@article {17020,
	title = {Osteogenesis in in vivo diffusion chamber cultures of human marrow cells},
	journal = {Bone Miner},
	volume = {4},
	number = {4},
	year = {1988},
	note = {Bab, I Passi-Even, L Gazit, D Sekeles, E Ashton, B A Peylan-Ramu, N Ziv, I Ulmansky, M eng Research Support, Non-U.S. Gov{\textquoteright}t Ireland 1988/09/01 Bone Miner. 1988 Sep;4(4):373-86.},
	pages = {373-86},
	type = {Journal Article},
	abstract = {The osteogenic diffusion chamber culture of rodent marrow cells is a well established system. In the present study, marrow cells from children and adult human donors were incubated in diffusion chambers implanted intraperitoneally in athymic mice. After 4 or 8 weeks, the chamber content was examined by light and electron microscopy. Child-cell cultures showed osteogenic tissue consisting of a mineralizing fibrous component and cartilage. Ultrastructurally, the fibrous tissue was similar to osteoid and exhibited osteoblast-like cells and mineralizing nodules. Mineral aggregates were also found in the cartilage. These features in child-cell chambers were similar to those found in control chambers of rabbit marrow cells. Adult-cell chambers showed only unmineralized fibrous tissue. These results render previous findings in animal-cell diffusion chamber systems relevant to the understanding of bone formation in man. It is suggested that the difference between child- and adult-cell chambers reflects an age-related decline in the number of marrow osteoprogenitor cells or their potential to undergo terminal osteogenic differentiation.},
	keywords = {Adult Animals *Bone Marrow Cells Calcification, Culture Humans Mice Mice, Cultured Child *Diffusion Chambers, Electron Minerals/metabolism *Osteogenesis Peritoneal Cavity Rabbits, Inbred BALB C Mice, Nude Microscopy, Physiologic Cartilage/cytology/physiology Cells},
	issn = {0169-6009 (Print) 0169-6009 (Linking)},
	url = {https://www.ncbi.nlm.nih.gov/pubmed/3191291},
	author = {Bab, I. and Passi-Even, L. and Gazit, D. and Sekeles, E. and Ashton, B. A. and Peylan-Ramu, N. and Ziv, I. and Ulmansky, M.}
}
