For many years the rhizosphere which is the zone of soil in the vicinity of the roots and which is influenced by the roots is known as a unique soil environment with different physical, biological and chemical properties than those of the bulk soil. Recent advances in measurement techniques and computational capabilities facilitate studies on the influences of rhizosphere properties and processes on water and nutrient flow in this unique soil-root interface. In our lab, we use experimental and computational tools to advance understanding of processes and interactions in the rhizosphere that control water and nutrient transport and uptake. Ultimately, this effort will enhance our ability to manage sustainable agricultural practices, and a platform to design breeding of root systems for changing environmental conditions.