@article {3041205,
	title = {An aqueous polysaccharide extract from the edible mushroom Pleurotus ostreatus induces anti-proliferative and pro-apoptotic effects on HT-29 colon cancer cells},
	journal = {Cancer Lett},
	volume = {244},
	year = {2006},
	note = {Lavi, Iris Friesem, Dana Geresh, Shimona Hadar, Yitzhak Schwartz, Betty eng Research Support, Non-U.S. Gov{\textquoteright}t Ireland Cancer Lett. 2006 Nov 28;244(1):61-70. doi: 10.1016/j.canlet.2005.12.007. Epub 2006 Jan 18.},
	pages = {61-70},
	type = {Journal Article},
	abstract = {Anti-proliferative and pro-apoptotic activities of fractions of Pleurotus ostreatus were examined using HT-29 colon cancer cells in vitro. A hot-water-soluble fraction of the mycelium of the liquid cultured mushroom was partially isolated and chemically characterized as a low-molecular-weight alpha-glucan. HT-29 cells were exposed to the different isolates and significant inhibition of proliferation was obtained in a dose-dependent manner. Proliferation inhibition was shown to be the result of apoptotic induction because the pro-apoptotic molecules Bax and cytosolic cytochrome-c were upregulated. Fluorescence-activated cell sorter analyses of polysaccharide-treated HT-29 cells showed a high percentage of Annexin-positive cells. Here, we describe a newly identified low-molecular-weight alpha-glucan with promising anti-tumorigenic properties, and demonstrate its direct effect on colon cancer cell proliferation via induction of programmed cell death.},
	keywords = {Annexin A5/metabolism Antineoplastic Agents/*pharmacology Apoptosis/*drug effects Cell Proliferation/*drug effects Cytochromes c/metabolism Cytosol/enzymology Glucans/*pharmacology HT29 Cells/drug effects Humans Molecular Weight Plant Extracts/*pharmacolo},
	issn = {0304-3835 (Print) 0304-3835 (Linking)},
	doi = {10.1016/j.canlet.2005.12.007},
	url = {https://www.ncbi.nlm.nih.gov/pubmed/16413114},
	author = {Lavi, I. and Friesem, D. and Geresh, S. and Hadar, Y. and Schwartz, B.}
}
