@article {2855504,
	title = {The complex nature of fragile site plasticity and its importance in cancer},
	journal = {Curr Opin Cell Biol},
	volume = {40},
	year = {2016},
	month = {2016 06},
	pages = {131-136},
	abstract = {Common fragile sites (CFSs) are chromosomal regions characterized as hotspots for breakage and chromosomal rearrangements following DNA replication stress. They are preferentially unstable in pre-cancerous lesions and during cancer development. Recently CFSs were found to be tissue- and even oncogene-induced specific, thus indicating an unforeseen complexity. Here we review recent developments in CFS research that shed new light on the molecular basis of their instability and their importance in cancer development.},
	keywords = {Animals, Chromosome Fragile Sites, DNA Replication, Genomic Instability, Humans, Neoplasms, Oncogenes},
	issn = {1879-0410},
	doi = {10.1016/j.ceb.2016.03.017},
	author = {Sarni, Dan and Kerem, Batsheva}
}
