Citation:
Ameer Bishara, Meir, Michal , Portnoy, Emma , Shmuel, Miri , ו Eyal, Sara . 2015. “Near Infrared Imaging Of Indocyanine Green Distribution In Pregnant Mice And Effects Of Concomitant Medications.”. Molecular Pharmaceutics, 12, 9, Pp. 3351–3357. doi:10.1021/acs.molpharmaceut.5b00374.
תקציר:
{The transfer of indocyanine green (ICG) across the placenta is considered to be very low based on measurements in fetal blood. The goal of this study was to evaluate in mice ICG's distribution within fetuses themselves and effects of concomitant medications on fetal exposure. Mid-gestational (day 12.5) and late-gestational (day 17.5) age mice were imaged after administration of ICG (0.167 mg), in the presence and the absence of the organic anion transporting polypeptide (OATP) inhibitor rifampin (10 mg/kg