My current research is focused on understanding the molecular principles of protein aggregation in neurodegeneration and cancer. I am also developping innovative methods for the design of peptides able to target specifically aggregating proteins and inhibit/revert their aggregation.
My research focuses on activating the tumor-suppressor role of the RNF43 protein, to prevent cells over-growth. We are developing and optimizing peptide-based anti-cancer lead compounds that targets RNF43.
My research aim is to understand the molecular mechanism of function of flagella in bacteria. This will allow us to develop a new class of antibiotics, that target the protein-protein interactions between flagellar proteins.