פרסומים

Was sehen wir in unserer Stadt? Werbung, Läden, Häuser. Und wo bleiben wir – die Menschen, die in Berlin leben?

Mehr Sichtbarkeit, mehr Teilhabe am und im öffentlichen Raum für Bewohner – das will die Aktion „Du bist am Zug“.

Was sehen wir in unserer Stadt? Werbung, Läden, Häuser. Und wo bleiben wir – die Menschen, die in Berlin leben?

Mehr Sichtbarkeit, mehr Teilhabe am und im öffentlichen Raum für Bewohner – das will die Aktion „Du bist am Zug“.

The immune system interacts with many nominal 'danger' signals, endogenous danger-associated (DAMP), exogenous pathogen (PAMP) and allergen (AAMP)-associated molecular pattern molecules. The immune context under which these are received can promote or prevent immune activating or inflammatory mechanisms and may orchestrate diverse immune responses in allergy and cancer. Each can act either by favouring a respective pathology or by supporting the immune response to confer protective effects, depending on acuity or chronicity. In this Position Paper under the collective term danger signals or DAMPs, PAMPs, and AAMPs, we consider their diverse roles in allergy and cancer and the connection between these in AllergoOncology. We focus on their interactions with different immune cells of the innate and adaptive immune system and how these promote immune responses with juxtaposing clinical outcomes in allergy and cancer. While danger signals present potential targets to overcome inflammatory responses in allergy, these may be reconsidered in relation to a history of allergy, chronic inflammation and autoimmunity linked to the risk of developing cancer, and with regards to clinical responses to anti-cancer immune and targeted therapies. Cross-disciplinary insights in AllergoOncology derived from dissecting clinical phenotypes of common danger signal pathways may improve allergy and cancer clinical outcomes.

Children's exposure to intimate partner violence (IPV) is a serious problem that has been increasingly examined during the last four decades. In the case of severe IPV, children are placed with their mothers in shelters for women survivors of domestic violence (SDV). The current study aimed to understand young children's descriptions of relating with their fathers during their stay in SDVs. Interviews were conducted with 32 Israeli children, aged 7 to 12 years. Two main themes and five subthemes were identified through thematic analysis: (1) Atypical visiting arrangements (subthemes: a lack of understanding about the meaning of supervised visitations, inconsistent and unstable visitations); (2) ambivalent attitudes towards the visiting arrangements (subthemes: enjoying fathers' attention and shared family time, worry and guilt following the visitations, controversial messages from fathers). The findings demonstrate the children's subjective views and emphasize the benefit of gathering qualitative data from young children in the context of exposure to IPV. Findings are discussed in light of the cognitive dissonance reduction theory. Limitations of the study are discussed, along with implications for practice, theory and future research.

Aminoglycosides are an important class of antibiotics that play a critical role in the treatment of life-threatening infections, but their use is limited by their toxicity. In fact, gentamicin causes severe nephrotoxicity in 17% of hospitalized patients. The kidney proximal tubule is particularly vulnerable to drug-induced nephrotoxicity due to its role in drug transport. In this work, we developed a perfused vascularized model of human kidney tubuloids integrated with tissue-embedded microsensors that track the metabolic dynamics of aminoglycoside-induced renal toxicity in real time. Our model shows that gentamicin disrupts proximal tubule polarity at concentrations 20-fold below its TC50, leading to a 3.2-fold increase in glucose uptake, and reverse TCA cycle flux culminating in a 40-fold increase in lipid accumulation. Blocking glucose reabsorption using the SGLT2 inhibitor empagliflozin significantly reduced gentamicin toxicity by 10-fold. These results demonstrate the utility of sensor-integrated kidney-on-chip platforms to rapidly identify new metabolic mechanisms that may underly adverse drug reactions. The results should improve our ability to modulate the toxicity of novel aminoglycosides. © 2022 The Royal Society of Chemistry.