פרסומים

2019
With the steady growth of the human population, food security becomes a prime challenge. Aquaculture is the fastest growing sector providing proteins from an animal source, but outbreaks of infectious diseases repeatedly hamper the production and further development of this sector. Breeding of disease-resistant strains is a desired sustainable solution to this problem. Cyprinid herpes virus-3 (CyHV-3) is a dsDNA virus damaging production of common carp, an important food and ornamental fish. Previously, we have demonstrated successful introgression of CyHV-3 resistance from a feral strain to commercial strains. Here, we used genotyping by sequencing to identify two novel quantitative trait loci (QTLs) for disease survival that map to different linkage groups than two other QTLs that we previously identified. Effects of these four QTLs were validated and further studied in 14 families with various levels of disease resistance. CyHV-3 survival was found to be a quantitative trait conditioned by mild additive QTL effects and by intricate dominant allelic and epistatic QTL–QTL interactions. Both rare feral alleles and alleles common to feral and cultured strains contributed to survival. This and other advantages of feral alleles introgression were demonstrated. These QTLs, which affected survival of individuals within families, had no significant effect on variation in cumulative family % survival, suggesting that more between family variation remains to be explored. Unraveling the underlying genetics of survival is important for enhancing the breeding of resistant strains and our knowledge of disease resistance mechanisms.
Galit Almoznino, Zini, Avraham , Zakuto, Avraham , Zlutzky, Hulio , Bekker, Stav , Shay, Boaz , Haviv, Yaron , Sharav, Yair , ו Benoliel, Rafael . 2019. Muscle Tenderness Score In Temporomandibular Disorders Patients: A Case-Control Study. Journal Of Oral Rehabilitation, 46, Pp. 209 – 218. doi:10.1111/joor.12743. Publisher's Version
Recipe Journal Concepts. 2019. My Recipes. Independently Published.
AM Gouw*, Margulis*, K, Liu, NS, Raman, SJ, Mancuso, A, Toal, GG, Tong, L, Mosley, A, Hsieh, AL, Sullivan, DK, ו others, . 2019. The Myc Oncogene Cooperates With Sterol-Regulated Element-Binding Protein To Regulate Lipogenesis Essential For Neoplastic Growth. Cell Metabolism, 30, 3, Pp. 556–572.
D. Polak, Zigron, A. , Eli-Berchoer, L. , Shapira, L. , ו Nussbaum, G.. 2019. Myd88 Plays A Major Role In The Keratinocyte Response To Infection With Porphyromonas Gingivalis. J. Periodont. Res., 54, 4, Pp. 396–404.
To explore the role of keratinocyte myeloid differentiation primary response 88 (MyD88) expression in the adhesion of Porphyromonas gingivalis to the cells and its subsequent invasion and intracellular survival.\\ Primary mouse keratinocytes from wild-type (WT) or Myd88-/- mice were infected with P gingivalis alone or co-infected with Fusobacterium nucleatum. Bacterial adhesion and invasion were measured using fluorescent microscopy and flow cytometry, and intracellular survival in keratinocytes was quantified by an antibiotic protection assay. Keratinocyte expression of antimicrobial peptides was measured by real-time PCR.\İn the absence of MyD88, P gingivalis adherence, invasion, and intracellular survival were enhanced compared with WT keratinocytes. The presence of F nucleatum during infection increased the adhesion of P gingivalis to WT keratinocytes but reduced the adhesion to Myd88-/- keratinocytes. Fusobacterium nucleatum improved mildly the invasion and survival of P gingivalis in both cell types. Baseline expression of beta-defensin 2, 3, 4 and RegIII-γ was elevated in Myd88-/- keratinocytes compared to WT cells; however, following infection beta-defensin expression was strongly induced in WT cells but decreased dramatically in the MyD88 deficient cells.\İn the absence of MyD88 expression, P gingivalis adhesion to keratinocytes is improved, and invasion and intracellular survival are increased. Furthermore, keratinocyte infection by P gingivalis induces antimicrobial peptide expression in a MyD88-dependent manner. Thus, MyD88 plays a key role in the interaction between P gingivalis and keratinocytes.
Yaakov Kareev, Avrahami, Judith , Goldzweig, Ayelet , Hadar, Daniel , ו Klein, Shira . 2019. Myopic Reactivity In Repeated-Choice: The Case Of Competing With Others For A Scarce, Unevenly Distributed Resource. Journal Of Experimental Psychology: General. doi:10.1037/xge0000676.
S. Dishon, Schumacher-Klinger, A. , Gilon, C. , Hoffman, A. , ו Nussbaum, G.. 2019. Myristoylation Confers Oral Bioavailability And Improves The Bioactivity Of C(Myd 4-4), A Cyclic Peptide Inhibitor Of Myd88. Molecular Pharmaceutics, 16, 4, Pp. 1516-1522. doi:10.1021/acs.molpharmaceut.8b01180. Publisher's Version
Myeloid differentiation primary response 88 (MyD88) is an intracellular adaptor protein central to the signaling of multiple receptors involved in inflammation. Since innate immune inflammation promotes autoimmunity, MyD88 is an attractive target in autoimmune disease. We previously developed c(MyD 4-4), a novel cyclic peptide competitive inhibitor of MyD88 dimerization that is metabolically stable. Parenteral administration of c(MyD 4-4) reduces disease severity in a mouse model of the human autoimmune disease multiple sclerosis. We now show that N-terminal myristoylation of c(MyD 4-4) enhances the competitive inhibition of MyD88 dimerization in living cells, leading to improved inhibition of the Toll-like receptor and IL-1 receptor signaling. Importantly, myristoylation converts c(MyD 4-4) to an orally bioavailable inhibitor of MyD88. Oral administration of c(MyD 4-4) significantly lowered the inflammatory cytokines secreted by peripheral autoimmune T cells in mice immunized with myelin antigens and ameliorated disease severity in the mouse model of multiple sclerosis. Taken together, we show the conversion of a protein active region to a metabolically stable, selective cyclic peptide that is orally bioavailable. © 2019 American Chemical Society.
S. Dishon, Schumacher-Klinger, A. , Gilon, C. , Hoffman, A. , ו Nussbaum, G.. 2019. Myristoylation Confers Oral Bioavailability And Improves The Bioactivity Of C(Myd 4-4), A Cyclic Peptide Inhibitor Of Myd88. Mol. Pharm., 16, 4, Pp. 1516–1522.
Myeloid differentiation primary response 88 (MyD88) is an intracellular adaptor protein central to the signaling of multiple receptors involved in inflammation. Since innate immune inflammation promotes autoimmunity, MyD88 is an attractive target in autoimmune disease. We previously developed c(MyD 4-4), a novel cyclic peptide competitive inhibitor of MyD88 dimerization that is metabolically stable. Parenteral administration of c(MyD 4-4) reduces disease severity in a mouse model of the human autoimmune disease multiple sclerosis. We now show that N-terminal myristoylation of c(MyD 4-4) enhances the competitive inhibition of MyD88 dimerization in living cells, leading to improved inhibition of the Toll-like receptor and IL-1 receptor signaling. Importantly, myristoylation converts c(MyD 4-4) to an orally bioavailable inhibitor of MyD88. Oral administration of c(MyD 4-4) significantly lowered the inflammatory cytokines secreted by peripheral autoimmune T cells in mice immunized with myelin antigens and ameliorated disease severity in the mouse model of multiple sclerosis. Taken together, we show the conversion of a protein active region to a metabolically stable, selective cyclic peptide that is orally bioavailable.
Leona Toker. 2019. Nabokov&Rsquo;S Factography. בתוך Vladimir Nabokov And The Fictions Of Memory, Pp. 21-50. ed. Irena Ksi\k eżopolska and Mikołaj Wiśniewski. Warsaw: Fundacja Augusta hr. Cieszkowskiego. . Publisher's Version תקציר
 Nabokov’s fictional retrospective first-person narratives rely on the “perfect-memory” convention, which is, however, sometimes laid bare or even subverted. This convention makes no inroads in Nabokov’s factorgraphic narratives, such as Speak, Memory and “Abram Gannibal.” This paper discusses the narrative techniques that replace the “perfect-memory” convention in the “childhood-adolescence-youth” part of Speak, Memory, and the way these techniques relate to Nabokov’s view of the workings of memory, in the context of some his literary and philosophical precursors.                                    
Naharaim
2019. Naharaim. Journal Of German-Jewish Literature And Cultural History, 13, 1-2 (Dec 2019). . Publisher's Version
T. Nassar, Rohald, A. , Naraykin, N. , Barasch, D. , Amsalem, O. , Prabhu, P. , Kotler, M. , ו Benita, S.. 2019. Nanocapsules Embedded In Microparticles For Enhanced Oral Bioavailability And Efficacy Of Lopinavir As An Anti-Aids Drug. Journal Of Drug Targeting, 27, 5-6, Pp. 590-600. doi:10.1080/1061186X.2018.1552275. Publisher's Version
Lopinavir (LPV), an efficient drug for HIV infection treatment, was incorporated into biodegradable PLGA nanocapsules (NCs) embedded in microparticles (MCPs) using the spray-drying technique in an attempt to bypass the P-gp efflux and protect the drug from CYP3A pre-systemic metabolism without ritonavir (RTV). SEM observations confirmed the formation of NCs and their entrapment in the MCPs. LPV-loaded NCs and free LPV were released from the MCPs at pH of 7.4 as evidenced by in vitro release studies. Results obtained from rat studies showed a two-fold higher bioavailability of LPV following oral administration of the optimal formulation than Kaletra®, the marketed drug, showing that when properly entrapped, LPV can be effectively protected from CYP degradation in the gut as well as from the liver following systemic absorption. It was also shown that serum derived from rats following LPV oral administration in two formulations and Kaletra® significantly decreased the multiplication of HIV-1 in cultured SupT1 cells. Furthermore, the LPV formulations markedly restricted the titre of infectious HIV-1 production compared with Kaletra® confirming the improved antiviral activity of LPV delivered in the rat blood circulation by the nanocapsules embedded in microparticle formulations. © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group.
Taher Nassar, Rohald, Ayala , Naraykin, Natalya , Barasch, Dinorah , Amsalem, Orit , Prabhu, Ponnandy , Kotler, Moshe , ו Benita, Simon . 2019. Nanocapsules Embedded In Microparticles For Enhanced Oral Bioavailability And Efficacy Of Lopinavir As An Anti-Aids Drug.. Journal Of Drug Targeting, 27, 5-6, Pp. 590–600. doi:10.1080/1061186X.2018.1552275. תקציר
Lopinavir (LPV), an efficient drug for HIV infection treatment, was incorporated into biodegradable PLGA nanocapsules (NCs) embedded in microparticles (MCPs) using the spray-drying technique in an attempt to bypass the P-gp efflux and protect the drug from CYP3A pre-systemic metabolism without ritonavir (RTV). SEM observations confirmed the formation of NCs and their entrapment in the MCPs. LPV-loaded NCs and free LPV were released from the MCPs at pH of 7.4 as evidenced by in vitro release studies. Results obtained from rat studies showed a two-fold higher bioavailability of LPV following oral administration of the optimal formulation than Kaletra(®), the marketed drug, showing that when properly entrapped, LPV can be effectively protected from CYP degradation in the gut as well as from the liver following systemic absorption. It was also shown that serum derived from rats following LPV oral administration in two formulations and Kaletra(®) significantly decreased the multiplication of HIV-1 in cultured SupT1 cells. Furthermore, the LPV formulations markedly restricted the titre of infectious HIV-1 production compared with Kaletra(®) confirming the improved antiviral activity of LPV delivered in the rat blood circulation by the nanocapsules embedded in microparticle formulations.
Qian Zhang, Cohen, Sidney R, Rosenhek-Goldian, Irit , Amgar, Daniel , Bar-Elli, Omri , Tsarfati, Yael , Bendikov, Tatyana , Shimon, Linda JW, Feldman, Yishay , Iron, Mark A, ו others, . 2019. A Nanoscopic View Of Photoinduced Charge Transfer In Organic Nanocrystalline Heterojunctions. The Journal Of Physical Chemistry C, 123, Pp. 25031–25041.
Ban Xuan Dong, Bennington, Peter , Kambe, Yu , Sharon, Daniel , Dolejsi, Moshe , Strzalka, Joseph , Burnett, Veronica F. , Nealey, Paul F. , ו Patel, Shrayesh N.. 2019. Nanothin Film Conductivity Measurements Reveal Interfacial Influence On Ion Transport In Polymer Electrolytes. Molecular Systems Design & Engineering, 4, 3, Pp. 597–608. doi:10.1039/C9ME00011A. Publisher's Version תקציר
Nanoscale interfacial zone limits ion transport properties of polymer electrolytes.

This essay focuses on the various forms of narrating, mediating, and interpreting selves within and around a book object, the novel S. (2013) by J. J. Abrams and Doug Dorst. The novel S. is an experiment in producing a deceivingly realistic replica of a maltreated library book object, but its discursive practices also rely on familiar literary forms, harking back to epistolary commonplaces, as well as to marginalia, both ancient and modern. The book object S., which carries the text of the novel-within-a-novel, the readers’ multilayered markings, and paraphernalia, forms an archive dramatizing the workings of memory, thought, and emotion. That archive also demonstrates how the characters collect, organize, and process data from a variety of media sources. S. also problematizes narration, mediation, and the representation of textual selves through its data overkill verging on unreadability. Modifying Garrett Stewart’s notion, the essay considers the possible significances of narrative “demediation” in experiments with the nearly dysfunctional book form. The very act of demediating signifies conceptually, by its very presence, as conceptual art customarily does. In the case of S., it conceptualizes textual communication and minds in interaction even to a degree of confusion, not-reading, or veritable library silence in reception.

 

February 2019: Mikko Keskinen is Professor of Comparative Literature at the University of Jyväskylä, Finland. He is the author of Response, Resistance, Deconstruction (Jyväskylä UP, 1998) and Audio Book: Essays on Sound Technologies in Narrative Fiction (Lexington Books, 2008). He has published articles on narrative theory, contemporary literature, and experimental writing in Critique, Journal of International Women’s Studies, PsyArt, Romanic Review, Imaginaires, Image [&] Narrative, and Frontiers of Narrative Studies. His book chapters have appeared or are forthcoming in Novels of the Contemporary Extreme (Continuum, 2006), Terrorism, Media, and the Ethics of Fiction (Continuum, 2010), Theory of Mind and Literature (Purdue UP, 2010), and Reconfiguring the Non-Human (Routledge, 2019).

 

Greger Andersson. 2/8/2019. Narrating Selves And The Literary In The Bible. Partial Answers, 17, 1, Pp. 87-105. . Publisher's Version

This article discusses how features in a narrative generate an understanding of its purpose and how this understanding affects our attitude when reading and interpreting a text. It focusses on biblical texts that aspire to be historical but still contain elements that are generally thought to belong to the realm of fiction, as well as on texts with an assumed argumentative purpose and traits that create a sense of literary art. The four texts are Jesus’s parable of the Good Samaritan, the book of Nehemiah, autobiographical sections in Paul, and third-person narratives in the books of Samuel. The article suggests that our understanding of the frame determines the function and meaning of the forms; yet it also argues that the presence of certain forms might challenge conventional assumptions about the frame, that is, the purpose of some narratives.

 

February 2019:

Greger Andersson is Professor in Comparative Literature and head of the research environment Narration, Life, Meaning at Örebro University, Sweden. He has published on narratology and the application of narratology as an analytical method in biblical studies. At present he is working with the theme of sameness or difference in narratology.

 

Matti Hyvaerinen, Hatavara, Mari , ו Mildorf, Jarmila . 2/9/2019. Narrating Selves From The Bible To Social Media: Introduction To The Forum. Partial Answers, 17, 1, Pp. 81-86. . Publisher's Version

 

 

This introduction to the forum “Narrating Selves from the Bible to Social Media” contextualizes the theme by taking recourse to philosopher Alasdair MacIntyre’s reflections on self-narration. MacIntyre poses the question about personal continuity in spite of the necessary change. With his concept of “character,” he makes explicit the connection to literature, thus emphasizing a degree of creativity when people tell their life stories. The contributions to the forum explore this aspect by also highlighting the role of the everyday and the media through which selves are portrayed.

 

Avinoam Rosenak ו Zinger, Sharon Leshem . 2019. Narrativism And The Unity Of Opposites: Theory, Practice, And Exegesis: A Study Of Three Stories From The Talmud. Religions, 10, 6, Pp. 367. doi:10.3390/rel10060367.
Gideon Hen ו Sela-Donenfeld, Dalit . 2019. “A Narrow Bridge Home”: The Dorsal Mesentery In Primordial Germ Cell Migration. Seminars In Cell And Developmental Biology, 92, Pp. 97–104. doi:10.1016/j.semcdb.2018.08.010. תקציר
Specification of primordial germ cells (PGCs) in all vertebrates takes place in extragonadal sites. This requires migration of PGCs through embryonic tissues towards the genital ridges by both passive and active types of migration. Commonly, colonization in the genital ridges follows migration of the PGCs along the thin tissue of the dorsal mesentery. Here we review the anatomy of the dorsal mesentery, the role it plays in migration of PGCs, and the interactions of PGCs with different cell types, extracellular matrix and signaling pathways that are all essential for attraction and orientation of PGCs along the dorsal mesentery towards the gonad anlage.
O. Barazani, Erez, T. , Ogran, A. , Hanin, N. , Barzilai, M. , Dag, A. , ו Shafir, Sharoni . 2019. Natural Variation In Flower Color And Scent In Populations Of Eruca Sativa (Brassicaceae) Affects Pollination Behavior Of Honey Bees. Journal Of Insect Science, 19, 3. doi:10.1093/jisesa/iez038. Publisher's Version תקציר
Plants of Eruca sativa Mill. (Brassicaceae) from desert and Mediterranean populations in Israel differ in flower color and size. In the desert habitat, the population has higher abundance of flowers with cream color and longer petals, whereas in the Mediterranean habitat, the population has higher abundance of flowers with yellow and shorter petals. Choice experiments with honey bee foragers (Apis mellifera Linn., Apidae, Hymenoptera), the main pollinator in the natural habitat in Israel, confirmed that they are more attracted to the yellow flower morph than to the cream one. A proboscis extension response test indicated that honey bees are able to discriminate between flower scents of the desert and Mediterranean populations. Considering the advantage of plants of the yellow morph in attracting pollinators, we further tested in a common garden experiment whether these possess higher fitness than plants of the desert population. Indeed, a significant association was found between flower color and fruit set, and seed mass. In general, our results provide evidence for ecotypic differentiation between populations imposed by pollinators. The advantage of the yellow color morph in attracting pollinators may explain its dominance among plants of the Mediterranean population. We discuss why the cream color morph may be dominant in the desert habitat, considering the possibility of different pollinators, tradeoffs between traits, or pleiotropy. © 2019 The Author(s).