@article {004763748490089719840101,
	title = {The effect of serum growth factors and xyloside on molecular aging of proteoglycan in embryonal chick cartilage.},
	journal = {Mechanisms of Ageing and Development},
	volume = {26},
	year = {1984},
	pages = {133 - 147},
	abstract = {The effects of normal human serum, insulin-like growth factor and β-d-xyloside on the synthesis of proteoglycan, as well as their differential effect on the synthesis of chondroitin sulfate and keratan sulfate side-chains, were studied in chick embryonal cartilage. The glycosaminoglycans found in the incubation medium were mainly intact carbohydrate moieties of partially degraded proteoglycan molecules, whereas the tissue-bound glycosaminoglycans were of intact proteoglycan molecules. In incubations with normal human serum, the synthesis of the chondroitin sulfate side-chains of the tissue-bound glycosaminoglycans was preferentially stimulated, while the percentage of medium glycosaminoglycan (out of the total glycosaminoglycan in tissue and medium) was reduced, compared to control incubations. In incubations with insulin-like growth factor, the synthesis of the keratan sulfate side-chains of the tissue-bound glycosaminoglycan was preferentially stimulated, whereas the percentage of t},
	issn = {0047-6374},
	url = {http://search.ebscohost.com/login.aspx?direct=true\&db=edselp\&AN=0047637484900897\&site=eds-live},
	author = {Nevo, Zvi and Lis, Dora and Silbergeld, Aviva and Levin, Shmuel and Zak, Yosef and Zadik, Zvi}
}
