@article {4511,
	title = {Chlorhexidine markedly potentiates the oxidants scavenging abilities of Candida albicans},
	journal = {Inflammopharmacology},
	volume = {23},
	number = {271},
	year = {2015},
	pages = {281},
	abstract = {The oxidant scavenging ability (OSA) of catalase-rich Candida albicans is markedly enhanced by chlorhexidine digluconate (CHX), polymyxin B, the bile salt ursodeoxycholate and by lysophosphatidylcholine, which all act as detergents facilitating the penetration of oxidants and their intracellular decomposition. Quantifications of the OSA of Candida albicans were measured by a highly sensitive luminol-dependent chemiluminescence assay and by the Thurman{\textquoteright}s assay, to quantify hydrogen peroxide (H2O2). The OSA enhancing activity by CHX depends to some extent on the media on which candida grew. The OSA of candida treated by CHX was modulated by whole human saliva, red blood cells, lysozyme, cationic peptides and by polyphenols. Concentrations of CHX, which killed over 95\&nbsp;\% of Candida albicans cells, did not affect the cells{\textquoteright} abilities to scavenge reactive oxygen species (ROS). The OSA of Candida cells treated by CHX is highly refractory to H2O2\&nbsp;(50\&nbsp;mM) but is strongly inhibited by hypochlorous acid, lecithin, trypan blue and by heparin. We speculate that similarly to catalase-rich red blood cells, Candida albicans and additional catalase-rich microbiota may also have the ability to scavenge oxidants and thus can protect catalase-negative anaerobes and facultative anaerobes cariogenic streptococci against peroxide and thus secure their survival in the oral cavity.},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/26223507},
	author = {Isaac Ginsburg and Erez Koren and O. Feuerstein and IP. Zogakis and Miri Shalish and S. Gorelik}
}
