Rina Meidan, Girsh, E. , Mamluk, R. , Levy, N. , ו Farberov, S.. 2016.
“Luteolysis In Ruminants: Past Concepts, New Insights, And Persisting Challenges”. בתוך The Life Cycle Of The Corpus Luteum, Pp. 159 - 182. .
Publisher's Version Dror Alishekevitz, Gingis-Velitski, Svetlana , Kaidar-Person, Orit , Gutter-Kapon, Lilach , Scherer, Sandra D. , Raviv, Ziv , Merquiol, Emmanuelle , Ben-Nun, Yael , Miller, Valeria , Rachman-Tzemah, Chen , Timaner, Michael , Mumblat, Yelena , Ilan, Neta , Loven, David , Hershkovitz, Dov , Satchi-Fainaro, Ronit , Blum, Galia , Sleeman, Jonathan P. , Vlodavsky, Israel , ו Shaked, Yuval . 10/25/2016.
“Macrophage-Induced Lymphangiogenesis And Metastasis Following Paclitaxel Chemotherapy Is Regulated By Vegfr3”. Cell Rep., 17, 5, Pp. 1344–1356. .
Publisher's Version Dror Alishekevitz, Gingis-Velitski, Svetlana , Kaidar-Person, Orit , Gutter-Kapon, Lilach , Scherer, Sandra D, Raviv, Ziv , Merquiol, Emmanuelle , Ben-Nun, Yael , Miller, Valeria , Rachman-Tzemah, Chen , Timaner, Michael , Mumblat, Yelena , Ilan, Neta , Loven, David , Hershkovitz, Dov , Satchi-Fainaro, Ronit , Blum, Galia , Sleeman, Jonathan P, Vlodavsky, Israel , ו Shaked, Yuval . 2016.
“Macrophage-Induced Lymphangiogenesis And Metastasis Following Paclitaxel Chemotherapy Is Regulated By Vegfr3.”. Cell Reports, 17, 5, Pp. 1344–1356. doi:10.1016/j.celrep.2016.09.083.
תקציר While chemotherapy strongly restricts or reverses tumor growth, the response of host tissue to therapy can counteract its anti-tumor activity by promoting tumor re-growth and/or metastases, thus limiting therapeutic efficacy. Here, we show that vascular endothelial growth factor receptor 3 (VEGFR3)-expressing macrophages infiltrating chemotherapy-treated tumors play a significant role in metastasis. They do so in part by inducing lymphangiogenesis as a result of cathepsin release, leading to VEGF-C upregulation by heparanase. We found that macrophages from chemotherapy-treated mice are sufficient to trigger lymphatic vessel activity and structure in naive tumors in a VEGFR3-dependent manner. Blocking VEGF-C/VEGFR3 axis inhibits the activity of chemotherapy-educated macrophages, leading to reduced lymphangiogenesis in treated tumors. Overall, our results suggest that disrupting the VEGF-C/VEGFR3 axis not only directly inhibits lymphangiogenesis but also blocks the pro-metastatic activity of macrophages in chemotherapy-treated mice.
Using temperature-resolved dielectric spectroscopy in the range 25-320 K we investigate the macroscopic response, phase symmetry, and order/disorder states in bulk ferroelectric K1-yLiyTa1-xNbx (KLTN). Four long-range symmetry phases are identified with their relative transitions. Directional analysis of the order/disorder states using Fröhlich entropy indicates global symmetry breaking along the growth axis and an anisotropic dipolar effective thermodynamic behavior, which ranges from disordered to ordered at the same temperature for different directions in the sample. Results indicate that the macroscopic polarization, driven by nanosized polar regions, follows a microscopic perovskite eight-sites lattice model. [ABSTRACT FROM AUTHOR]Copyright of Physical Review B: Condensed Matter & Materials Physics is the property of American Physical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder’s express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
The sociological literature on femicide, compared to intimate partner and other forms of gender violence, is scarce. While feminist sociology has addressed the inaudibility of women, femicide remains invisible. Femicide rates are social facts worthy of sociological attention. Like suicide, femicide has to be defined and analysed according to type. The article postulates possible reasons for the invisibility of the phenomenon, such as the unpleasantness of the subject, scope, its conception as a radical feminist idea, fuzziness, its identification with other concepts like genocide, and methodological difficulties in researching it because of the impossibility of researching dead women first-hand, missing data and the difficulties in comparing data cross-nationally. None of the seven posited hypotheses could account for the dearth of sociological literature on the subject. Suggestions for enhancing the visibility of femicide are made, with a call to unearth the phenomenon and remove its invisibility in sociology.
Excessive exploitation diminishes the capacity of natural resources to withstand environmental stress, increasing their vulnerability to extreme conditions that may trigger abrupt changes. The onset of such events depends on the coincidence of random environmental conditions and the resource state (determining its resilience). Examples include species extinction, ecosystem collapse, disease outburst and climate change induced calamities. The policy response to the catastrophic threat is measured in terms of its effect on the long-term behavior of the resource state. To that end, the L-methodology, developed originally to study autonomous systems, is extended to non-autonomous problems involving catastrophic threats.
Thanks to the application of new technologies such as whole-genome sequencing, analysis of transcriptome and proteome of insect pest to agriculture, great progress has been made in understanding the life style, reproduction, evolution and nuisance to crops caused by insect pests such as aphids, planthoppers, and whiteflies. We believe that time has come to summarize progress and to have a glance over the horizon. In this Book experts in the field discuss novel means to increase the different kinds of resistances of plants to better limit the effects of pest, to understand and disturb the hormonal regulation of embryogenesis, molting, metamorphosis and reproduction, to determine the function of insect genes in diverse processes such as metabolism, interaction with plants, virus transmission, development, and adaptation to a changing environment. The knowledge presented here is discussed with the aim of further improving control strategies of insect pestsman";mso-hansi-theme-font:minor-bidi;mso-bidi-theme-font:minor-bidi; mso-ansi-language:NL;mso-fareast-language:NL;mso-bidi-language:AR-SA">. © Springer International Publishing Switzerland 2016.
F Braido, Scichilone, N, Lavorini, F, Usmani, OS, Dubuske, L, Boulet, LP, Mosges, R, Nunes, C, Sánchez-Borges, M, Ansotegui, IJ, Ebisawa, M, Levi-Schaffer, F, Rosenwasser, LJ, Bousquet, J, Zuberbier, T, ו Canonica, Walter G. 2016.
“Manifesto On Small Airway Involvement And Management In Asthma And Chronic Obstructive Pulmonary Disease: An Interasma (Global Asthma Association - Gaa) And World Allergy Organization (Wao) Document Endorsed By Allergic Rhinitis And Its Impact On Asthma”. Asthma Research And Practice, 2, Pp. 12. doi:10.1186/s40733-016-0027-5.
תקציר Evidence that enables us to identify, assess, and access the small airways in asthma and chronic obstructive pulmonary disease (COPD) has led INTERASMA (Global Asthma Association) and WAO to take a position on the role of the small airways in these diseases. Starting from an extensive literature review, both organizations developed, discussed, and approved the manifesto, which was subsequently approved and endorsed by the chairs of ARIA and GA(2)LEN. The manifesto describes the evidence gathered to date and defines and proposes issues on small airway involvement and management in asthma and COPD with the aim of challenging assumptions, fostering commitment, and bringing about change. The small airways (defined as those with an internal diameter <2 mm) are involved in the pathogenesis of asthma and COPD and are the major determinant of airflow obstruction in these diseases. Various tests are available for the assessment of the small airways, and their results must be integrated to confirm a diagnosis of small airway dysfunction. In asthma and COPD, the small airways play a key role in attempts to achieve disease control and better outcomes. Small-particle inhaled formulations (defined as those that, owing to their size [usually <2 $μ$m], ensure more extensive deposition in the lung periphery than large molecules) have proved beneficial in patients with asthma and COPD, especially those in whom small airway involvement is predominant. Functional and biological tools capable of accurately assessing the lung periphery and more intensive use of currently available tools are necessary. In patients with suspected COPD or asthma, small airway involvement must be assessed using currently available tools. In patients with subotpimal disease control and/or functional or biological signs of disease activity, the role of small airway involvement should be assessed and treatment tailored. Therefore, the choice between large- and small-particle inhaled formulations must reflect the physician's considerations of disease features, phenotype, and response to previous therapy. This article is being co-published in Asthma Research and Practice and the World Allergy Organization Journal.
Yifat Geffen, Appleboim, Alon , Gardner, Richard G. , Friedman, Nir , Sadeh, Ronen , ו Ravid, Tommer . 2016.
“Mapping The Landscape Of A Eukaryotic Degronome”. Molecular Cell, 63, 6, Pp. 1055 - 1065. .
Publisher's Version תקציר SummaryThe ubiquitin-proteasome system (UPS) for protein degradation has been under intensive study, and yet, we have only partial understanding of mechanisms by which proteins are selected to be targeted for proteolysis. One of the obstacles in studying these recognition pathways is the limited repertoire of known degradation signals (degrons). To better understand what determines the susceptibility of intracellular proteins to degradation by the UPS, we developed an unbiased method for large-scale identification of eukaryotic degrons. Using a reporter-based high-throughput competition assay, followed by deep sequencing, we measured a degradation potency index for thousands of native polypeptides in a single experiment. We further used this method to identify protein quality control (PQC)-specific and compartment-specific degrons. Our method provides an unprecedented insight into the yeast degronome, and it can readily be modified to study protein degradation signals and pathways in other organisms and in various settings.
Martyrdom in the Muslim world is increasingly integral to conversations about international security. Over the years, the belief system around self sacrifice has become key to understanding the Middle East and its political relationships with the West, although much of the literature and conversation has been restricted to modern concepts of jihadism. The recent spate of scholarship relating to suicide bombers and jihadists studies these concepts without a broader understanding of the principle of martyrdom. This book expands on the chronology of self-sacrifice within Islam and contextualizes the use of suicide bombings using details of the rise of martyrdom in places such as Iraq, Lebanon, Chechnya, and Pakistan. It historicises the background in which "jihad" has been glorified while also exploring contemporary methods of recruitment, like the use of the internet. The authors pay close attention to the different sects and factions of Islam and the differing interpretations of jihad that accompany these ideologies. In the current political climate, a book that explores martyrdom within the framework of historical perspectives, geographical regions, and the influence of outside cultures is essential.
Mast cells are mostly known for their role in allergic diseases although in recent years it has become clear that they have a role in other diseases and in the body's defense against microbes. In most cases, but especially in allergy, eosinophils are present in the tissue within proximity of mast cells. Due to this spatio-temporal correlation we and others have postulated and described a crosstalk between these two cells, mediated via their released mediators and physical interactions, that is able to modulate each other's function and ultimately the outcome of the allergic inflammatory reaction. This review will focus on the functional unit between mast cells and eosinophils that we have named the "Allergic Effector Unit" and specifically highlight its role in allergy.
M Rubinchik-Stern, Shmuel, M. , Bar, J, Eyal, S, ו Kovo, M. 2016.
“Maternal–Fetal Transfer Of Indocyanine Green Across The Perfused Human Placenta.”. Reprod Toxicol, 62, Pp. 100-5.
Adequate measurement tools are mandatory in order to enable researchers to examine the extent and severity of stigma and develop effective stigma change interventions. However, the theoretical foundations and methodological frameworks in this field are underdeveloped. This chapter highlights the main theoretical and methodological challenges facing this field, and presents a summary of leading scales. Finally, recommendations for further scale development are provided.
