Prof. Assaf Friedler's Lab

Welcome to Assaf Friedler's lab page

ברוכים הבאים לאתר המעבדה של אסף פרידלר

Our lab is a part of the Institute of Chemistry at the Hebrew University of Jerusalem.

We are an interdisciplinary team focusing on the study of protein-protein interactions, peptide inhibitors/activators, peptide and protein chemistry, biophysics, chemical biology and medicinal chemistry (see more).

Prof. Friedler is the Dean of the Faculty of Science of the Hebrew University.

We are looking for talented Chemists, Microbiologists and Bioengineers to come develop next generation cellular agriculture with us!

For more information, Email Assaf!

Follow us on Twitter @FriedlerLab

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Kinase Sensing Based on Protein Interactions at the Catalytic Site, Chem. Eur. J. 2022
Covalent Inhibition of HIV-1 Integrase by N-Succinimidyl Peptides, ChemMedChem 2016
Targeting an Interaction Between Two Disordered Domains by Using a Designed Peptide, Chem. Eur. J. 2020
Differential effects of zinc binding on structured and disordered regions in the multidomain STIL protein, Chem. Sci. 2016
Using peptides to inhibit protein-protein interactions
Osmolytes and crowders regulate aggregation of the cancer-related L106R mutant of the Axin protein, Biophys. J. 2021
Peptides as drug targets
A targeted approach for the synthesis of multi-phosphorylated peptides: a tool for studying the role of, Org. Biomol. Chem. 2019
Electrochemical biosensors based on peptide-kinase interactions at the kinase docking site, Biosens. Bioelectron. 2022
The anti-apoptotic proteins NAF-1 and iASPP interact to drive apoptosis in cancer cells, Chem. Sci. 2019
Highly homologous proteins exert opposite biological activities by using different interaction interfaces, Sci. Rep. 2015
Automated Synthesis of Heavily Phosphorylated Peptides, Eur. J. Org. Chem. 2021
Regulation of ASPP2 Interaction with p53 Core Domain by an Intramolecular Autoinhibitory Mechanism, PLoS ONE 2013
Using peptides to revert the oligomerization of the intrinsically disordered region of STIL
Structured-disordered interactions
A peptide-derived strategy for specifically targeting the mitochondria and ER of cancer cells: a new approach in fighting cancer
Targeting Protein Interaction Hotspots Using Structured and Disordered Chimeric Peptide Inhibitors. ACS Chemical Biology. 2022
Accelerated Multiphosphorylated Peptide Synthesis. OPR&D 2022