@article {3041223,
	title = {Mechanisms linking obesity to altered metabolism in mice colon carcinogenesis},
	journal = {Oncotarget},
	volume = {6},
	year = {2015},
	note = {Nimri, Lili Saadi, Janan Peri, Irena Yehuda-Shnaidman, Einav Schwartz, Betty eng Research Support, Non-U.S. Gov{\textquoteright}t Oncotarget. 2015 Nov 10;6(35):38195-209. doi: 10.18632/oncotarget.5561.},
	pages = {38195-209},
	type = {Journal Article},
	abstract = {There are an increasing number of reports on obesity being a key risk factor for the development of colon cancer. Our goal in this study was to explore the metabolic networks and molecular signaling pathways linking obesity, adipose tissue and colon cancer. Using in-vivo experiments, we found that mice fed a high-fat diet (HFD) and injected with MC38 colon cancer cells develop significantly larger tumors than their counterparts fed a control diet. In ex-vivo experiments, MC38 and CT26 colon cancer cells exposed to conditioned media (CM) from the adipose tissue of HFD-fed mice demonstrated significantly lower oxygen consumption rate as well as lower maximal oxygen consumption rate after carbonyl cyanide-4-trifluoromethoxy-phenylhydrazone treatment. In addition, in-vitro assays showed downregulated expression of mitochondrial genes in colon cancer cells exposed to CM prepared from the visceral fat of HFD-fed mice or to leptin. Interestingly, leptin levels detected in the media of adipose tissue explants co-cultured with MC38 cancer cells were higher than in adipose tissue explants cultures, indicating cross talk between the adipose tissue and the cancer cells. Salient findings of the present study demonstrate that this crosstalk is mediated at least partially by the JNK/STAT3-signaling pathway.},
	keywords = {Adenocarcinoma/genetics/*metabolism/pathology Adipose Tissue/*metabolism Adipose Tissue, Animal *Energy Metabolism Gene Expression Regulation, Brown/metabolism Animals *Cell Communication Cell Line, Conditioned/metabolism Diet, High-Fat Disease Models, Inbred BALB C Mice, Inbred C57BL Obesity/etiology/*metabolism Oxygen Consumption *Paracrine Communication STAT3 Transcription Factor/metabolism Signal Transduction Subcutaneous Fat/metabolism Time Factors Tissue Culture Techniques Tumor Burden Jnk/stat3 colon cancer leptin, Neoplastic Inflammation Mediators/metabolism Intra-Abdominal Fat/metabolism JNK Mitogen-Activated Protein Kinases/metabolism Lipid Metabolism/genetics Male Mice, Tumor Cell Proliferation Coculture Techniques Colonic Neoplasms/genetics/*metabolism/pathology Culture Media},
	issn = {1949-2553 (Electronic) 1949-2553 (Linking)},
	doi = {10.18632/oncotarget.5561},
	url = {https://www.ncbi.nlm.nih.gov/pubmed/26472027},
	author = {Nimri, L. and Saadi, J. and Peri, I. and Yehuda-Shnaidman, E. and Schwartz, B.}
}
