פרסומים

2022
Dafna Tener, Lusky-Weisrose, Efrat , Roe, Daniel , Mor, Roni , Sigad, Laura I, Shaharabani, Maggi , Yahia-Zetawy, Yasmin , Qwekiss-Halabi, Salwa , ו Rozenfeld-Tzafar, Nili . 2022. “School Principals Coping With Child Sexual Abuse In Their Schools”. Child Abuse & Neglect, 129, Pp. 105656.
Hanna-Riikka Roine ו Suoranta, Esko . 6/8/2022. “Science Fiction And The Limits Of Narrativizing Environmental Digital Technologies”. Partial Answers, 20, 2, Pp. 297-319. . Publisher's Version תקציר

Contemporary authors of science fiction have taken up the challenge of imagining digital technologies whose functions and effects elude human awareness. Such technologies differ from earlier examples in their environmental aspect, brought on by networks that operate at levels “above” and “below” those of a human subject. Another way to describe environmental digital technologies is through the concept of assemblage, involving not only many forms of human labor and material resources, but also collectivities of entities performing cognitive acts, circulating information, interpretations, and meanings. While these collectivities obviously do involve human subjects pursuing different interests, the way that the assemblage functions as a whole does not correspond to human levels of behavior, perception, or scale.

In this article, we build on the idea of the environmental aspect of digital technologies to examine strategies used in science-fictional attempts to represent in narrative the effects of these technologies on both individual and societal levels. Our case studies, the novels Ancillary Justice (2013) by Ann Leckie and Autonomous (2017) by Annalee Newitz, employ more-or-less technological, individual actor-characters to guide readers to think about the effects of human-technical assemblages within the wider fictional worlds. These novels hinge on the literalization of three literary conventions in their attempts at representing these effects: omniscient narration, character-focalization, and mind-reading of fictional characters.

Through the actor-characters and literalizations, the environmental aspect of digital technologies and their effects are woven into the plots, worldbuilding, and narration of the novels. They are thus able, up to a point, to represent tensions between conscious actors and the various forms within which they operate. However, the novels also illustrate the limits of narrativizing environmental technologies in guiding the readers to think about human-technical assemblages and their effects through forms that remain human-centric in scope — including “gender play” as well as narratives of bildung, quest, and romance. In making the effects of digital technologies accessible for readers, the novels are unable to escape the constraints that the conventions and forms impose.

February 2022: Hanna-Riikka Roine (PhD, literary studies) works as a Postdoctoral Research Fellow funded by the Academy of Finland at the Tampere University and as an affiliated researcher in the consortium Instrumental Narratives. Her current research explores the ways in which our engagement with digital media affects, guides, and shapes our engagement with the possible. Roine is a co-editor of the book The Ethos of Digital Environments: Technology, Literary Theory and Philosophy (2021) and has published articles, for instance, on the ways in which narratological inquiry may be extended towards the machines of computational media. 

February 2022: Esko Suoranta is a Doctoral Researcher at the Department of Languages, University of Helsinki. Esko’s dissertation analyzes how contemporary speculative fiction might build affordances for thinking toward complex, systemic phenomena. His publications discuss power, agency, and transhumanity in the contemporary novels of William Gibson, cognitive assemblages and surveillance capitalism in Malka Older’s Infomocracy and Dave Egger’s The Circle, and utopian/dystopian dynamics in Thomas Pynchon’s Bleeding Edge. Esko received the Alan Nadel Prize for Best Graduate Student Paper for his contribution to the 2019 conference of the International Society for the Study of Narrative. He was co-editor-in-chief for Fafnir – Nordic Journal of Science Fiction and Fantasy Research between 2019-2022, in which capacity he won the 2020 World Fantasy Award.

JC Bernauer, Dean, CT , Fanelli, C, Huang, J, Kauder, K, Lawrence, D, Osborn, JD , Paus, C, Adkins, JK , Akiba, Y, ו others, . 2022. “Scientific Computing Plan For The Ecce Detector At The Electron Ion Collider”. Arxiv Preprint Arxiv:2205.08607.
JC Bernauer, Dean, CT , Fanelli, C, Huang, J, Kauder, K, Lawrence, D, Osborn, JD , Paus, C, Adkins, JK , Akiba, Y, ו others, . 2022. “Scientific Computing Plan For The Ecce Detector At The Electron Ion Collider”. Arxiv Preprint Arxiv:2205.08607.
J-L Zhang, Mantry, S, Adkins, JK , Akiba, Y, Albataineh, A, Amaryan, M, Arsene, IC , Gayoso, Ayerbe C, Bae, J, Bai, X, ו others, . 2022. “Search For $ E$\Backslash$To$\Backslash$Tau $ Charged Lepton Flavor Violation At The Eic With The Ecce Detector”. Arxiv Preprint Arxiv:2207.10261.
J-L Zhang, Mantry, S, Adkins, JK , Akiba, Y, Albataineh, A, Amaryan, M, Arsene, IC , Gayoso, Ayerbe C, Bae, J, Bai, X, ו others, . 2022. “Search For $ E$\Backslash$To$\Backslash$Tau $ Charged Lepton Flavor Violation At The Eic With The Ecce Detector”. Arxiv Preprint Arxiv:2207.10261.
This letter documents a search for flavour-changing neutral currents (FCNCs), which are strongly suppressed in the Standard Model, in events with a photon and a top quark with the ATLAS detector. The analysis uses data collected in $pp$ collisions at $\sqrt\s\ = 13$ TeV during Run 2 of the LHC, corresponding to an integrated luminosity of 139 fb$^\-1\$. Both FCNC top-quark production and decay are considered. The final state consists of a charged lepton, missing transverse momentum, a $b$-tagged jet, one high-momentum photon and possibly additional jets. A multiclass deep neural network is used to classify events either as signal in one of the two categories, FCNC production or decay, or as background. No significant excess of events over the background prediction is observed and 95% CL upper limits are placed on the strength of left- and right-handed FCNC interactions. The 95% CL bounds on the branching fractions for the FCNC top-quark decays, estimated from both top-quark production and decay, are $\mathcal\B\(t\rightarrow u\gamma) < 0.85 \times 10^\-5\$ and $\mathcal\B\(t\to c\gamma) < 4.2 \times 10^\-5\$ for a left-handed $tq\gamma$ coupling, and $\mathcal\B\(t\to u\gamma) < 1.2 \times 10^\-5\$ and $\mathcal\B\(t\to c\gamma) < 4.5 \times 10^\-5\$ for a right-handed coupling.
Emeline Charbonnel, Daguin-Thiébaut, Claire , Caradec, Lucille , Moittié, Eléonore , Gilg, Olivier , Gavrilo, Maria V, Strøm, Hallvard , Mallory, Mark L, Morrison, Guy RI, Gilchrist, Grant H, Leblois, Raphael , Roux, Camille , Yearsley, Jonathan M, Yannic, Glenn , ו Broquet, Thomas . 2022. “Searching For Genetic Evidence Of Demographic Decline In An Arctic Seabird: Beware Of Overlapping Generations”. Heredity (Edinb.), 128, 5, Pp. 364–376. תקציר
Genetic data are useful for detecting sudden population declines in species that are difficult to study in the field. Yet this indirect approach has its own drawbacks, including population structure, mutation patterns, and generation overlap. The ivory gull (Pagophila eburnea), a long-lived Arctic seabird, is currently suffering from rapid alteration of its primary habitat (i.e., sea ice), and dramatic climatic events affecting reproduction and recruitment. However, ivory gulls live in remote areas, and it is difficult to assess the population trend of the species across its distribution. Here we present complementary microsatellite- and SNP-based genetic analyses to test a recent bottleneck genetic signal in ivory gulls over a large portion of their distribution. With attention to the potential effects of population structure, mutation patterns, and sample size, we found no significant signatures of population decline worldwide. At a finer scale, we found a significant bottleneck signal at one location in Canada. These results were compared with predictions from simulations showing how generation time and generation overlap can delay and reduce the bottleneck microsatellite heterozygosity excess signal. The consistency of the results obtained with independent methods strongly indicates that the species shows no genetic evidence of an overall decline in population size. However, drawing conclusions related to the species' population trends will require a better understanding of the effect of age structure in long-lived species. In addition, estimates of the effective global population size of ivory gulls were surprisingly low ( 1000 ind.), suggesting that the evolutionary potential of the species is not assured.
Zheng Wang, Lopez-Giraldez, Francesc , Slot, Jason , Yarden, Oded , Trail, Frances , ו Townsend, Jeffrey P.. 2022. “Secondary Metabolism Gene Clusters Exhibit Increasingly Dynamic And Differential Expression During Asexual Growth, Conidiation, And Sexual Development In Neurospora Crassa”. Msystems, 7, 3, Pp. e00232-22. doi:10.1128/msystems.00232-22. Publisher's Version תקציר
Secondary metabolites (SMs) are low-molecular-weight compounds that often mediate interactions between fungi and their environments. Fungi enriched with SMs are of significant research interest to agriculture and medicine, especially from the aspects of pathogen ecology and environmental epidemiology. Secondary metabolite clusters (SMCs) encode the machinery for fungal toxin production. However, understanding their function and analyzing their products requires investigation of the developmental and environmental conditions in which they are expressed. Gene expression is often restricted to specific and unexamined stages of the life cycle. Therefore, we applied comparative genomics analyses to identify SMCs in Neurospora crassa and analyzed extensive transcriptomic data spanning nine independent experiments from diverse developmental and environmental conditions to reveal their life cycle-specific gene expression patterns. We reported 20 SMCs comprising 177 genes—a manageable set for investigation of the roles of SMCs across the life cycle of the fungal model N. crassa—as well as gene sets coordinately expressed in 18 predicted SMCs during asexual and sexual growth under three nutritional and two temperature conditions. Divergent activity of SMCs between asexual and sexual development was reported. Of 126 SMC genes that we examined for knockout phenotypes, al-2 and al-3 exhibited phenotypes in asexual growth and conidiation, whereas os-5, poi-2, and pmd-1 exhibited phenotypes in sexual development. SMCs with annotated function in mating and crossing were actively regulated during the switch between asexual and sexual growth. Our discoveries call for attention to roles that SMCs may play in the regulatory switches controlling mode of development, as well as the ecological associations of those developmental stages that may influence expression of SMCs. IMPORTANCE Secondary metabolites (SMs) are low-molecular-weight compounds that often mediate interactions between fungi and their environments. Fungi enriched with SMs are of significant research interest to agriculture and medicine, especially from the aspects of pathogen ecology and environmental epidemiology. However, SM clusters (SMCs) that have been predicted by comparative genomics alone have typically been poorly defined and insufficiently functionally annotated. Therefore, we have investigated coordinate expression in SMCs in the model system N. crassa, and our results suggest that SMCs respond to environmental signals and to stress that are associated with development. This study examined SMC regulation at the level of RNA to integrate observations and knowledge of these genes in various growth and development conditions, supporting combining comparative genomics and inclusive transcriptomics to improve computational annotation of SMCs. Our findings call for detailed study of the function of SMCs during the asexual-sexual switch, a key, often-overlooked developmental stage.
Magazine Articles
the_secular_gospel.pdf
Michal Ben-Israel, Armon, Moshe , ו Matmon, Ari . 2022. “Sediment Residence Times In Large Rivers Quantified Using A Cosmogenic Nuclides Based Transport Model And Implications For Buffering Of Continental Erosion Signals”. Journal Of Geophysical Research: Earth Surface, 127, Pp. 1–14. doi:10.1029/2021JF006417. תקציר
The weathering of continental surfaces and the transport of sediments via rivers into the oceans is an integral part of the dynamic processes that shape the Earth's surface. To understand how tectonic and climatic forcings control regional rates of weathering, we must be able to identify their effects on sedimentary archives over geologic timescales. Cosmogenic nuclides are a valuable tool to study rates of surface processes and have long been applied in fluvial systems to quantify basin-wide erosion rates. However, in large rivers, continual processes of erosion and deposition during sediment transport make it difficult to constrain how long sediments spend within the fluvial system. In this study, we examine the role of rivers in buffering erosional signals by constraining the timescales of fluvial transport in large rivers across the world. We apply a stochastic numerical model based on measurements of cosmogenic nuclides concentrations and calculate sediment residence times of 104–105 years in large rivers. These timescales are equal to or longer than climatic cycles, implying that changes to rates of erosion brought on by climatic variations are buffered during transport in large rivers and may not be recognizable in the sedimentary record.
Stefan Wagner, Santner, Jakob , Irrgeher, Johanna , Puschenreiter, Markus , Happel, Steffen , ו Prohaska, Thomas . 2022. “Selective Diffusive Gradients In Thin Films (Dgt) For The Simultaneous Assessment Of Labile Sr And Pb Concentrations And Isotope Ratios In Soils”. Anal. Chem., 94, 16, Pp. 6338–6346. תקציר
A method using diffusive gradients in thin films (DGT) for the accurate quantification of trace-level ($μ$g L-1) Sr and Pb concentrations and isotope ratios [$δ$SRM 987(87Sr/86Sr) and $δ$SRM 981(207Pb/206Pb)] in labile, bioavailable element fractions in soils is reported. The method is based on a novel poly(tetrafluoroethylene) (PTFE) membrane binding layer with combined di(2-ethyl-hexyl)phosphoric acid (HDEHP) and 4,4'(5')-bis-t-butylcyclohexano-18-crown-6 (crown-ether) functionality with high selectivity for Sr and Pb (TK100 membrane). Laboratory evaluation of the TK100 DGT showed linear uptake of Sr over time (2-24 h) up to very high Sr mass loadings on TK100 membranes (288 $μ$g cm-2) and effective performance in the range of pH (3.9-8.2), ionic strength (0.001-0.1 mol L-1), and cation competition (50-160 mg L-1 Ca in a synthetic soil solution matrix) of environmental interest. Selective three-step elution of TK100 membranes using hydrochloric acid allowed us to obtain purified Sr and Pb fractions with adequate ($\geq$75%) recovery and quantitative ($\geq$96%) matrix reduction. Neither DGT-based sampling itself nor selective elution or mass loading effects caused significant isotopic fractionation. Application of TK100 DGT in natural soils and comparison with conventional approaches of bioavailability assessment demonstrated the method's unique capability to obtain information on Sr and Pb resupply dynamics and isotopic variations with low combined uncertainty within a single sampling step.
Ei Kusahana, Uchiyama, Kiyotaka , Yamaguchi, Nobuko , Hirashima, Maiko , Togashi, Tomoko , Yamamoto, Yuriko , Imai, Michiyo , Ashida, Mayumi , Yamamura, Keiko , Nakayama, Takashin , Yasuda, Itaru , Morimoto, Kohkichi , Washida, Naoki , ו Itoh, Hiroshi . 2022. “Self-Assessment Sheet Submission Rate Predicts Technique Survival In Patients Initiating Peritoneal Dialysis”. Nephrology (Carlton), 27, 6, Pp. 501–509. תקציר
AIM: Patients play a crucial role in preventing peritoneal dialysis (PD)-related events, including peritonitis and fluid overload, as PD procedures are mainly carried out at home. We asked patients to submit a PD self-assessment sheet at each outpatient visit in our daily clinical practice and evaluated its usefulness for outcomes in patients initiating PD. METHODS: This retrospective cohort study included patients who underwent PD catheter insertion between January 2008 and October 2018. The submission rate of a PD self-assessment sheet was calculated from medical records until PD cessation or study completion (October 2020). The association between the submission rate and technique survival was analysed. RESULTS: Among the 105 recruited patients (78 men, 60.4 $\pm$ 12.2 years), 44 discontinued PD and transferred to haemodialysis during the study period. The follow-up was 52.3 (28.7-79.3) months, and the median submission rate was 78%. The log-rank test showed that technique survival was significantly better in patients with a submission rate $\geq$ 78% than those with a submission rate <78% (p = .006). The submission rate remained significantly associated with less technique failure (hazard ratio 0.88 per 10
Dana Lassri ו Gewirtz-Meydan, Ateret . 2022. “Self-Compassion Moderates The Mediating Effect Of Self-Criticism In The Link Between Childhood Maltreatment And Psychopathology”. Journal Of Interpersonal Violence, 37, Pp. NP21699–NP21722.
Michal Levy ו Gumpel, Thomas P.. 2022. “Self-Efficacy And External Locus Of Control As Predictors Of Participant Roles In Relational Aggression”. Journal Of Interpersonal Violence, 37, 5-6, Pp. NP3015-NP3040. doi:10.1177/0886260520943733. Publisher's Version תקציר
We examined the extent to which the perceived behavioral control factors of pro-social, emotional, or verbal-social self-efficacy (SE) as well as external locus of control (LOC) explain the variance between different participant roles: relational aggressors, relational victims, relational aggressive-victims, and bystanders. Participants included 1,518 adolescents (61.6% boys and 38.4% girls) from 15 Israeli middle and high schools. Multinomial logistic regression models indicated relational aggressors, and aggressive-victims had lower pro-social SE and higher verbal-social SE than relational victims and bystanders. Relational aggressors, aggressive-victims, and victims had more extensive external LOC than bystanders. The theoretical contribution of verbal-social SE is discussed, and practical implications are highlighted, in particular, regarding the relational aggressive-victim, who exhibits high-risk behaviors.
Stener Lie, Bruno, Annalisa , Wong, Lydia Helena, ו etgar, lioz . 2022. “Semitransparent Perovskite Solar Cells With ≫ 13% Efficiency And 27% Transperancy Using Plasmonic Au Nanorods”. Acs Appl. Mater. Interfaces, 2022, 14, Pp. 11339–11349.
acsami.1c22748.pdf
D. Kolodkin-Gal, Roitman, L. , Ovadya, Y. , Azazmeh, N. , Assouline, B. , Schlesinger, Y. , Kalifa, R. , Horwitz, S. , Khalatnik, Y. , Hochner-Ger, A. , Imam, A. , Demma, J. A. , Winter, E. , Benyamini, H. , Elgavish, S. , Khatib, A. A. , Meir, K. , Atlan, K. , Pikarsky, E. , Parnas, O. , Dor, Y. , Zamir, G. , Ben-Porath, I. , ו Krizhanovsky, V.. 2022. “Senolytic Elimination Of Cox2-Expressing Senescent Cells Inhibits The Growth Of Premalignant Pancreatic Lesions”. Gut, 71, Pp. 345-355. . PubMed
Co-authorship Initial analysis differential expression advanced analysis GSEA
תקציר
OBJECTIVE: Cellular senescence limits tumourigenesis by blocking the proliferation of premalignant cells. Additionally, however, senescent cells can exert paracrine effects influencing tumour growth. Senescent cells are present in premalignant pancreatic intraepithelial neoplasia (PanIN) lesions, yet their effects on the disease are poorly characterised. It is currently unknown whether senolytic drugs, aimed at eliminating senescent cells from lesions, could be beneficial in blocking tumour development. DESIGN: To uncover the functions of senescent cells and their potential contribution to early pancreatic tumourigenesis, we isolated and characterised senescent cells from PanINs formed in a Kras-driven mouse model, and tested the consequences of their targeted elimination through senolytic treatment. RESULTS: We found that senescent PanIN cells exert a tumour-promoting effect through expression of a proinflammatory signature that includes high Cox2 levels. Senolytic treatment with the Bcl2-family inhibitor ABT-737 eliminated Cox2-expressing senescent cells, and an intermittent short-duration treatment course dramatically reduced PanIN development and progression to pancreatic ductal adenocarcinoma. CONCLUSIONS: These findings reveal that senescent PanIN cells support tumour growth and progression, and provide a first indication that elimination of senescent cells may be effective as preventive therapy for the progression of precancerous lesions.
Anat Talmon, Cohen, Noa , Raif, Yael , ו Ginzburg, Karni . 2022. “Sense Of Mastery Among Older Adults And Its Relation To Invalidating Childhood Experiences”. Aging & Mental Health, 26, Pp. 2186–2194.
David Shulman. 2022. Sensitive Reading: The Pleasures Of South Asian Literature In Translation. ארצות הברית: University of California Press. doi:10.1525/luminos.114. תקציר
What are the pleasures of reading translations of South Asian literature, and what does it take to enjoy a translated text? This volume provides opportunities to explore such questions by bringing together a whole set of new translations by David Shulman, noted scholar of South Asia. The translated selections come from a variety of Indian languages, genres, and periods, from the classical to the contemporary. The translations are accompanied by short essays written to help readers engage and enjoy them. Some of these essays provide background to enhance reading of the translation, whereas others model how to expand appreciation in comparative and broader ways. Together, the translations and the accompanying essays form an essential guide for people interested in literature and art from South Asia.