The Eric Roland Chair in Brain SciencesDeptartment of Neurobiology, Institution of Life Sciences, The Edmond and Lily Safra Center For Brain Sciences (ELSC)The Hebrew University of Jerusalem, Edmond J. Safra Campus, Givat RamJerusalem, 91904, Israelhttp://elsc.huji.ac.il/mizrahi/home Research:Laboratory of Neuronal and Circuit PlasticityOur lab is interested in how the brain computes sensory information and how these computations change with the experience of the animal. We study both the structure and the function of neurons mainly in two sensory modalities – olfaction and audition. Our animal model is the mouse.Population Dynamics in the Mouse Primary Auditory CortexSensory processing in the mammalian brain is carried out by large populations of neurons.  We use both single cell electrophysiology and in vivo two-photon calcium imaging in mice to study the functional organization, dynamical principles, and functional plasticity of neural population in the primary auditory cortex.In particular we are interested in understanding how sensory coding changes following learning and following natural experiences that are behaviorally relevant. We have several projects that aim to target and manipulate neuronal subpopulations in the cortex. In particular we combine molecular methods (like viruses and transgenic mice) with electrophysiology and optical physiology. Newborn Neurons in the Olfactory BulbWhile in most parts of the brain new neurons are not generated, few neurogenic niches are maintained also in the adult. One of these regions is the olfactory bulb (OB). Little is known about the functional role of this unique form of network plasticity. We use various genetic tools in combination with in-vivo imaging to study how these neurons develop and maintain, in vivo. Specifically, we use two-photon time lapse imaging and to study periglomerular neurons under various experimental conditions.Publications:See All PublicationsMizrahi, A, Shalev A, Nelken I.  2014.  Single neuron and population coding of natural sounds in auditory cortex. Current Opinion in Neurobiology. 24:103-110.Livneh, Y, Adam Y, Mizrahi A.  2014.  Odor Processing by Adult-Born Neurons. Neuron. :-.Adam, Y, Livneh Y, Miyamichi K, Groysman M, Luo L, Mizrahi A.  2014.  Functional transformations of odor inputs in the mouse olfactory bulb. Frontiers in Neural Circuits. 8