פרסומים

Abstract Cathepsin-K (CTSK) is an osteoclast-secreted cysteine protease that efficiently cleaves extracellular matrices and promotes bone homeostasis and remodeling, making it an excellent therapeutic target. Detection of CTSK activity in complex biological samples using tailored tools such as activity-based probes (ABPs) will aid tremendously in drug development. Here, potent and selective CTSK probes are designed and created, comparing irreversible and reversible covalent ABPs with improved recognition components and electrophiles. The newly developed CTSK ABPs precisely detect active CTSK in mouse and human cells and tissues, from diseased and healthy states such as inflamed tooth implants, osteoclasts, and lung samples, indicating changes in CTSK's activity in the pathological samples. These probes are used to study how acidic pH stimulates mature CTSK activation, specifically, its transition from pro-form to mature form. Furthermore, this study reveals for the first time, why intact cells and cell lysate exhibit diverse CTSK activity while having equal levels of mature CTSK enzyme. Interestingly, these tools enabled the discovery of active CTSK in human osteoclast nuclei and in the nucleoli. Altogether, these novel probes are excellent research tools and can be applied in vivo to examine CTSK activity and inhibition in diverse diseases without immunogenicity hazards.

CEE countries faced significant political, economic, social, and technological transformations over the last four decades. Democratic processes, after relative stabilization, tremble again around polarizing values, populist leaders, or nationalistic ideologies. Online communication, especially social media platforms, play a vital role in shaping how citizens interact with the state, political actors, media, and other citizens. The collection of manuscripts focuses on some of the challenges democratic institutions in the region face, in transforming and sustaining civil society and attempts to capture how the digital media environments mitigate or exacerbate those challenges. Included manuscripts focus on the role that online platforms play in the satisfaction with democracy in the CEE region, the interactions between journalists and political actors, the strategic media coverage of elections, affective polarization and political antagonism, and discursive attempts to discourage young people from civic engagement. 

Having a profound influence on marine and coastal environments worldwide, jellyfish hold significant scientific, economic, and public interest. The predictability of outbreaks and dispersion of jellyfish is limited by a fundamental gap in our understanding of their movement. Although there is evidence that jellyfish may actively affect their position, the role of active swimming in controlling jellyfish movement, and the characteristics of jellyfish swimming behavior, are not well understood. Consequently, jellyfish are often regarded as passively drifting or randomly moving organisms, both conceptually and in process studies. Here we show that the movement of jellyfish is controlled by distinctly directional swimming patterns, which are oriented against the direction of surface gravity waves. Taking a Lagrangian viewpoint from drone videos that allows the tracking of multiple adjacent jellyfish, and focusing the scyphozoan jellyfish Rhopilema nomadica as a model organism, we show that the behavior of individual jellyfish translates into a synchronized directional swimming of the aggregation as a whole. Numerical simulations show that this counter-wave swimming behavior results in biased correlated random-walk movement patterns that reduce the risk of stranding, thus providing jellyfish with an adaptive advantage critical to their survival. Our results emphasize the importance of active swimming in regulating jellyfish movement, and open the way for a more accurate representation in model studies, thus improving the predictability of jellyfish outbreaks and their dispersion, and contributing to our ability to mitigate their possible impact on coastal infrastructure and populations.

From approximately 1500 to 1650, English references to sulfur’s stench focused on sensory indications of hell, demons, and wickedness in worldly environments. Thereafter, most English references to the pungent rock turned proportionately to technics, medicine, and progress. The increasing presence of sulfuric miasma within secularizing applications for fumigations, gunpowder, and industry led to a limiting of the role of sulfur as a signifier of hell within English environments. Due to economic incentives, supernatural discourses on brimstone atmospheres faced semantic dispersion, as sulfur took on a growing number of connotations instead of remaining a significant environmental signifier of the scent of the devil and his toadies. These shifting literary associations for sulfur exemplify the fluctuating powers of the market, religious voices, biopolitical networks, and the state to define what is matter out of place, or what can be considered too environmentally toxic for economic consumption. Revising the prominence of synchronic work in Early Modern Studies that critiques the disenchantment thesis, and redeploying theory from Douglas, Jameson, Greenblatt, Eagleton, and Rancière, this essay highlights connections between the History of Ideas, Environmental Studies, and literary criticism through asserting that the sheer abundance of sulfuric substances in the environment, caused by increased uses for the rock in the coal-fired furnaces of the eighteenth century, added to a literary dislodgment of mystical definitions of sulfur’s smell as signifying evil. As the Industrial Revolution stuffed chimneys with additional sulfur compounds, material encounters with brimstone became common. Continuously taught that sulfur meant profit and purity, reformed English noses found less sin in the smell of acrid sulfur smoke. This analysis portrays that within literatures that included associations to sulfur, the impending Anthropocene was tested, greenwashed, and approved by the masses of the disenchanting English public sphere.

 

August 2023: Andrew Kettler taught at the University of Toronto from 2017 to 2019 before serving as an Ahmanson-Getty Fellow at the University of California, Los Angeles during the 2019-2020 academic year. He is currently serving as Assistant Professor of History at the University of South Carolina-Palmetto College. His work has appeared in Senses and Society, Interface, Human Rights Review, the Journal of American Studies, the Journal of the Canadian Historical Association, Patterns of Prejudice, and the Australian Feminist Law Journal. His monograph, The Smell of Slavery: Olfactory Racism and the Atlantic World (Cambridge University Press, 2020), focuses on the development of racist semantics concerning miasma and the contrasting expansion of aromatic consciousness in the making of subaltern resistance to racialized olfactory discourses of state, religious and slave masters.

How do religious citizens’ election projections influence voter turnout? While previous studies have demonstrated the significant impact of religious orientation on individuals’ general future outlook, little is known about the influence of religion on voters’ electoral expectations and how these expectations affect voter turnout. In this paper, we employ a nuanced conceptual framework of election projections and examine the impact of religion on both the affective and probabilistic aspects of citizens’ expectations regarding election outcomes. Our analysis draws upon original panel survey data collected in two countries, focusing on the 2021 Israeli general elections and the 2022 French presidential elections. The findings reveal a mobilizing effect of religious citizens’ election projections in both Israel and France. Specifically, religious voters tend to have more positive affective forecasts about their projected election outcomes, consequently resulting in increased voter turnout. While affective forecasting plays a significant role in religious citizens’ turnout, probabilistic certitude does not have a similar effect. We discuss the contribution and implications of these findings for research on religion and political behavior.

Abstract Frequencies, magnitudes, and distributions of occurrence can affect the events. The problem can be worse or the solution better if greater frequencies and magnitudes are presented with aggregated distribution in the production system. Indices, hence, are used to assist in decision-making on certain issues. The system formed by Caryocar brasiliense Camb. (Malpighiales: Caryocaraceae), a typical and economically important Brazilian Cerrado tree species, and its several arthropods are adequate to evaluate a new index. This study aimed to test an index to identify the loss and solution sources and their importance in the system's loss or income gain. The index is: Percentage of Importance Indice % I . I . = k s 1 $\times$ c 1 $\times$ d s 1 / $Σ$ k s 1 $\times$ c 1 $\times$ d s 1 + k s 2 $\times$ c 2 $\times$ d s 2 + k s n $\times$ c n $\times$ d s n x 100. T h e % I . I . separated the loss sources [e.g., Edessa rufomarginata De Geer, 1773 (Hemiptera: Pentatomidae) on fruits = 41.90%)] on the percentage of reduction of fruit production (e.g., 0.13%), calculated the attention level (e.g., 0.10/fruit), with a total lost production of 1.35% ($\approx$ 307 total lost fruits). The % I.I. also separated the solution sources [e.g., Zelus armillatus (Lep. and Servi., 1825) (Hemiptera: Reduviidae) = 55.48%), the non-attention level (e.g., Z. armillatus: 0.394 for E. rufomarginata on fruit), with total income gain of 0.56% ($\approx$ 128 total saved fruits) on the natural system (e.g., C. brasiliense trees). This index can calculate losses or the effectiveness of the solutions monetarily. Here I test the % I.I., an index that can detect the key loss and solution sources on the system, which can be applied in some knowledge areas.