פרסומים

2020
Esther S Brielle, Schneidman-Duhovny, Dina , ו Linial, Michal . 2020. The Sars-Cov-2 Exerts A Distinctive Strategy For Interacting With The Ace2 Human Receptor. Viruses.
The starting point for this compilation is the wish to rethink the concept of antisemitism, race and gender in light of Sartre’s pioneering Réflexions sur la Question Juive seventy years after its publication. The book gathers texts by prestigious scholars from different disciplines in the Humanities and the Social Sciences, with the objective or revisiting this work locating it within the setting of two other pioneering – and we argue, related – publications, namely Simone De Beauvoir’s Le deuxième sexe of 1949 and Franz Fanon’s Peau noire et masques blancs of 1952. This particular and original standpoint sheds new light on the different meanings and political functions of the concept of antisemitism in a political and historical context marked by the post-modern concepts of multi-ethnicity and multiculturalism.
S Ron-Doitch, Soroka, Y, Frusic-Zlotkin, M, Barasch, D, Steinberg, D, ו Kohen, R. 2020. Saturated And Aromatic Aldehydes Originating From Skin And Cutaneous Bacteria Activate The Nrf2-Keap1 Pathway In Human Keratinocytes. Exp Dermatol. תקציר
Skin homeostasis is constantly challenged by environmental factors, affecting its delicate redox balance. The skin is also home to a wide variety of bacterial species, including Staphylococci. The cutaneous redox state is governed by the Nrf2-keap1 pathway, which is responsible for the induction of phase II cytoprotective enzymes, thus sustaining a healthy oxidative state. As part of normal metabolism, both bacteria and cutaneous tissue emit copious amounts of volatile organic compounds (VOCs), one subgroup of which are aldehydes. ?,?-unsaturated aldehydes are known activators of Nrf2-keap1 pathway by direct oxidation of the keap1 protein. However, we did not encounter reports of Nrf2 activation by saturated or aromatic aldehydes, neither bacteria nor skin-derived. We hypothesized that non-?,?-unsaturated aldehydes derived from skin or cutaneous bacteria may act as Nrf2-keap1 pathway activators and therefore afford protection against environmental insults. The saturated aldehydes nonanal and decanal (known skin metabolites) and the aromatic aldehyde benzaldehyde (known skin and Staphylococcus epidermidis metabolite) were shown to induce the Nrf2-keap1 pathway in human keratinocytes. We also identified a newly described aromatic aldehyde, 3-furaldehyde (3-FA), emitted from S. aureus and S. epidermidis cultures, which also activated the pathway. Moreover, Nrf2-keap1 induction led to a significant protection against UVB-induced apoptosis. The mechanism involved in this activation has been partially elucidated. This work emphasizes the importance of cutaneous bacteria, as well as healthy skin lipid peroxidation processes in the maintenance and regulation of the cellular antioxidant response, namely with regard to coping with environmental stressors.
S. Ron-Doitch, Soroka, Y. , Frusic-Zlotkin, M. , Barasch, D. , Steinberg, D. , ו Kohen, R.. 2020. Saturated And Aromatic Aldehydes Originating From Skin And Cutaneous Bacteria Activate The Nrf2-Keap1 Pathway In Human Keratinocytes. Experimental Dermatology. doi:10.1111/exd.14103. Publisher's Version
Skin homeostasis is constantly challenged by environmental factors, affecting its delicate redox balance. The skin is also home to a wide variety of bacterial species, including Staphylococci. The cutaneous redox state is governed by the Nrf2-keap1 pathway, which is responsible for the induction of phase II cytoprotective enzymes, thus sustaining a healthy oxidative state. As part of normal metabolism, both bacteria and cutaneous tissue emit copious amounts of volatile organic compounds (VOCs), one subgroup of which are aldehydes. α,β-unsaturated aldehydes are known activators of Nrf2-keap1 pathway by direct oxidation of the keap1 protein. However, we did not encounter reports of Nrf2 activation by saturated or aromatic aldehydes, neither bacteria nor skin-derived. We hypothesized that non–α,β-unsaturated aldehydes derived from skin or cutaneous bacteria may act as Nrf2-keap1 pathway activators and therefore afford protection against environmental insults. The saturated aldehydes nonanal and decanal (known skin metabolites) and the aromatic aldehyde benzaldehyde (known skin and Staphylococcus epidermidis metabolite) were shown to induce the Nrf2-keap1 pathway in human keratinocytes. We also identified a newly described aromatic aldehyde, 3-furaldehyde (3-FA), emitted from S. aureus and S. epidermidis cultures, which also activated the pathway. Moreover, Nrf2-keap1 induction led to a significant protection against UVB-induced apoptosis. The mechanism involved in this activation has been partially elucidated. This work emphasizes the importance of cutaneous bacteria, as well as healthy skin lipid peroxidation processes in the maintenance and regulation of the cellular antioxidant response, namely with regard to coping with environmental stressors. © 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Rima’a Da’as, Schechter, Chen , ו Qadach, Mowafaq . 2020. School Leaders’ Cognitive Complexity: Impact On The Big 5 Model And Teachers’ Organizational Citizenship Behavior. Journal Of School Leadership, 30, 5, Pp. 398–423.
Maoz Fine. 2020. Science, Diplomacy, And The Red Sea’s Unique Coral Reef: It’s Time For Action. Frontiers In Marine Science. doi:10.3389/fmars.2020.00090. Publisher's Version
Andréas Stauder. 2020. Scripts.. תקציר
Egyptian writing comprises a variety of structurally and historically related scripts (hieroglyphic, hieratic, demotic), distributed according to historically shifting spheres of use. Egyptian scripts are mixed systems that represent both meaning and the sounds of language, allowing for a remarkable variety of historically changing spelling patterns. Hieroglyphic writing had major aesthetic and sacralizing functions, related to its enduring pictoriality. Beyond representing speech, Egyptian writing was also used to express non-linguistic dimensions of meaning. This chapter discusses categories of signs, different types of spellings of words, the roles played by determinatives and classifiers, and the nature of linear hieroglyphs, hieratic, abnormal hieratic, and demotic. It also considers cultural contacts and influences on the various Egyptian scripts, and the eventual process of their obsolescence.
Oluyimika Yanmife Adetola, Onabanjo, Oluseye Olusegun , ו Stark, Aliza H.. 2020. The Search For Sustainable Solutions: Producing A Sweet Potato Based Complementary Food Rich In Vitamin A, Zinc And Iron For Infants In Developing Countries. Scientific African, 8. doi:10.1016/j.sciaf.2020.e00363. תקציר
Deficiencies of vitamin A, zinc and iron are prevalent among infants and young children in developing countries. This is often due to consumption of unfortified cereal-based foods. Two nutritionally balanced sweet potato-based complementary foods containing locally available products were developed to help combat micronutrient deficiencies. Composite flours from orange-fleshed sweet potato (OFSP), soybean and carrots were produced by drying, milling and blending in the ratio of 64.6:34.8:0.7 and 61.3:37.7:1.0, respectively. The formulations were evaluated for nutrient composition and compared with a commercially cereal-based product (Control) and the Codex Alimentarius Commission Guidelines for complementary foods for infants and young children. The newly formulated OFSP-based complementary foods (OFSP-CFs) had higher levels of protein and fat compared to the Control. However, the latter was higher in carbohydrates and energy. The OFSP-CFs met the stipulated values for energy (>= 400 kcal/100 g), protein (>= 15%) and fat (10 - 25%) as specified in the Codex standards. Vitamin A (2057 - 2064 mu g RAE/100 g) and zinc (8.82 - 10.38 mg/100 g) were significantly higher (p < 0.05) than levels in the Control (370 mu g RAE/100 g and 2.5 mg/100 g, respectively). OFSP-CF2 was highest in iron content (9.95 mg/100 g). The newly formulated complementary foods exceeded the minimum recommended standards (at least 50% of daily recommendation in an estimated ration of 50 g) for zinc (>100%) and iron (>70%). Furthermore, the blends contained more than 200% of the requirement for daily vitamin A intake as stipulated in the Codex unlike the Control which only met about 46%. OFSP-CFs could improve the vitamin A, zinc and iron intake of infants and young children better than the Control. They may also serve as a sustainable food-based strategy for reducing vitamin A, iron and zinc deficiency as well as protein-energy malnutrition among infants and young children in Nigeria and other developing countries. (C) 2020 The Authors. Published by Elsevier B.V. on behalf of African Institute of Mathematical Sciences / Next Einstein Initiative.
I. Fradkin, Adams, R. A, Parr, T. , Roiser, J. P, ו Huppert, J.D.. 2020. Searching For An Anchor In An Unpredictable World: A Computational Model Of Obsessive Compulsive Disorder.. Psychological Review.
Isaac Fradkin, Adams, Rick A, Parr, Thomas , Roiser, Jonathan P, ו Huppert, Jonathan D. 2020. Searching For An Anchor In An Unpredictable World: A Computational Model Of Obsessive Compulsive Disorder.. Psychological Review, 127, Pp. 672. . Publisher's Version
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Nofar Lifshitz, Hazanov, Lena , Fine, Maoz , ו Yarden, Oded . 2020. Seasonal Variations In The Culturable Mycobiome Of Acropora Loripes Along A Depth Gradient. Microorganisms, 8, 8. doi:10.3390/microorganisms8081139. Publisher's Version תקציר
Coral associated fungi are widespread, highly diverse and are part and parcel of the coral holobiont. To study how environmental conditions prevailing near the coral-host may affect fungal diversity, the culturable (isolated on potato dextrose agar) mycobiome associated with Acropora loripes colonies was seasonally sampled along a depth gradient in the Gulf of Aqaba. Fragments were sampled from both apparently healthy coral colonies as well as those exhibiting observable lesions. Based on phylogenetic analysis of 197 fungal sequences, Ascomycota were the most prevalent (91.9%). The abundance of fungi increased with increasing water depth, where corals sampled at 25 m yielded up to 70% more fungal colony forming units (CFUs) than those isolated at 6 m. Fungal diversity at 25 m was also markedly higher, with over 2-fold more fungal families represented. Diversity was also higher in lesioned coral samples, when compared to apparently healthy colonies. In winter, concurrent with water column mixing and increased levels of available nutrients, at the shallow depths, Saccharomytacea and Sporidiobolacea were more prevalent, while in spring and fall Trichocomacea (overall, the most prevalent family isolated throughout this study) were the most abundant taxa isolated at these depths as well as at deeper sampling sites. Our results highlight the dynamic nature of the culturable coral mycobiome and its sensitivity to environmental conditions and coral health.
N. Lifshitz, Hazanov, L. , Fine, M. , ו Yarden, O.. 2020. Seasonal Variations In The Culturable Mycobiome Of Acropora Loripes Along A Depth Gradient. Microorganisms, 8, 8, Pp. 1-11.
Amit Benady, Zadik, Sean , Eimerl, Dan , Heymann, Sami , Bergman, Hagai , Israel, Zvi , ו Raz, Aeyal . 2020. Sedative Drugs Modulate The Neuronal Activity In The Subthalamic Nucleus Of Parkinsonian Patients. Scientific Reports, 10, 1. doi:10.1038/s41598-020-71358-3. Publisher's Version
Yakir Preisler, Tatarinov, Fedor , Grünzweig, José , ו Yakir, Dan . 2020. Seeking The &Quot;Point Of No Return&Quot; In The Sequence Of Events Leading To Mortality Of Mature Trees. Plant, Cell & Environmentplant, Cell & Environmentplant Cell Environ, n/a, n/a. . Publisher's Version תקציר
Abstract Drought-related tree mortality is increasing globally, but the sequence of events leading to it remains poorly understood. To identify this sequence, we used a 2016 tree mortality event in a semi-arid pine forest where dendrometry and sap flow measurements were carried out in 31 trees, of which seven died. A comparative analysis revealed three stages leading to mortality. First, a decrease in tree diameter in all dying trees, but not in the surviving trees, 8?months ?prior to the visual signs of mortality? (PVSM; e.g., near complete canopy browning). Second, a decay to near zero in the diurnal stem swelling/shrinkage dynamics, reflecting the loss of stem radial water flow in the dying trees, 6?months PVSM. Third, cessation of stem sap flow 3?months PVSM. Eventual mortality could therefore be detected long before visual signs were observed, and the three stages identified here demonstrated the differential effects of drought on stem growth, water storage capacity and soil water uptake. The results indicated that breakdown of stem radial water flow and phloem function is a critical element in defining the ?point of no return? in the sequence of events leading to mortality of mature trees.
Daria Feldman, Yarden, Oded , ו Hadar, Yitzhak . 2020. Seeking The Roles For Fungal Small-Secreted Proteins In Affecting Saprophytic Lifestyles. Frontiers In Microbiology, 11. doi:10.3389/fmicb.2020.00455. תקציר
Small secreted proteins (SSPs) comprise 40-60% of the total fungal secretome and are present in fungi of all phylogenetic groups, representing the entire spectrum of lifestyles. They are characteristically shorter than 300 amino acids in length and have a signal peptide. The majority of SSPs are coded by orphan genes, which lack known domains or similarities to known protein sequences. Effectors are a group of SSPs that have been investigated extensively in fungi that interact with living hosts, either pathogens or mutualistic systems. They are involved in suppressing the host defense response and altering its physiology. Here, we aim to delineate some of the potential roles of SSPs in saprotrophic fungi, that have been bioinformatically predicted as effectors, and termed in this mini-review as ``effector-like'' proteins. The effector-like Ssp1 from the white-rot fungus Pleurotus ostreatus is presented as a case study, and its potential role in regulating the ligninolytic system, secondary metabolism, development, and fruiting body initiation are discussed. We propose that deciphering the nature of effector-like SSPs will contribute to our understanding of development and communication in saprophytic fungi, as well as help, to elucidate the origin, regulation, and mechanisms of fungal-host, fungal-fungal, and fungal-bacterial interactions.
Gal Sason ו Nussinovitch, Amos . 2020. Selective Protective Coating For Damaged Pomegranate Arils. Food Hydrocolloids, 103. doi:10.1016/j.foodhyd.2020.105647. תקציר
This is the first report on a method to create a selective protective coating (i.e., ``bandage'') to treat only the damaged part of pomegranate arils for shelf-life extension of these ready-to-eat chilled fruit. Implementation of a specific sequence of steps enabled the formation of an edible alginate-based protective gel layer only on the damaged surface of the aril. The consecutive steps included immersion of the arils in a solution containing a crosslinking agent, followed by immersion in an aqueous solution consisting of a polysaccharide, and then drying of the arils at ambient temperature. The selective coating method relies on the difference between the hydrophobic natural aril skin and the hydrophilic damaged parts of the aril. The formed coating was thin, transparent and sensorially undetectable, as demonstrated by triangle test. The formed coating helped preserve product quality and decreased fluid exudation during storage. The straightforward method for creating this selective coating may also be valid for any injured or cut plant tissue.
Asaf Weinstein ו Yekutieli, Daniel . 2020. Selective Sign-Determining Multiple Confidence Intervals With Fcr Control. Statistica Sinica, 30, 1, Pp. 531–555.
Rebecca Notis Dardashti, Kumar, Shailesh , Sternisha, Shawn M. , Reddy, Post Sai , Miller, Brian G. , ו Metanis, Norman . 2020. Selenolysine: A New Tool For Traceless Isopeptide Bond Formation. Chemistry A European Journal , 26, Pp. 4952-4957.
Michal Levy ו Gumpel, Thomas P.. 2020. Self-Efficacy And External Locus Of Control As Predictors Of Participant Roles In Relational Aggression. Journal Of Interpersonal Violence, Pp. 1-26. doi:https://journals.sagepub.com/doi/10.1177/0886260520943733. Publisher's Version
The modernist fascination with the Far East is a well-known phenomenon,
driven among other things by the “decline of the West” zeitgeist. When adopted by peripheral communities involved in nation building, it often served other needs and, in the process, became distorted or disproportioned. This  article focuses on the representation of the Far East in the Hebrew and Yiddish literatures of the interwar years. Its main argument is that the longing for the Far East in these literatures has contributed to their self-fashioning precisely as occidental and modern. Accordingly, this is an intriguing test case that sheds light on how one peripheral culture gazes at another, how one Other gazes at another — as opposed to traditional postcolonial research that tends to examine Self-Other or majority-minority relations. The article proposes the 
term “second-order modernism” to describe the fertile changes and disruptions inherent to the displacement of any modernist model onto a peripheral culture. 
ticotsky_second-order_modernism.pdf