminist movements and Islamist ideologies as well as the movement of sex workers across the Mediterranean and Jewish migration into Palestine. A Global Middle East emphasises this by examining the multi-directional nature of movement across borders, as well as this movement's intensity, volume and speed. By focusing on the theme of mobility as the defining feature of 'modern globalization' in the Middle East, it provides an essential examination of the formative years of the region.
Belief in God's control of the world is common to many of the world's religions, but there are conflicting predictions regarding its role in shaping attitudes toward the welfare state. While the devout are expected to support pro-social values like helping others, and thus might be supportive of the welfare state, the possibility of taking action is undermined by the belief in God's absolute control over world affairs and in a morally perfect providence, who is responsible for the fates of individuals. As the literature provides mixed results on this question, this study examines the role of belief in God's control on welfare attitudes using three priming experiments and two priming tasks, carried out with a design that is both cross-cultural (US vs. Israel) and cross-religious tradition (Judaism vs. Catholicism). We find evidence that, largely, belief in God's control increases support for income redistribution among Israeli Jews (study 1), American Jews (study 2), and American Catholics (study 3). The findings suggest that the traditional and common political gap between the economic left and the religious, based on the evaluation that religious beliefs lead to conservative economic preferences, may be overstated.
T. Golan, Messer, A. R. , Amitai-Lange, A. , Melamed, Z. , Ohana, R. , Bell, R. E. , Kapitansky, O. , Lerman, G. , Greenberger, S. , Khaled, M. , Amar, N. , Albrengues, J. , Gaggioli, C. , Gonen, P. , Tabach, Y. , Sprinzak, D. , Shalom-Feuerstein, R. , ו Levy, C.. 2015.
“Interactions Of Melanoma Cells With Distal Keratinocytes Trigger Metastasis Via Notch Signaling Inhibition Of Mitf”. Mol Cell, 59, Pp. 664-76.
The most critical stage in initiation of melanoma metastasis is the radial to vertical growth transition, yet the triggers of this transition remain elusive. We suggest that the microenvironment drives melanoma metastasis independently of mutation acquisition. Here we examined the changes in microenvironment that occur during melanoma radial growth. We show that direct contact of melanoma cells with the remote epidermal layer triggers vertical invasion via Notch signaling activation, the latter serving to inhibit MITF function. Briefly, within the native Notch ligand-free microenvironment, MITF, the melanocyte lineage master regulator, binds and represses miR-222/221 promoter in an RBPJK-dependent manner. However, when radial growth brings melanoma cells into contact with distal differentiated keratinocytes that express Notch ligands, the activated Notch intracellular domain impairs MITF binding to miR-222/221 promoter. This de-repression of miR-222/221 expression triggers initiation of invasion. Our findings may direct melanoma prevention opportunities via targeting specific microenvironments.
Why is the world orderly, and how does this order come to be? Human beings inhabit a multitude of apparently ordered systems—natural, social, political, economic, cognitive, and others—whose origins and purposes are often obscure. In the eighteenth century, older certainties about such orders, rooted in either divine providence or the mechanical operations of nature, began to fall away. In their place arose a new appreciation for the complexity of things, a new recognition of the world’s disorder and randomness, new doubts about simple relations of cause and effect—but with them also a new ability to imagine the world’s orders, whether natural or manmade, as self-organizing. If large systems are left to their own devices, eighteenth-century Europeans increasingly came to believe, order will emerge on its own without any need for external design or direction.
In Invisible Hands, Jonathan Sheehan and Dror Wahrman trace the many appearances of the language of self-organization in the eighteenth-century West. Across an array of domains, including religion, society, philosophy, science, politics, economy, and law, they show how and why this way of thinking came into the public view, then grew in prominence and arrived at the threshold of the nineteenth century in versatile, multifarious, and often surprising forms. Offering a new synthesis of intellectual and cultural developments, Invisible Hands is a landmark contribution to the history of the Enlightenment and eighteenth-century culture.
Amblyopia is a deficit in vision that arises from abnormal visual experience early in life. It was long thought to develop into a permanent deficit, unless properly treated before the end of the sensitive period for visual recovery. However, a number of studies now suggest that adults with long-standing amblyopia may at least partially recover visual acuity and stereopsis following perceptual training. Eliminating or reducing interocular suppression has been hypothesized to be at the root of these changes. Here we show that playing a novel dichoptic video game indeed results in reduced suppression, improved visual acuity and, in some cases, improved stereopsis. Our relatively large cohort of adults with amblyopia, allowed us, for the first time, to assess the link between visual function recovery and reduction in suppression. Surprisingly, no significant correlation was found between decreased suppression and improved visual function. This finding challenges the prevailing view and su
Before participating in the teachers’ workshop, I used to address HOT in my teaching intuitively. But now I realize that doing so without explicitly addressing metacognition means that I had accomplished only a very small part of the job. (a participant in a teachers’ professional development workshop) Since the early days of studying metacognition, metacognitive training and instruction were shown to have positive effects on children’s performance in diverse fields. As we shall see in what follows, metacognition has both domain-general and domain-specific features. Therefore, it makes sense to study metacognition in general contexts as well as in the context of specific school disciplines and even in the context of more specific learning goals. Accordingly, the goal of this chapter is to present an overview of the role of metacognition in teaching higher order thinking (HOT) in science classrooms.
In the course of our studies on structured reverse lyotropic liquid crystals (LLC) as oleogels, a system was designed with the desired physical and rheology properties for cosmetic and pharmaceutical applications. The aqueous phase was partially replaced by glycerol to minimize bacteriological problems and obtain specific rheology characteristics. The constructed phase diagrams are based on ternary mixtures of glycerol monooleate (GMO), decane, water, and glycerol. The main lyotropic mesophase obtained in this study was reverse hexagonal derived from dilution line 8:2 (72 wt% GMO and 18 wt% decane) and 10 wt% water; or water:glycerol (wt ratios 3:1 and 1:1) mixture. It was found that heat-cool fluctuation caused formation of new pseudo-equilibrium structures with mesomorphic transformations to more fluid and less ordered mesostructures. Replacing up to 50 wt% of the water by glycerol significantly increases the gel phase region in the phase diagram, meaning more structural compositional options. The structural parameters were determined using cross-polarized light microscopy (CPLM), differential scanning calorimeter (DSC), powder X-ray diffraction (PXRD), and small angle X-ray scattering (SAXS). Rheological measurements revealed viscoelastic properties of lyotropic liquid crystals with a decrease in the elasticity (G'), plasticity (GaEuro(3)), and complex viscosity (eta*), as a function of increasing the glycerol content.
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9789004291836 Orality and Textuality in the Iranian World: Patterns of Interaction Across the Centuries Edited by Julia Rubanovich BRILL 2015 456 pages $218.00 Hardcover Jerusalem Studies in Religion and Culture; [...]
How does the content of public allegations impact regulatory communication strategies? Employing a multinomial logistic regression analysis and an original data set, this article analyzes the Israeli banking regulator's nuanced responses to public expressions of opinion between 1996 and 2012. We demonstrate this agency's greater propensity to acknowledge problems, yet mostly shift blame to others when faced with claims that regulation is overly lenient, and to deny allegations that regulation is excessive. These findings, although based on one institution, are important because they demonstrate an agency's differential response to external allegations, given their content and its assessment of the relative threat to its reputation. They also suggest that external audiences may be able to shape agency attention and response by carefully framing their claims in light of their understandings of agencies' distinct reputational vulnerabilities.
A. Binder Gallimidi, Fischman, S. , Revach, B. , Bulvik, R. , Maliutina, A. , Rubinstein, A. M. , Nussbaum, G. , ו Elkin, M.. 2015.
“Periodontal Pathogens Porphyromonas Gingivalis And Fusobacterium Nucleatum Promote Tumor Progression In An Oral-Specific Chemical Carcinogenesis Model”. Oncotarget, 6, 26, Pp. 22613–22623.
Oral squamous cell carcinoma (OSCC) is a lethal disease whose incidence is increasing. Epidemiologic studies demonstrate an association between periodontitis and oral cancer, and periodontal pathogens are implicated in the pathogenesis of numerous disorders, including rheumatoid arthritis, cardiovascular diseases, diabetes and gastrointestinal malignancies. Nevertheless, a causal role for periodontal pathogens in OSCC has not been shown, partly due to the lack of an appropriate animal model. Here, utilizing a newly-established murine model of periodontitis-associated oral tumorigenesis, we report that chronic bacterial infection promotes OSCC, and that augmented signaling along the IL-6-STAT3 axis underlies this effect. Our results indicate that periodontal pathogens P. gingivalis and F. nucleatum stimulate tumorigenesis via direct interaction with oral epithelial cells through Toll-like receptors. Furthermore, oral pathogens stimulate human OSCC proliferation and induce expression of key molecules implicated in tumorigenesis. To the best of our knowledge, these findings represent the first demonstration of a mechanistic role for oral bacteria in chemically induced OSCC tumorigenesis. These results are highly relevant for the design of effective prevention and treatment strategies for OSCC.
A. Wilensky, Tzach-Nahman, R. , Potempa, J. , Shapira, L. , ו Nussbaum, G.. 2015.
“Porphyromonas Gingivalis Gingipains Selectively Reduce Cd14 Expression, Leading To Macrophage Hyporesponsiveness To Bacterial Infection”. J Innate Immun, 7, 2, Pp. 127–135.
Cysteine proteases (gingipains) from Porphyromonas gingivalis are key virulence factors in chronic periodontitis. Innate immune receptors CD14, Toll-like receptor (TLR) 2 and TLR4 are important in P. gingivalis recognition. We examined the ability of gingipains to cleave CD14, TLR2 and TLR4, and the consequences for the cellular response to bacterial challenge. Macrophages were exposed to Arg (RgpA and RgpB)- and Lys (Kgp)-gingipains, and residual expression of TLR2, TLR4 and CD14 was determined by flow cytometry. The cellular response to live bacteria following exposure to purified gingipains was evaluated by TNFα production and bacterial phagocytosis. RgpA and Kgp decreased CD14 detection in a concentration (p = 0.0000002)- and time (p = 0.03)-dependent manner, whereas RgpB had no significant effect. TLR2 and TLR4 expression were unaffected. Reduction in CD14 expression was more efficient with Lys-gingipain than with Arg-gingipain. A reduced CD14 surface level correlated with decreased TNFα secretion and bacterial phagocytosis following challenge with live P. gingivalis, but the response to heat-killed bacteria was unaffected. Therefore, gingipains reduce CD14 expression without affecting expression of the bacterial-sensing TLRs. Reduced CD14 expression depends on the gingipain hemagglutinin/adhesion site and results in macrophage hyporesponsiveness to bacterial challenge. Further studies are needed to determine if reduced CD14 expression is linked to periodontitis induced by P. gingivalis.
Propofol (2,6-diisopropylphenol) is a drug for both induction and maintenance of anesthesia. Pure propofol cannot be injected because of its lipophilic character, low water-solubility, and low bioavailability. Presently, propofol is formulated in an unstable emulsion, easily oxidized, and easily contaminated with bacteria. We are proposing new, propofol-loaded modified microemulsions, stable thermodynamically, and microbiologically safe; the microemulsions are fully dilutable with water. Structural characterization of the empty and the propofol-loaded systems as a function of water dilution was accomplished using advanced analytical tools such as SD-NMR, SAXS, cryo-TEM, DSC, electrical conductivity, and viscosity. Upon water dilution the propofol-loaded concentrate forms swollen reverse micelles that upon further dilution (40 wt% water) progressively transform into a bicontinuous mesophase and then invert (>65 wt% water) into O/W nanodroplets without ``losing'' the solubilized propofol. The drug exhibits strong interactions with the surfactant (DSC and SD-NMR). Propofol increases the size of the microemulsion nanodroplets, but does not modify the microemulsion behavior. Water, ethanol, and PG are essential structural components, but do not interact directly with propofol. (C) 2015 Published by Elsevier B.V.