@article {17107,
	title = {Monitoring of the effect of intervertebral disc nucleus pulposus ablation by MRI},
	journal = {NMR Biomed},
	volume = {23},
	number = {6},
	year = {2010},
	note = {Saar, Galit Zilberman, Yoram Shinar, Hadassah Keinan-Adamsky, Keren Pelled, Gadi Gazit, Dan Navon, Gil eng Research Support, Non-U.S. Gov{\textquoteright}t England 2010/02/23 06:00 NMR Biomed. 2010 Jul;23(6):554-62. doi: 10.1002/nbm.1493.},
	pages = {554-62},
	type = {Journal Article},
	abstract = {In order to investigate intervertebral disc (IVD) degeneration and repair, a quantitative non-invasive tool is needed. Various MRI methods including qCPMG, which yields dipolar echo relaxation time (T(DE)), magnetization transfer contrast (MTC), and (1)H and (2)H double quantum filtered (DQF) MRI were used in the present work to monitor changes in rat IVD after ablation of the nucleus pulposus (NP), serving as a model of severe IVD degeneration. In the intact IVD, a clear distinction between the annulus fibrosus (AF) and the NP is obtained on T(2) and T(DE) weighted images as well as on MTC maps, reflecting the high concentration of ordered collagen fibers in the AF. After ablation of the NP, the distinction between the compartments is lost. T(2) and T(DE) relaxation times are short throughout the disc and MTC is high. (1)H and (2)H DQF signal, which in intact discs is obtained only for the AF, is now observable throughout the tissue. These results indicate that after ablation, there is an ingression of collagen fibers from the AF into the area that was previously occupied by the NP, as was confirmed by histology.},
	keywords = {Animals Collagen/metabolism Female Humans Intervertebral Disc/metabolism/*pathology Intervertebral Disc Degeneration/*pathology Magnetic Resonance Imaging/*methods Rats Rats, Wistar},
	issn = {1099-1492 (Electronic) 0952-3480 (Linking)},
	doi = {10.1002/nbm.1493},
	url = {https://www.ncbi.nlm.nih.gov/pubmed/20175140},
	author = {Saar, G. and Zilberman, Y. and Shinar, H. and Keinan-Adamsky, K. and Pelled, G. and Gazit, D. and Navon, G.}
}
