פרסומים

Objective: Individuals with schizophrenia demonstrate cognitive, social cognitive, and motivational deficits that contribute to impairment in real-world functioning. In the current study, we investigated the effects of supplementing computerized neurocognitive training with social cognitive exercises, as compared with neurocognitive training alone. Method: In this ongoing, double-blind, randomized controlled trial of 111 participants with psychosis, we compare the effects of supplementing intensive targeted cognitive training with social cognitive training exercises (TCT + SCT) with the effects of targeted cognitive training alone (TCT-only). Participants were assessed on cognition, symptoms, functional capacity, and functional outcomes, as well as social cognition and measures related to reward processing. Results: Both treatment groups showed significant improvement in multiple cognitive domains and improvement in functional capacity. However, as predicted, TCT + SCT group participa

House prices in Israel have risen since 2008 by as much as 98%. Much of this increase is attributed to low levels of housing supply and housing supply elasticities. In Israel land is frequently owned by the state. This results in heavy government involvement in the housing market through the control of land supply via land tenders. This paper estimates the impact of state owned land on the Israeli housing market focusing on these unusual conditions of land supply. A model for the creation of new housing units is proposed. This incorporates land tenders, enabling the estimation of housing supply dynamics with an accurate measure of public land supply. The model is tested using regional panel data which facilitates the dynamic estimation of national and local supply elasticities and regional spillovers. The paper uses novel data sources resulting in a panel of 45 spatial units over a span of 11 years (2002–2012). Due to the nonstationary nature of the data, spatial panel cointegration methods are used. The empirical results yield estimates of housing supply price elasticities and elasticities with respect to land supply. Results show that housing supply is positively impacted by governmental decisions but the impact is low. Supply elasticity with regard to government land tenders stands at around 0.05 over the short run and 0.08 over the long run. Government policy of offering land in low demand areas and fixing minimum-price tendering does not seem to affect housing supply. Policy implications point to the need for more sensitive management of the delicate balance between public and private source of land in order to mitigate the excesses of demand shocks.

Premature termination codons (PTC) originate from nucleotide substitution introducing an in-frame PTC. They induce truncated, usually non-functional, proteins, degradation of the PTC containing transcripts by the nonsense-mediated decay (NMD) pathway and abnormal exon skipping. Readthrough compounds facilitate near cognate amino-acyl-tRNA incorporation, leading potentially to restoration of a functional full-length protein. Splicing mutations can lead to aberrantly spliced transcripts by creating a cryptic splice site or destroying a normal site. Most mutations result in disruption of the open reading frame and activation of NMD. Antisense oligonucleotides are single stranded short synthetic RNA-like molecules chemically modified to improve their stability and ability to recognize their target RNAs and modify the splice site. This review focuses on recent developments in therapies aiming to improve the health of CF patients carrying nonsense or splicing mutations.

As traffic volumes carried by optical networks continue to grow by tens of percent year over year, we are rapidly approaching the capacity limit of the conventional communication band within a single-mode fiber. New measures such as elastic optical networking, spectral extension to multi-bands, and spatial expansion to additional fiber overlays or new fiber types are all being considered as potential solutions, whether near term or far. In this tutorial paper, we survey the photonic switching hardware solutions in support of evolving optical networking solutions enabling capacity expansion based on the proposed approaches. We also suggest how reconfigurable add/drop multiplexing nodes will evolve under these scenarios and gauge their properties and relative cost scalings. We identify that the switching technologies continue to evolve and offer network operators the required flexibility in routing information channels in both the spectral and spatial domains. New wavelength-selective switch designs can now support greater resolution, increased functionality and packing density, as well as operation with multiple input and output ports. Various switching constraints can be applied, such as routing of complete spatial superchannels, in an effort to reduce the network cost and simplify the routing protocols and managed pathway count. However, such constraints also reduce the transport efficiency when the network is only partially loaded, and may incur fragmentation. System tradeoffs between switching granularity and implementation complexity and cost will have to be carefully considered for future high-capacity SDM–WDM optical networks. In this work, we present the first cost comparisons, to our knowledge, of the different approaches in an effort to quantify such tradeoffs.

As traffic volumes carried by optical networks continue to grow by tens of percent year over year, we are rapidly approaching the capacity limit of the conventional communication band within a single-mode fiber. New measures such as elastic optical networking, spectral extension to multi-bands, and spatial expansion to additional fiber overlays or new fiber types are all being considered as potential solutions, whether near term or far. In this tutorial paper, we survey the photonic switching hardware solutions in support of evolving optical networking solutions enabling capacity expansion based on the proposed approaches. We also suggest how reconfigurable add/drop multiplexing nodes will evolve under these scenarios and gauge their properties and relative cost scalings. We identify that the switching technologies continue to evolve and offer network operators the required flexibility in routing information channels in both the spectral and spatial domains. New wavelength-selective switch designs can now support greater resolution, increased functionality and packing density, as well as operation with multiple input and output ports. Various switching constraints can be applied, such as routing of complete spatial superchannels, in an effort to reduce the network cost and simplify the routing protocols and managed pathway count. However, such constraints also reduce the transport efficiency when the network is only partially loaded, and may incur fragmentation. System tradeoffs between switching granularity and implementation complexity and cost will have to be carefully considered for future high-capacity SDM–WDM optical networks. In this work, we present the first cost comparisons, to our knowledge, of the different approaches in an effort to quantify such tradeoffs.

As traffic volumes carried by optical networks continue to grow by tens of percent year over year, we are rapidly approaching the capacity limit of the conventional communication band within a single-mode fiber. New measures such as elastic optical networking, spectral extension to multi-bands, and spatial expansion to additional fiber overlays or new fiber types are all being considered as potential solutions, whether near term or far. In this tutorial paper, we survey the photonic switching hardware solutions in support of evolving optical networking solutions enabling capacity expansion based on the proposed approaches. We also suggest how reconfigurable add/drop multiplexing nodes will evolve under these scenarios and gauge their properties and relative cost scalings. We identify that the switching technologies continue to evolve and offer network operators the required flexibility in routing information channels in both the spectral and spatial domains. New wavelength-selective switch designs can now support greater resolution, increased functionality and packing density, as well as operation with multiple input and output ports. Various switching constraints can be applied, such as routing of complete spatial superchannels, in an effort to reduce the network cost and simplify the routing protocols and managed pathway count. However, such constraints also reduce the transport efficiency when the network is only partially loaded, and may incur fragmentation. System tradeoffs between switching granularity and implementation complexity and cost will have to be carefully considered for future high-capacity SDM–WDM optical networks. In this work, we present the first cost comparisons, to our knowledge, of the different approaches in an effort to quantify such tradeoffs.

As traffic volumes carried by optical networks continue to grow by tens of percent year over year, we are rapidly approaching the capacity limit of the conventional communication band within a single-mode fiber. New measures such as elastic optical networking, spectral extension to multi-bands, and spatial expansion to additional fiber overlays or new fiber types are all being considered as potential solutions, whether near term or far. In this tutorial paper, we survey the photonic switching hardware solutions in support of evolving optical networking solutions enabling capacity expansion based on the proposed approaches. We also suggest how reconfigurable add/drop multiplexing nodes will evolve under these scenarios and gauge their properties and relative cost scalings. We identify that the switching technologies continue to evolve and offer network operators the required flexibility in routing information channels in both the spectral and spatial domains. New wavelength-selective switch designs can now support greater resolution, increased functionality and packing density, as well as operation with multiple input and output ports. Various switching constraints can be applied, such as routing of complete spatial superchannels, in an effort to reduce the network cost and simplify the routing protocols and managed pathway count. However, such constraints also reduce the transport efficiency when the network is only partially loaded, and may incur fragmentation. System tradeoffs between switching granularity and implementation complexity and cost will have to be carefully considered for future high-capacity SDM–WDM optical networks. In this work, we present the first cost comparisons, to our knowledge, of the different approaches in an effort to quantify such tradeoffs.

Background and Aims: The aim of this research was to examine the effect of sustained and regulated deficit irrigation regimes on vegetative growth, physiological aspects and yield parameters of field-grown Merlot grapevines. Methods and Results: The 4-year trial (2009–2012) in a 13-year-old commercial vineyard of Vitis vinifera cv. Merlot compared the following irrigation treatments: three sustained deficit irrigation treatments and two regulated deficit irrigation treatments. We measured leaf area index and pruning mass to assess vegetative growth, and we recorded stem water potential and gas exchange parameters to examine vine water status. At harvest, we measured yield parameters, crushed berries and analysed must. High water availability during early berry development enhanced vegetative growth and increased berry size and yield. Reducing water supply in order to create a certain level of drought stress during late berry development did not damage yield or berry maturation. Conclusions: Regulated deficit irrigation treatment combining higher irrigation from flowering to bunch closure and lower irrigation from bunch closure to harvest has the potential to generate the best balance between vegetative growth, high yield and wine with enhanced colour and aroma compounds. Significance of the Study: This study demonstrates the implications of skilled irrigation, in particular the specific effect of irrigation alternation at different phenological stages. © 2016 Australian Society of Viticulture and Oenology Inc.

Dental caries, a bacterial biofilm-associated disease, is a prevalent oral health problem. It is a bacterial biofilm-associated disease. Conventional means of combating this disease involves oral hygiene, mostly tooth brushing. Supplementary means of prevention and treatment is often necessary. The use of sustained-release delivery systems, locally applied to the oral cavity appears to be one of the most acceptable avenues for the delivery of antimicrobial agents. Area covered: The development and current approaches of local sustained delivery technologies applied to the oral cavity for treatment and prevention of dental caries is discussed. The use of polymeric drug delivery systems, varnishes, liposomes and nanoparticles is presented. Expert opinion: The use of local sustained-release delivery systems applied to the oral cavity has numerous clinical, pharmacological and toxicological advantages over conventional means. Various sustained-release technologies have been suggested over the course of several years. The current research on oral diseases concentrates predominantly on improving the drug delivery. With progress in pharmaceutical technology, sophisticated controlled-release platforms are being developed. The sustained release concept is innovative and there are few products available for the benefit of all populations. Harmonizing academic research with the dental industry will surely expedite the development and commercialization of more products of such pharmacological nature.

Summary Bacteria resident in the gut of Drosophila modify the fly’s innate chemosensory responses to nutritional stimuli. In effect, the gut microbiome compels the host to forage on food patches that favour particular assemblages of bacteria.

Most apple cultivars are self-sterile and completely dependent on cross-pollination from a different cultivar in order to set fruit. Various insects may be pollinators, but the main one is the honey bee [HB] (Apis mellifera). However, despite the advantages of the honey bee as pollinator of many plants, it is a relatively inefficient pollinator of apple flowers. The main reason for this is the tendency of HBs to visit the apple flower from the side (sideworker), thus “stealing” nectar without touching the flower’s reproductive organs – stamens and stigma. In contrast, a bee that visits the flower from the top (topworker) contacts the flower’s reproductive organs, which results in better pollination. Due to the low pollination efficiency, few seeds are formed, and often the resulting fruit is too small to be of commercial value. Experiments conducted in Israel over the last few years have shown for the first time that adding bumblebees [BB] (Bombus terrestris) into pear orchards improved cross-pollination, thus increasing the number of seeds and subsequently fruit size. The goal of the present work was to test the hypothesis that adding BBs to apple orchards may improve cross-pollination. We found that adding BBs to the HBs in the apple orchard improved pollination in all tested cultivars, especially in ‘Gala’, which naturally suffers from relatively few seeds in the fruit. It appears that the addition of BBs did not only increase the number of pollinating insects in the orchard that could perform cross-pollination, including in the cool mornings and in adverse weather conditions, but that it also changed HB foraging behavior, which resulted in improved cross-pollination and increased efficiency, and subsequently more seeds and larger fruit. The improved pollination was due to the greater mobility of HBs between rows of pollinated cultivar and pollenizer, and to the greater proportion of topworkers, which are more efficient pollinators.

The cytokines interleukin 1β and 6 (IL-1β, IL-6) mediate the acute phase response (APR). In liver, they regulate the secretion of acute phase proteins. Using RNA-seq in primary hepatocytes, we show that these cytokines regulate transcription in a bifurcated manner, leading to both synergistic and antagonistic gene expression. By mapping changes in enhancer landscape and transcription factor occupancy (using ChIP-seq), we show that synergistic gene induction is achieved by assisted loading of STAT3 on chromatin by NF-κB. With IL-6 treatment alone, STAT3 does not efficiently bind 20% of its coordinated binding sites. In the presence of IL-1β, NF-κB is activated, binds a subset of enhancers and primes their activity, as evidenced by increasing H3K27ac. This facilitates STAT3 binding and synergistic gene expression. Our findings reveal an enhancer-specific crosstalk whereby NF-κB enables STAT3 binding at some enhancers while perturbing it at others. This model reconciles seemingly contradictory reports of NF-κB-STAT3 crosstalk.

Post-surgery infections are considered the most challenging complication in the orthopedic and dental field. The local release of antibiotics is evidently highly efficient in delivering the drug to the vicinity of the infected area without the risk of systemic toxicity. Bioactive materials, such as hydroxyapatite (HAp) among other calcium phosphates, are reputed as superior antibiotic vehicles, and combine drug-delivery properties and enhanced osteoconductivity. Here, we report on the single-step electrophoretic deposition (EPD) of drug-loaded HAp nanoparticles (NPs) on titanium implants. This approach provides a purely bioactive coating with drug delivery properties in a simple, economic, and fast process. We synthesized pure HAp NPs with 12.5% and 12.8% loading weight percentages of gentamicin sulfate (Gs) and ciprofloxacin (Cip), and electrophoretically deposited them on a titanium substrate. Furthermore, we co-deposited Gs-HAp and Cip-HAp in one-step to yield a drug-loaded system consisting of two types of antibiotics. The drug- loaded NPs as well as the coatings were carefully characterized. The release profiles of the Gs-HAp and Cip-HAp NP coatings showed prolonged release of up to 10 and 25 days, respectively. The bioactivity test revealed superior bioactivity with enhanced precipitation of HAp crystals along with inorganic minerals, such as Mg2+, Na+, and Cl-. The antibacterial in vitro tests of the Cip and Gs-HAp coatings showed efficient inhibition of Pseudomonas aeruginosa bacteria.