Citation:
Tzur, Y. B., Wilson, K. L., & Gruenbaum, Y. . (2006). SUN-domain proteins: ’Velcro’ that links the nucleoskeleton to the cytoskeleton.. Nat Rev Mol Cell Biol, 7(10), 782-8. presented at the 2006 Oct. doi:10.1038/nrm2003
Date Published:
2006 OctAbstract:
The novel SUN-domain family of nuclear envelope proteins interacts with various KASH-domain partners to form SUN-domain-dependent ’bridges’ across the inner and outer nuclear membranes. These bridges physically connect the nucleus to every major component of the cytoskeleton. SUN-domain proteins have diverse roles in nuclear positioning, centrosome localization, germ-cell development, telomere positioning and apoptosis. By serving both as mechanical adaptors and nuclear envelope receptors, we propose that SUN-domain proteins connect cytoplasmic and nucleoplasmic activities.