SUN-domain and KASH-domain proteins during development, meiosis and disease.

Citation:

Fridkin, A., Penkner, A., Jantsch, V., & Gruenbaum, Y. . (2009). SUN-domain and KASH-domain proteins during development, meiosis and disease. Cell Mol Life Sci, 66(9), 1518-33. presented at the 2009 May. doi:10.1007/s00018-008-8713-y

Date Published:

2009 May

Abstract:

SUN-domain proteins interact directly with KASH-domain proteins to form protein complexes that connect the nucleus to every major cytoskeleton network. SUN-KASH protein complexes are also required for attaching centrosomes to the nuclear periphery and for alignment of homologous chromosomes, their pairing and recombination in meiosis. Other functions that require SUN-domain proteins include the regulation of apoptosis and maturation and survival of the germline. Laminopathic diseases affect the distribution of the SUN-KASH complexes, and mutations in KASH-domain proteins can cause Emery Dreifuss muscular dystrophy and recessive cerebellar ataxia. This review describes our current knowledge of the role of SUN-KASH domain protein complexes during development, meiosis and disease.