2016
T. Turgeman, Shatil-Cohen, A. , Moshelion, Menachem , Teper-Bamnolker, P. , Skory, C.D. , Lichter, A. , ו Eshel, D.. 2016.
“The Role Of Aquaporins In Ph-Dependent Germination Of Rhizopus Delemar Spores”. Plos One, 11, 3. .
Publisher's Version Extensive research has been conducted in recent decades on the mental health consequences of Palestinians’ exposure to military and political violence. Despite the alarming rates of Palestinian youth exposure to community violence (ECV), there is a serious dearth of research on the effects of this pattern of exposure. The current study focused on the development of post-traumatic stress disorder (PTSD) symptoms among Palestinian adolescents as a result of their ECV. The study also examines the ability of perceived support from family and teachers to moderate the relationship between ECV and PTSD symptoms, and the involvement of demographic and socioeconomic variables in explaining this development. A sample of 1930 Palestinian secondary school students, aged 12–19, from the West Bank and East Jerusalem, answered questionnaires. Data analysis used univariate, bivariate, and multivariate methods, including SEM. The prevalence of PTSD symptoms was predicted by past year ECV, family support, teacher support, residential density, parents’ education, age, and gender. SEM analysis validated additional relationship paths between variables. Results are discussed, suggesting future research with theoretical and practical implications.
The past decade has witnessed many advances in the understanding of sirtuin biology and related regulatory circuits supporting the capacity of these proteins to serve as energy-sensing molecules that contribute to healthspan in various tissues, including articular cartilage. Hence, there has been a significant increase in new investigations that aim to elucidate the mechanisms of sirtuin function and their roles in cartilage biology, skeletal development, and pathologies such as osteoarthritis (OA), rheumatoid arthritis (RA), and intervertebral disc degeneration (IVD). The majority of the work carried out to date has focused on SIRT1, although SIRT6 has more recently become a focus of some investigations. In vivo work with transgenic mice has shown that Sirt1 and Sirt6 are essential for maintaining cartilage homeostasis and that the use of sirtuin-activating molecules such as resveratrol may have beneficial effects on cartilage anabolism. Current thinking is that SIRT1 exerts positive effects on cartilage by encouraging chondrocyte survival, especially under stress conditions, which may provide a mechanism supporting the use of sirtuin small-molecule activators (STACS) for future therapeutic interventions in OA and other degenerative pathologies of joints, especially those that involve articular cartilage.
Vaccination is recognized to be the most cost-effective means of preventing, controlling, and even eradicating infectious diseases. Conventional poultry are vaccinated through various routes including eye/nose drops, drinking water, vent brush, or injection. Efficient vaccination is an essential part of any good poultry management.The bursa of Fabricius is intimately connected to the cloaca and the intestinal system. It is well-known as a primary lymphoid organ in the chicken and a major channel through which environmental antigens stimulate the immune system. In this study we tested whether direct instillation of various viral vaccines and antigens into the cloaca (per bursam), could stimulate higher antibody titers and generate improved protection. Despite the very rapid absorption of the vaccines or antigens from the cloaca to the lumen of the Bursa of Fabricius, per bursam inoculation failed to generate a satisfactory immune response. In contrast conventional administration of live or inactivated commercial vaccines led to an acceptable level of seroconversion and protection against challenge.An interesting finding in this study was the fact that administration of a single priming dose of antigenic material at age 1 or 5 days, did not improve the response to a second administration at 14 days of age as expected. Instead, in most cases there was a reduced serum antibody response suggesting the induction of tolerance. This was true for all routes of administration (intramuscular, per ocular and per bursam) and for all formulations of vaccine.The current study reveals: 1) no advantage for direct application of live or inactivated vaccines or antigens into the bursa of Fabricius compared to common routes of vaccination, 2) that apparent desensitization or tolerance effects have important implications for poultry management, since in many countries, vaccination of day old chicks is compulsory or a well-accepted part of flock vaccination.According to our results, early vaccination can in fact reduce or inhibit a secondary immune response to subsequent vaccination and increase susceptibility to disease agents.
Anat Perry, Lwi, Sandy , Verstaen, Alice , Dewar, Callum , W., Levenson Robert , ו Knight, Robert T.. 2016.
“The Role Of The Orbitofrontal Cortex In Regulation Of Interpersonal Space: Evidence From Frontal Lesion And Frontotemporal Dementia Patients”. Social Cognitive & Affective Neuroscience, 11, Pp. 1894-1901. .
Publisher's Version תקציר Interpersonal distance is central to communication and complex social behaviors but the neural correlates of interpersonal distance preferences are not defined. Previous studies suggest that damage to the orbitofrontal cortex (OFC) is associated with impaired interpersonal behavior. To examine whether the OFC is critical for maintaining appropriate interpersonal distance, we tested two groups of patients with OFC damage: Patients with OFC lesions and patients with behavioral variant frontotemporal dementia. These two groups were compared to healthy controls and to patients with lesions restricted to the dorsolateral prefrontal cortex. Only patients with OFC damage showed abnormal interpersonal distance preferences, which were significantly different from both controls and patients with dorsolateral prefrontal damage. The comfortable distances these patients chose with strangers were significantly closer than the other groups and resembled distances normally used with close others. These results shed light on the role of the OFC in regulating social behavior and may serve as a simple diagnostic tool for dementia or lesion patients.
A. Shemesh, Levin, A. , Katzenell, V. , Itzhak, J.B. , Avraham, Z. , Levinson, O. , ו Solomonov, M.. 2016.
“Root Anatomy And Root Canal Morphology Of Mandibular Canines In Israeli Population”. Refuʼat Ha-Peh Ṿeha-Shinayim (1993), 33, Pp. 19–23, 60. .
Publisher's Version Idan Efroni, Mello, Alison , Nawy, Tal , Ip, Pui-Leng , Rahni, Ramin , DelRose, Nicholas , Powers, Ashley , Satija, Rahul , ו Birnbaum, Kenneth D.. 2016.
“Root Regeneration Triggers An Embryo-Like Sequence Guided By Hormonal Interactions”, 165, 7, Pp. 1721 - 1733. .
Publisher's Version תקציר SummaryPlant roots can regenerate after excision of their tip, including the stem cell niche. To determine which developmental program mediates such repair, we applied a combination of lineage tracing, single-cell RNA sequencing, and marker analysis to test different models of tissue reassembly. We show that multiple cell types can reconstitute stem cells, demonstrating the latent potential of untreated plant cells. The transcriptome of regenerating cells prior to stem cell activation resembles that of an embryonic root progenitor. Regeneration defects are more severe in embryonic than in adult root mutants. Furthermore, the signaling domains of the hormones auxin and cytokinin mirror their embryonic dynamics and manipulation of both hormones alters the position of new tissues and stem cell niche markers. Our findings suggest that plant root regeneration follows, on a larger scale, the developmental stages of embryonic patterning and is guided by spatial information provided by complementary hormone domains.
Lior Feldman, Galili, Eran , Cohen, Yuval , Hartal, Michael , Yavnai, Nirit , ו Netzer, Itamar . 2016.
“Routine Chlorhexidine Gluconate Use Onboard Navy Surface Vessels To Reduce Infection: A Cluster Randomized Controlled Trial”. American Journal Of Infection Control.
Imri Oz, Eyal, Shalev , Yoseph, Yechieli , Ittai, Gavrieli , Elad, Levanon , ו Haim, Gvirtzman . 2016.
“Salt Dissolution And Sinkhole Formation: Results Of Laboratory Experiments”, Pp. 1–17. doi:10.1002/2016JF003902.Received.
A detailed understanding of the molecular mechanisms whereby ubiquitin (Ub) recognizes enzymes in the Ub proteasome system is crucial for understanding the biological function of Ub. Many structures of Ub complexes have been solved and, in most cases, reveal a large structural epitope on a common face of the Ub molecule. However, owing to the generally weak nature of these interactions, it has been difficult to map in detail the functional contributions of individual Ub side chains to affinity and specificity. Here we took advantage of Ub variants (Ubvs) that bind tightly to particular Ub-specific proteases (USPs) and used phage display and saturation scanning mutagenesis to comprehensively map functional epitopes within the structural epitopes. We found that Ubvs that bind to USP2 or USP21 contain a remarkably similar core functional epitope, or ``hot spot,'' consisting mainly of positions that are conserved as the wild type sequence, but also some positions that prefer mutant sequences. The Ubv core functional epitope contacts residues that are conserved in the human USP family, and thus it is likely important for the interactions of Ub across many family members.
In 2014 New Perspectives Theatre Company staged the first adaptation on the stage of a short story by Saul Bellow, “Him with His Foot in His Mouth.” The changes made to the story in its adaptation for the stage inform our understanding of the comic effect of the story, particularly in relation to the different endings involved. The dynamic of the story depends upon the deployment of two different concepts of comedy — as the expression of an aggressive, materialistic society (Freud, The Joke in Relation to the Unconscious) or as a means of reforming society in green comedy (Northrop Frye, The Anatomy of Criticism). The story focusses upon the legitimate irresponsibility of comedy, and on the relation of comedy to freedom, defending it as a social and even a sacred good. The one-liners uttered by the hero exemplify comedy of a corrective nature, offering a healthy critique of social behavior, particularly in terms of the relation of art to money, and contest Freud’s theory as tainted by its social context and economic basis. | January 2016: Judie Newman is Professor of American Studies at the University of Nottingham. Her recent publications include Utopia and Terror in Contemporary American Fiction (Routledge 2013), Public Art, Memorials, and Atlantic Slavery (with C-M Bernier, Routledge, 2009) and Fictions of America: Narratives of Global Empire (Routledge, 2007). Together with Celeste-Marie Bernier and Matthew Pethers she has edited the Edinburgh Companion to Nineteenth-Century American Letters and Letter-Writing (Edinburgh University Press, forthcoming in 2016). |
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According to Saul Bellow (1915–2005), one of the main responsibilities of the novelist is to expose “the center” and to adjudicate among the many explanations, rationalizations, defenses, and subterfuges that constitute modern life. Bellow cautions against the “noise” of modern life because, he believes, it distracts one from the center, from the essence of human experience. Amidst the chaos of modern life, Bellow’s fiction — novels and short stories of contemplation and of meditated reflection — is a stay against confusion. The “Introduction to the Forum” establishes the context for a discussion of Bellow’s works and frames the issues raised in the individual articles in the Forum. |
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Saul Bellow’s fiction is decidedly philosophic, particularly as he celebrates depth of personhood in his characters while denigrating superficiality. The discursive action of this focus on personal depth involves the idea of soul, which, for Bellow, resonates in individual characters in his fiction as well as in the “character” of culture, usually viewed in historical decline, one of his preoccupations. This essay examines this dual understanding of soul — as a function of individual character and as the “character” of culture — in two of Bellow’s novels: Humboldt’s Gift (1975) and Ravelstein (2000). Both are concerned with the tension between the grandeur of art and ideas and the depredations of rising commercial culture in America. In Humboldt’s Gift, Bellow offers an initial view of the messy genius of a great intellectual, while in Ravelstein the persona of a great intellectual is fully developed and even more explicitly presented in terms of the relation between such “greatness of soul” and cultural and intellectual decline in late-capitalism. In both novels, an aesthetic of great personhood works through characterization, with “greatness” revealing itself metonymically as aestheticized relational energy and in the genius for seeing revealed essences. In the characters of Von Humboldt Fleisher and Abe Ravelstein, characters based on two of Saul Bellow’s teachers and intellectual heroes, Delmore Schwartz and Allan Bloom, Bellow explores a type of intellectual heroism, the loss of which, he believes, has severe, even catastrophic, cultural consequences. January 2016: Willis Salomon is Associate Professor of English at Trinity University, San Antonio, where he teaches Early Modern English poetry and prose. His previous work on Bellow has appeared in A Political Companion to Saul Bellow, ed. Lee Trepanier (Lexington: University of Kentucky Press, 2013) and The Saul Bellow Journal. |
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Philippe Drobinski, Da Silva, Nicolas , Panthou, Gérémy , Bastin, Sophie , Muller, Caroline , Ahrens, Bodo , Borga, Marco , Conte, Dario , Fosser, Giorgia , Giorgi, Filippo , Güttler, Ivan , Kotroni, Vassiliki , Li, Laurent , Morin, Efrat , Önol, Bari$\backslash$cs , Quintana-Segui, Pere , Romera, Raquel , ו Torma, Csaba Zsolt . 2016.
“Scaling Precipitation Extremes With Temperature In The Mediterranean: Past Climate Assessment And Projection In Anthropogenic Scenarios”. Climate Dynamics. doi:10.1007/s00382-016-3083-x.
Publisher's Version תקציר In this study we investigate the scaling of precipitation extremes with temperature in the Mediterranean region by assessing against observations the present day and future regional climate simulations performed in the frame of the HyMeX and MED-CORDEX programs. Over the 1979–2008 period, despite differences in quantitative precipitation simulation across the various models, the change in precipitation extremes with respect to temperature is robust and consistent. The spatial variability of the temperature–precipitation extremes relationship displays a hook shape across the Mediterranean, with negative slope at high temperatures and a slope following Clausius–Clapeyron (CC)-scaling at low temperatures. The temperature at which the slope of the temperature–precipitation extreme relation sharply changes (or temperature break), ranges from about 20 \$\backslash$textdegree\C in the western Mediterranean to \textless10 \$\backslash$textdegree\C in Greece. In addition, this slope is always negative in the arid regions of the Mediterranean. The scaling of the simulated precipitation extremes is insensitive to ocean–atmosphere coupling, while it depends very weakly on the resolution at high temperatures for short precipitation accumulation times. In future climate scenario simulations covering the 2070–2100 period, the temperature break shifts to higher temperatures by a value which is on average the mean regional temperature change due to global warming. The slope of the simulated future temperature–precipitation extremes relationship is close to CC-scaling at temperatures below the temperature break, while at high temperatures, the negative slope is close, but somewhat flatter or steeper, than in the current climate depending on the model. Overall, models predict more intense precipitation extremes in the future. Adjusting the temperature–precipitation extremes relationship in the present climate using the CC law and the temperature shift in the future allows the recovery of the temperature–precipitation extremes relationship in the future climate. This implies negligible regional changes of relative humidity in the future despite the large warming and drying over the Mediterranean. This suggests that the Mediterranean Sea is the primary source of moisture which counteracts the drying and warming impacts on relative humidity in parts of the Mediterranean region.
Adam Nir, Ben-David, Adi , Bogler, Ronit , Inbar, Dan , ו Zohar, Anat . 2016.
“School Autonomy And 21St Century Skills In The Israeli Educational System”. International Journal Of Educational Management, 30, 7, Pp. 1231 - 1246. .
Publisher's Version תקציר Purpose The purpose of this paper is to analyze two parallel processes in the Israeli educational system: first, the idea of school autonomy, exploring its origins and its pedagogical implications and effectiveness; and second, the development of the progressive education evident mainly in the cognitive domain of twenty-first century skills (21st CS), focussing on fostering “deep knowledge” and children’s thinking skills. The manuscript explores the various “waves” of progressive pedagogies that have taken place in the Israeli school system over the years, describing and analyzing the processes that characterize them. Design/methodology/approach Based on a historical perspective, the paper describes chronologically the main developments related to school autonomy and 21st CS policy initiatives, based on a literature review and analysis of policy documents. Findings The review indicates that the Israeli educational system is still caught in the “centralization trap,” inhibiting major changes in the patterns of central control and degrees of freedom granted to school-level educators. As for school pedagogy, it is evident that most of the changes in pedagogy suggested by the numerous policy documents over the years have not resulted in sustainable, system-wide change. In both issues a large disparity is evident between declarations about innovative pedagogies and school autonomy and their actual implementation. Originality/value The review reflects the idiosyncratic articulation of policy plans conducted by the Ministry of Education, producing discrepancies and incongruences at the school level. Some implications of the “declarative culture” created are further discussed.
