@article {3041224,
	title = {A recombinant fungal compound induces anti-proliferative and pro-apoptotic effects on colon cancer cells},
	journal = {Oncotarget},
	volume = {8},
	year = {2017},
	note = {Nimri, Lili Spivak, Orly Tal, Dana Schalling, Dominik Peri, Irena Graeve, Lutz Salame, Tomer M Yarden, Oded Hadar, Yitzhak Schwartz, Betty eng Oncotarget. 2017 Apr 25;8(17):28854-28864. doi: 10.18632/oncotarget.15859.},
	pages = {28854-28864},
	type = {Journal Article},
	abstract = {Finding intracellular pathways and molecules that can prevent the proliferation of colon cancer cells can provide significant bases for developing treatments for this disease. Ostreolysin (Oly) is a protein found in the mushroom Pleurotus ostreatus, and we have produced a recombinant version of this protein (rOly).We measured the viability of several colon cancer cells treated with rOly. Xenografts and syngeneic colon cancer cells were injected into in vivo mouse models, which were then treated with this recombinant protein.rOly treatment induced a significant reduction in viability of human and mouse colon cancer cells. In contrast, there was no reduction in the viability of normal epithelial cells from the small intestine. In the search for cellular targets of rOly, we showed that it enhances the anti-proliferative activity of drugs targeting cellular tubulin. This was accompanied by a reduction in the weight and volume of tumours in mice injected with rOly as compared to their respective control mice in two in vivo models.Our results advance the functional understanding of rOly as a potential anti-cancer treatment associated with pro-apoptotic activities preferentially targeting colon cancer cells.},
	keywords = {Animals Antineoplastic Agents/*therapeutic use Apoptosis/drug effects Cell Proliferation/drug effects Colonic Neoplasms/*drug therapy/pathology Fungal Proteins/genetics/therapeutic use HCT116 Cells Hemolysin Proteins/genetics/*therapeutic use Humans Male, Inbred C57BL Mice, Nude Molecular Targeted Therapy Pleurotus/*immunology Recombinant Proteins/genetics Tubulin/metabolism Tumor Burden/drug effects Xenograft Model Antitumor Assays colon cancer fungal microtubule pro-apoptotic recombinant ostreolysin},
	issn = {1949-2553 (Electronic) 1949-2553 (Linking)},
	doi = {10.18632/oncotarget.15859},
	url = {https://www.ncbi.nlm.nih.gov/pubmed/28416764},
	author = {Nimri, L. and Spivak, O. and Tal, D. and Schalling, D. and Peri, I. and Graeve, L. and Salame, T.M. and O. Yarden and Hadar, Y. and Schwartz, B.}
}
