2021
This paper proposes to break through the current divide between legal proportionality and policy analysis, and suggests that policy-making should and can be conducted in a way that facilitates the proportionality doctrine, while the latter is adapted to the unique goals and practices of policy analysis. Such integration of proportionality in policy analysis can streamline the consideration of fundamental rights in the policy-making process and consequently increase their protection. We further suggest that the proposed integration of proportionality in policy analysis may complement the limitations of courts in performing judicial review of policy, by offering courts procedural criteria, in addition to the often contested substantive criteria. We begin with a brief presentation of the two domains. Next, we review key differences between the practice of judges and policy-analysts, with the aim of designing the stages of policy analysis in a manner that suits its unique characteristics. Drawing on these foundations, we propose broad guidelines for a normative model of policy analysis that accommodates the requirements of proportionality. Lastly, we consider and discuss the implications of this potential development in policy analysis for the practice of judicial review of public policy.
Yinon M. Bar-On, Goldberg, Yair , Mandel, Micha , Bodenheimer, Omri , Freedman, Laurence , Alroy-Preis, Sharon , Ash, Nachman , Huppert, Amit , ו Milo, Ron . 2021.
“Protection Against Covid-19 By Bnt162B2 Booster Across Age Groups”. New England Journal Of Medicine, 385, Pp. 2421-2430.
Yinon M. Bar-On, Goldberg, Yair , Mandel, Micha , Bodenheimer, Omri , Freedman, Laurence , Alroy-Preis, Sharon , Ash, Nachman , Huppert, Amit , ו Milo, Ron . 2021.
“Protection Against Covid-19 By Bnt162B2 Booster Across Age Groups”. New England Journal Of Medicine, 385, Pp. 2421-2430.
Shira Mencer, Kartawy, Maryam , Lendenfeld, Felix , Soluh, Huda , Tripathi, Manish Kumar , Khaliulin, Igor , ו Amal, Haitham . 2021.
“Proteomics Of Autism And Alzheimer's Mouse Models Reveal Common Alterations In Mtor Signaling Pathway.”. Translational Psychiatry, 11, 1, Pp. 480. doi:10.1038/s41398-021-01578-2.
תקציר Autism spectrum disorder (ASD) and Alzheimer's disease (AD) are two different neurological disorders that share common clinical features, such as language impairment, executive functions, and motor problems. A genetic convergence has been proposed as well. However, the molecular mechanisms of these pathologies are still not well understood. Protein S-nitrosylation (SNO), the nitric oxide (NO)-mediated posttranslational modification, targets key proteins implicated in synaptic and neuronal functions. Previously, we have shown that NO and SNO are involved in the InsG3680(+/+) ASD and P301S AD mouse models. Here, we performed large-scale computational biology analysis of the SNO-proteome followed by biochemical validation to decipher the shared mechanisms between the pathologies. This analysis pointed to the mammalian target of rapamycin complex 1 (mTORC1) signaling pathway as one of the shared molecular mechanisms. Activation of mTOR in the cortex of both mouse models was confirmed by western blots that showed increased phosphorylation of RPS6, a major substrate of mTORC1. Other molecular alterations affected by SNO and shared between the two mouse models, such as synaptic-associated processes, PKA signaling, and cytoskeleton-related processes were also detected. This is the first study to decipher the SNO-related shared mechanisms between SHANK3 and MAPT mutations. Understanding the involvement of SNO in neurological disorders and its intersection between ASD and AD might help developing an effective novel therapy for both neuropathologies.
To what extent do perceptions of public opinion effect individual support and political participation in political action? To what extent might media use moderate the role of public opinion in predicting political participation in the digital age? This study investigates these questions by analysing unique data from an experiment and a representative survey designed and conducted at the height of the summer 2011 protests in Israel. This study offers a new analytical model for studying activism by independently and simultaneously examining the direct and indirect effects of perceptions of majority support, individual support and media use on political behaviour. The experimental results suggest that perceptions of public opinion and media use did affect participation in the 2011 social movement. Specifically, increased perception of majority support for the movement led to increased rates of participation. Moreover, media use was inconsequential among those respondents who perceived that a majority of the public supported the protest. Digital media had a moderate effect on the association between perceptions and support for the protest movement, but there was no such effect with respect to mainstream media use. The findings provide new empirical insight into the effects of perceptions of public opinion and media use on political behaviour. In doing so, they help to explain the development of mass protest movements in the digital age and especially the potential effect of perceptions and media use in promoting the evolution of social movements as well as involvement in collective action in the digital age.
This article examines what I call ‘pulsing’ – visible surges of pedestrian activity. It applies a selection of Torsten Hägerstrand’s time-geographic vocabulary in an ethnographic case-study of Mitzpe Ramon, a small Negev Desert town in Israel, illustrating how various spatio-temporal constraints shape flows of walking at daily, weekly, and annual scales. Pulsing, I argue, simply but powerfully communicates when events of collective interest occur, where, for which groups, and at what volumes. Pulsing embodies cultural practices through mobilities, and shapes community norms. Extending beyond this particular example, I also suggest that the concept of pulsing advances understandings of synchrony and synchory in collective pedestrianism and mobilities more broadly, including pilgrimage, urban rhythms, commuter patterns, periodicity, rush hours, and the filling and emptying of public space.
In many auction environments sellers are better informed about bidders' valuations than the bidders themselves. For such environments we derive a sharp and general optimal policy of information transmission in the case of independent private values. Under this policy bidders whose (ex-post) valuation is below a certain threshold are provided with all the information (about their valuations), but those bidders whose valuation lies below the threshold receive no information whatsoever. Surprisingly, the threshold expressed in percentiles is independent of the probability distribution over bidders' ex-post valuations; it depends solely on the number of bidders. Similar results are also derived for the bidder-optimal policy. Our analysis builds on the approach of Bayesian persuasion and on a linearity of sellers' revenues as a function of the inverse distribution. This latter property allows us to use important results on stochastic comparisons.
Zhiyong Chen, Huang, Qian , Song, Xiaodan , Ford, Neil C. , Zhang, Chi , Xu, Qian , Lay, Mark , He, Shao-Qiu , Dong, Xinzhong , Hanani, Menachem , ו Guan, Yun . 2021.
“Purinergic Signaling Between Neurons And Satellite Glial Cells Of Mouse Dorsal Root Ganglia Modulates Neuronal Excitability In Vivo”. Pain, Publish Ahead of Print. doi:10.1097/j.pain.0000000000002556.
Publisher's Version The antituberculosis drug telacebec is ineffective against Mycobacterium abscessus. A recent study suggested that TB47, a telacebec analogue, potentiated the efficacy of clofazimine against M. abscessus. Here, we report that TB47 not only is ineffective against M. abscessus in vitro but also does not potentiate the activity of clofazimine.
Semiconductor nanocrystals are promising photocatalysts for a wide range of applications, ranging from alternative fuel generation to biomedical and environmental applications. This stems from their diverse properties, including flexible spectral tunability, stability, and photocatalytic efficiencies. Their functionality depends on the complex influence of multiple parameters, including their composition, dimensions, architecture, surface coating, and environmental conditions. A particularly promising direction for rapid adoption of these nanoparticles as photocatalysts is their ability to act as photoinitiators (PIs) for radical polymerization. Previous studies served to demonstrate the proof of concept for the use of quantum confined semiconductor nanocrystals as photoinitiators, coining the term Quantum PIs, and provided insights for their photocatalytic mechanism of action. However, these early reports suffered from low efficiencies while requiring purging with inert gases, use of additives, and irradiation by high light intensities with very long excitation durations, which limited their potential for real-life applications. The progress in nanocrystal syntheses and surface engineering has opened the way to the introduction of the next generation of Quantum PIs. Herein, we introduce the research area of nanocrystal photocatalysts, review their studies as Quantum PIs for radical polymerization, from suspension polymerization to novel printing, as well as in a new family of polymerization techniques, of reversible deactivation radical polymerization, and provide a forward-looking view for the challenges and prospects of this field.
המטרה: לבחון את התנסויותיהם של סטודנטים טרנסג'נדרים מן המרכז ומן הפריפריה במרחב ההשכלה הגבוהה. הנבדקים: 20 סטודנטים טרנסג'נדרים יהודים הלומדים בפריפריה או במרכז ישראל. שיטת המחקר: הנבדקים השתתפו במחקר איכותני, שבמסגרתו נערכו ראיונות אישיים. מן הממצאים: ניתוח הראיונות הציף שני עולמות תוכן מרכזיים: מציאות מרחבית ותגובות חברתיות: משא ומתן על ההבדל שבין 'מרכז' ו'פריפריה'; הפריפריה כמרחב המאפשר אקטיביזם קווירי. הסטודנטים שלמדו במוסדות אקדמיים הממוקמים בפריפריה נטו לראות במוסדות אלה מקור לתמיכה ומרחב שאפשר להם להיות פעילים חברתיים "קווירים" שפועלים לשינוי מן השוליים. זאת בניגוד לשיח הרווח במרכז, הרואה עצמו כמקבל כמכליל וכתומך בחברות שוליים, שבפועל מנציח היררכיות חברתיות דרך מיסוד הקהילה הגאה ומניעת האקטיביזם הרדיקלי שחלקה מעוניינת לבטא. עבור הסטודנטים שלמדו בפריפריה, המרחב האקדמי שבו למדו והמעטפת שלו שימשו כזירה לעיצוב הזהות האישית והקולקטיבית דרך אקטיביזם קווירי היות שאקטיביזם זה תרם לתחושת הסוכנות שלהם תוך החלשת תחושת האחרות שלהם. בהמשך לכך, הסטודנטים מן הפריפריה ראו במרחב האקדמי אזור בטוח יותר למיעוטים מגדריים ולמיעוטים אחרים. המחקר שופך אור על האופן שבו הפריפריה המרחבית יכולה לתרום לאקטיביזם הקווירי ולשינוי חברתי, תוך קידום פוליטיקה של זהויות המאפשרת תמיכה, סולידריות ותמיכה בין תתי־קבוצות מודרות מן החברה הכללית. הסבר מושג: קוויר – מונח המתאר זהות מינית ומשמש כקטגוריה לזהויות לכל ההומוסקסואלים, לסביות, ביסקסואלים, טרנסג'נדרים, טרנסקסואלים (להט"ב) ואינטר-סקסואלים. המונח אף משמש לעיתים הטרוסקסואלים, הנוקטים בפרקטיקה מינית שאינה בזרם המרכזי של ההתנהגויות המיניות, כגון פוליאמוריה. התיאוריה הקווירית הינה תיאוריה ביקורתית הדנה במושגי המוזר והחריג בחברה, כשהיא מנגחת את הגדרותיה של האידאולוגיה השלטת למושגים כגון מין, גזע ומגדר.
Since its discovery by F.A.L Clowes, extensive research has been dedicated to identifying the functions of the quiescent center (QC). One of the earliest hypotheses was that it serves a key role in regeneration of the root meristem. Recent works provide support for this hypothesis and began to elucidate the molecular mechanisms underlying this phenomenon. There are two scenarios to consider when assessing the role of the QC in regeneration. One, when the damage leaves the QC intact, and the other, when the QC itself is destroyed. In the first scenario, multiple factors are recruited to activate QC cell division in order to replace damaged cells, but whether the QC has a role in the second scenario is less clear. Using both gene expression studies and following cell division pattern has shown that the QC is assembled gradually, only to appear as a coherent identity late in regeneration. Similar late emergence of the QC was observed during the de novo formation of the lateral root meristem. These observations can lead to the conclusion that the QC has no role in regeneration. However, activities normally occurring in QC cells, such as local auxin biosynthesis, are still found during regeneration but occur in different cells in the regenerating meristem. Thus, we explore an alternative hypothesis, that following destruction of the QC, QC-related gene activity is temporarily distributed to other cells in the regenerating meristem, only coalesce into a distinct cell identity when regeneration is complete.
Forecasters should be tested by the Brier score and not just by the calibration score, which can always be made arbitrarily small. The Brier score is the sum of the calibration score and the refinement score; the latter measures how good the sorting into bins with the same forecast is, and thus attests to expertise. This raises the question of whether one can gain calibration without losing expertise, which we refer to as calibeating. We provide an easy way to calibeat any forecast, by a deterministic online procedure. We moreover show that calibeating can be achieved by a stochastic procedure that is itself calibrated, and then extend the results to simultaneously calibeating multiple procedures, and to deterministic procedures that are continuously calibrated.
Mary Seacole’s memoir Wonderful Adventures is recognized for its negotiation of various genres of Victorian writing, including autobiography, travel writing, the slave narrative, and a burgeoning Caribbean tradition of letters. It is a text which is usually interpreted through conventions of Empire, or through the lens of Postcolonial studies. Attempting to bridge this either/or approach, this article focuses on Seacole’s construction of narrative commonalities: I ask, why would a woman so clearly bent on defying the limitations placed on her by gender and race, and whose achievements appear so exceptionally individual, undergird her narrative with constant references to collective identities — often in their most stereotypical abstractions? To answer this question, I engage in close readings that explore the tension between the typical and the specific though Seacole’s use of terminology, focalization and passive voice, and the repeated use of antiphonal structures such as an AAB pattern. I show how Seacole’s self-representation, and her reference to black communities and individuals, draw on trickster sensibilities, thus expanding previous readings of her text that consider her either subversive or complicit in the imperial project. I suggest that Seacole injects Jamaican and black Atlantic sensibilities into her text, even as she uses Victorian rhetorical devices, making the two traditions complementary — as they seem to be in her life.
March 2021: Ruth S. Wenske is a postdoctoral researcher at the Martin Buber Society of Fellows at the Hebrew University in Jerusalem, where she also serves as head the Africa Unit at the Harry S. Truman Research Institute for the Advancement of Peace. Her main research area is contemporary Anglophone African realism with a focus on self-writing, having published articles on the novels of Chimamanda Adichie, Chinua Achebe, and Binyavanga Wainaina. Her secondary research focus is on the connection between literature and literacy in questions of language and pedagogy, including a joint research project with Makerere University on the implementation of the Mother Tongue reform in Ugandan primary schools. She has taught courses on African literature and culture at the Program of Cultural Studies at the Hebrew University, and at the University of Haifa, where she completed her PhD at the English Department. https://orcid.org/0000-0003-2246-6867
This study examines grocery price differentials across neighborhoods in a large metropolitan area (the city of Jerusalem, Israel). Important variation in access to affordable grocery shopping is documented using CPI data on prices and neighborhood-level credit card expenditure data. Residents of peripheral, nonaffluent neighborhoods are charged some of the highest prices in the city and yet display a low tendency to shop outside their neighborhood. In contrast, residents of affluent, centrally located neighborhoods often benefit from lower grocery prices charged in their own neighborhood while also displaying a high propensity to shop at the hard discount grocers located in the city’s commercial districts. The role of spatial frictions in shaping these patterns is studied within a structural model where households determine their shopping destination and retailers choose prices. The estimated model implies strong spatial segmentation in households’ demand. Counterfactual analyses reveal that alleviating spatial frictions results in considerable benefits to the average resident of the peripheral neighborhoods. At the same time, it barely affects the equilibrium prices charged across the city, and so it does little to benefit households with limited mobility.