@article {1694,
	title = {PADMA-28, a traditional tibetan herbal preparation inhibits the respiratory burst in human neutrophils, the killing of epithelial cells by mixtures of oxidants and pro-inflammatory agonists and peroxidation of lipids},
	journal = {Inflammopharmacology},
	volume = {7},
	number = {1},
	year = {1999},
	pages = {47-62},
	abstract = {Both aqueous and methanolic fractions derived from the Tibetan preparation PADMA-28 (a mixture of 22 plants) used as an anti-atherosclerotic agent, and which is non-cytolytic to a variety of mammalian cells, were found to strongly inhibit (1) the killing of epithelial cells in culture induced by {\textquoteright}cocktails{\textquoteright} comprising oxidants, membrane perforating agents and proteinases; (2) the generation of luminol-dependent chemiluminescence in human neutrophils stimulated by opsonized bacteria; (3) the peroxidation of intralipid (a preparation rich in phopholipids) induced in the presence of copper; and (4) the activity of neutrophil elastase. It is proposed that PADMA-28 might prove beneficial for the prevention of cell damage induced by synergism among pro-inflammatory agonists which is central in the initiation of tissue destruction in inflammatory and infectious conditions.},
	author = {Isaac Ginsburg and Milu Sadovnik and S Sallon and I Milo-Goldzweig and R Mechoulam and A Breuer and D Gibbs and James Varani and S Roberts and E Cleator and N Singh}
}
