פרסומים

2017
Saʿar Ganor ו Kreimerman, Igor . 2017. “Going To The Bathroom At Lachish”. Biblical Archaeology Review, 43, 6, Pp. 56–60.
Liat Kozma. 2017. “Going Transnational : On Mainstreaming Middle East Gender Studies”. International Journal Of Middle Eastern Studies, 48, Pp. 574-577.
Olivia Smith Spicer, Zmora, Nilli , Wong, Ten-Tsao , Golan, Matan , Levavi-Sivan, Berta , Gothilf, Yoav , ו Zohar, Yonathan . 2017. “The Gonadotropin-Inhibitory Hormone (Lpxrfa) System's Regulation Of Reproduction In The Brain-Pituitary Axis Of The Zebrafish (Danio Rerio)”. Biol Reprod, 96, 5, Pp. 1031-1042. doi:10.1093/biolre/iox032. תקציר
Gonadotropin-inhibitory hormone (GNIH) was discovered in quail with the ability to reduce gonadotropin expression/secretion in the pituitary. There have been few studies on GNIH orthologs in teleosts (LPXRFamide (Lpxrfa) peptides), which have provided inconsistent results. Therefore, the goal of this study was to determine the roles and modes of action by which Lpxrfa exerts its functions in the brain-pituitary axis of zebrafish (Danio rerio). We localized Lpxrfa soma to the ventral hypothalamus, with fibers extending throughout the brain and to the pituitary. In the preoptic area, Lpxrfa fibers interact with gonadotropin-releasing hormone 3 (Gnrh3) soma. In pituitary explants, zebrafish peptide Lpxrfa-3 downregulated luteinizing hormone beta subunit and common alpha subunit expression. In addition, Lpxrfa-3 reduced gnrh3 expression in brain slices, offering another pathway for Lpxrfa to exert its effects on reproduction. Receptor activation studies, in a heterologous cell-based system, revealed that all three zebrafish Lpxrfa peptides activate Lpxrf-R2 and Lpxrf-R3 via the PKA/cAMP pathway. Receptor activation studies demonstrated that, in addition to activating Lpxrf receptors, zebrafish Lpxrfa-2 and Lpxrfa-3 antagonize Kisspeptin-2 (Kiss2) activation of Kisspeptin receptor-1a (Kiss1ra). The fact that kiss1ra-expressing neurons in the preoptic area are innervated by Lpxrfa-ir fibers suggests an additional pathway for Lpxrfa action. Therefore, our results suggest that Lpxrfa may act as a reproductive inhibitory neuropeptide in the zebrafish that interacts with Gnrh3 neurons in the brain and with gonadotropes in the pituitary, while also potentially utilizing the Kiss2/Kiss1ra pathway.
Olivia Smith Spicer, Zmora, Nilli , Wong, Ten-Tsao , Golan, Matan , Levavi-Sivan, Berta , Gothilf, Yoav , ו Zohar, Yonathan . 2017. “The Gonadotropin-Inhibitory Hormone (Lpxrfa) System's Regulation Of Reproduction In The Brain–Pituitary Axis Of The Zebrafish (Danio Rerio)†”. Biology Of Reproduction, 96, 5, Pp. 1031-1042. doi:10.1093/biolre/iox032. Publisher's Version תקציר
Gonadotropin-inhibitory hormone (GNIH) was discovered in quail with the ability to reduce gonadotropin expression/secretion in the pituitary. There have been few studies on GNIH orthologs in teleosts (LPXRFamide (Lpxrfa) peptides), which have provided inconsistent results. Therefore, the goal of this study was to determine the roles and modes of action by which Lpxrfa exerts its functions in the brain–pituitary axis of zebrafish (Danio rerio). We localized Lpxrfa soma to the ventral hypothalamus, with fibers extending throughout the brain and to the pituitary. In the preoptic area, Lpxrfa fibers interact with gonadotropin-releasing hormone 3 (Gnrh3) soma. In pituitary explants, zebrafish peptide Lpxrfa-3 downregulated luteinizing hormone beta subunit and common alpha subunit expression. In addition, Lpxrfa-3 reduced gnrh3 expression in brain slices, offering another pathway for Lpxrfa to exert its effects on reproduction. Receptor activation studies, in a heterologous cell-based system, revealed that all three zebrafish Lpxrfa peptides activate Lpxrf-R2 and Lpxrf-R3 via the PKA/cAMP pathway. Receptor activation studies demonstrated that, in addition to activating Lpxrf receptors, zebrafish Lpxrfa-2 and Lpxrfa-3 antagonize Kisspeptin-2 (Kiss2) activation of Kisspeptin receptor-1a (Kiss1ra). The fact that kiss1ra-expressing neurons in the preoptic area are innervated by Lpxrfa-ir fibers suggests an additional pathway for Lpxrfa action. Therefore, our results suggest that Lpxrfa may act as a reproductive inhibitory neuropeptide in the zebrafish that interacts with Gnrh3 neurons in the brain and with gonadotropes in the pituitary, while also potentially utilizing the Kiss2/Kiss1ra pathway.
Jale Tosun, Jordan, Andrew , ו Maor, Moshe . 2017. “ Governing Climate Change: The (Dis)Proportionality Of Policy Responses ”. Journal Of Environmental Policy & Planning , 19, 6, Pp. 596-598.
Tosun, Jale, Jordan, Andrew , ו Maor, Moshe . 2017. “Governing Climate Change: The (Dis)Proportionality Of Policy Responses”. Journal Of Environmental Policy & Planning, 19, 6, Pp. 596-598. doi:10.1080/1523908X.2017.1354451. Publisher's Version
Policy Dynamics
Shalhevet Attar-Schwartz ו Buchanan, Ann . 2017. “Grandparent-Adolescent Relationship”. Encyclopedia Of Adolescence, Pp. 1–16.
Shalhevet Attar-Schwartz ו Buchanan, Ann . 2017. “Grandparent-Adolescent Relationship”. Encyclopedia Of Adolescence, Pp. 1–16.
Rebecca Naomi Davies, Werner, Shirli , ו Sinai, Amanda . 2017. “Guardianship And Supported Decision Making In Israel”. Advances In Mental Health And Intellectual Disabilities, 11, Pp. 54–64. doi:10.1108/AMHID-11-2016-0040. תקציר
Purpose: Recent research has promoted the use of supported decision making, in contrast to historical methods of substitute decision making when working with people with intellectual disabilities. In Israel, people with disabilities are protected by the Legal Capacity and Guardianship Law of 1962, which was amended in 2016. The purpose of this paper is to consider how these recent changes are perceived by the professionals in Israel. Design/methodology/approach: Professionals with experience in policy making, law, social work and with direct experience working with people with intellectual disabilities (ID) were interviewed using semi-structured interviews and one focus group. Interviews were recorded and subsequently coded and analysed qualitatively. Findings: Two major themes were identified. These were: the law and its phrasing, and changing culture. Findings highlight the process of change within guardianship law and practice and the challenges in implementation encountered so far and anticipated in the future. Originality/value: Guardianship laws are changing in many states and the challenges to implementation of supported decision-making in these countries have been echoed in this study. Functional models to allow implementation of supported decision-making have not yet been strongly evidenced. It is hoped that this research may provide a springboard for further study into legal capacity and guardianship issues in Israel and elsewhere.
O. Ramos-Lopez, Milagro, F.I. , Allayee, H. , Chmurzynska, A. , Choi, M.S. , Curi, R. , De Caterina, R. , Ferguson, L.R. , Goni, L. , Kang, J.X. , Kohlmeier, M. , Marti, A. , Moreno, L.A. , Pérusse, L. , Prasad, C. , Qi, L. , Reifen, Ram , Riezu-Boj, J.I. , San-Cristobal, R. , Santos, J.L. , ו Martínez, J.A. . 2017. “Guide For Current Nutrigenetic, Nutrigenomic, And Nutriepigenetic Approaches For Precision Nutrition Involving The Prevention And Management Of Chronic Diseases Associated With Obesity”. . Publisher's Version תקציר
Chronic diseases, including obesity, are major causes of morbidity and mortality in most countries. The adverse impacts of obesity and associated comorbidities on health remain a major concern due to the lack of effective interventions for prevention and management. Precision nutrition is an emerging therapeutic approach that takes into account an individual's genetic and epigenetic information, as well as age, gender, or particular physiopathological status. Advances in genomic sciences are contributing to a better understanding of the role of genetic variants and epigenetic signatures as well as gene expression patterns in the development of diverse chronic conditions, and how they may modify therapeutic responses. This knowledge has led to the search for genetic and epigenetic biomarkers to predict the risk of developing chronic diseases and personalizing their prevention and treatment. Additionally, original nutritional interventions based on nutrients and bioactive dietary compounds that can modify epigenetic marks and gene expression have been implemented. Although caution must be exercised, these scientific insights are paving the way for the design of innovative strategies for the control of chronic diseases accompanying obesity. This document provides a number of examples of the huge potential of understanding nutrigenetic, nutrigenomic, and nutriepigenetic roles in precision nutrition.
guiding_the_real_temple-the_construction_of_authenticity_-yemima_cohen.pdf
Meirav Pevsner-Fischer, Blacher, Eran , Tatirovsky, Evgeny , Ben-Dov, Iddo Z, ו Elinav, Eran . 2017. “The Gut Microbiome And Hypertension”. Current Opinion In Nephrology And Hypertension, 26, Pp. 1–8.

cover hebrewThe Stage as a Temporary Home takes us through the fascinating stages in the life and career of the duo Shimen Dzigan and Isroel Shumacher, over the course of half a century - from the beginning of their work at the Ararat avant-garde Yiddish theater in Łodz, Poland, and to their Warsaw theater, where they produced bold, groundbreaking political satire. The book further discusses their wanderings through the Soviet Union during the Second World War and their attempt to revive Jewish culture in Poland after the Holocaust, and finally describes their arrival in Israel, first as guest performers and later as permanent residents. Despite the restrictions on Yiddish actors in Israel, the duo insisted on performing in their own language and succeeded in translating the new Israeli reality into unique and timely satire. In the 1950s, they voiced a political and cultural critique of a kind that was not heard on any of the Hebrew stages. After they parted ways, and following the death of Shumacher in 1961, Dzigan continued to perform on his own and with other Israeli artists until his death in 1980.

The book is based on rare recordings, transcriptions, programs, personal diaries, letters, photographs, oral testimonies, and critical articles, all of which come together to create the first critical portrait of this extraordinary duo. The book also examines their art, the connection between theater and politics, and the complex relationship between majority culture and minority language.

The study includes several valuable indexes: of titles of programs and plays, of the artists who participated in them, of writers and the drafts they wrote, of actors and the programs in which they participated, and a general name index. The book also includes a facsimile of the manuscript Der Nayer Dybbuk [The New Dybbuk].

 

 

Reviews of the book on Dzigan and Shumacher

Ruthie Abeliovich, Gal-Ed Journal, April 2021 [Hebrew]

Mihail Krutikov, "Dzigan and Shumacher: Actors on the Stage of Jewish Exile", The Yiddish Daily Forward, April 2021.[Yiddish]

Ellen Presser, "Laurel und Hardy auf Jiddisch", Jüdische Allgemeine, 19.5.2021 [German]

Avrom Lichtenbaum, Entrevista con Diego Rotman, YIWO Radio, March 2021 [Spanish]

Vassili Schedrin, "DZIGAN AND SHUMACHER: BEFORE “CABARET” AND “SCHINDLER’S LIST.” AN INTERVIEW WITH DIEGO ROTMAN", The Theatre Times, September 2020
Adi Mahalel, East European Jewish Affairs, December 2019
Raphael Cohen Almagor, Tamar Hermann, Hanna Herzog, Sam Lehman-Wilzig, and Ruvi Ziegler, Israel Studies Review 34,  September 2019
Arieh Sover, Humor Mekuvan - Academic Online Journal of Humor Research 11, December 2018 [Hebrew]
Michal Zamir, Haaretz, July 2018 [Hebrew]
Hagai Hitron, Haaretz, June 2018 [Hebrew]
Yaad Biran, Haaretz, March 2018 [Hebrew]
Itay Zutra, The Jewish Post & News, March 2018
Gabi Zohar, Radio 104.5, interviewing Diego Rotman, February 2018, [Hebrew]
Beni Mer, "Diego Rotman Describes the Art of Dzigan and Shumacher", The Yiddish Daily Forward, June 2017, [Yiddish]

 

Launching Events

Susana Skura, Cynthya Gabbay, Diego Rotman, Launching event in Spanish, at Simania/LAJSA - Latin American Jewish Studies Association

Diego Rotman, Dr. Diego Rotman: "Di geshikhte fun nisht farbetene gest: Dzigan un Shumacher in Yisroel" (Scholem-Alejchem-Vortrag 2021) [Yiddish]

Zehavit Stern, Ruthi Abeliovich, Galit Hasan-Rokem, Elyakim Rubinstein, Shmulik Vircer-Atsmon, Launching of the book in Hebrew, Hansen House

 

Elyakim Kislev. 2017. “Happiness, Post-Materialist Values, And The Unmarried”. Journal Of Happiness Studies, Pp. 1-23. . Publisher's Version תקציר
With the rise of individualism and post-materialist values comes the fall in the importance of marriage. However, it is still not clear how these two processes affect each other in terms of individuals’ wellbeing and happiness. Thus, the aim of this paper is to gain a better understanding of how happiness may be moderated by post-materialist values among different groups of marital status: never married, divorced/separated, widowed, married, and cohabiting individuals. Through executing a multilevel analysis on data from the European Social Survey between 2002 and 2014, this paper demonstrates a clear relationship between post-materialist values and levels of happiness. Moreover, it is shown that holding post-materialist views provides greater levels of happiness for singles than it does for cohabiters and married individuals, raising questions about the relationship between marriage and happiness in a post-materialist era.
Botao Ji, Panfil, Yossef E, ו Banin, Uri . 2017. “Heavy-Metal-Free Fluorescent Znte/Znse Nanodumbbells”. Acs Nano, 11, 7, Pp. 7312-7320. . Publisher's Version תקציר

Abstract Image

For visible range emitting particles, which are relevant for display and additional applications, Cd-chalcogenide nanocrystals have reached the highest degree of control and performance. Considering potential toxicity and regulatory limitations, there is a challenge to successfully develop Cd-free emitting nanocrystals and, in particular, heterostructures with desirable properties. Herein, we report a colloidal synthesis of fluorescent heavy-metal-free Zn-chalcogenide semiconductor nanodumbbells (NDBs), in which ZnSe tips were selectively grown on the apexes of ZnTe rods, as evidenced by a variety of methods. The fluorescence of the NDBs can be tuned between ∼500 and 585 nm by changing the ZnSe tip size. The emission quantum yield can be greatly increased through chloride surface treatment and reaches more than 30%. Simulations within an effective-mass-based model show that the hole wave function is spread over the ZnTe nanorods, while the electron wave function is localized on the ZnSe tips. Quantitative agreement for the red-shifted emission wavelength is obtained between the simulations and the experiments. Additionally, the changes in radiative lifetimes correlate well with the calculated decrease in electron–hole overlap upon growth of larger ZnSe tips. The heavy-metal-free ZnTe/ZnSe NDBs may be relevant for optoelectronic applications such as displays or light-emitting diodes.

Ofra Tirosh-Becker. 2017. “Hebrew And Judeo-Arabic In Homilies For Bar Mitzva From Ghardaia (Algeria)”. Language Studies 17-18: 611-636. (In Hebrew). תקציר

ע' תירוש-בקר, " עברית וערבית בדרושים לבר מצווה מגרדאיה (אלג'יריה)", מחקרים בלשון יז-יח: ספר היובל לאהרן ממן, בעריכת יוחנן ברויאר, שמואל פסברג ועפרה תירוש-בקר, ירושלים תשע"ז, עמ' 638-611.

Tirosh-Becker 2017. Language Studies 17-18, 611-636.pdf
O. Tirosh-Becker. 2017. “Hebrew And Judeo-Arabic In Homilies For Bar Mitzva From Ghardaia (Algeria) (In Hebrew)”. Language Studies, 17-18, Pp. 611-636.
Igor Kreimerman. 2017. “The Hellenistic Conquest Of Israel And Its Influence On The Settlement Of The Hill Country And The Shephelah”. New Studies On The Archaeology Of Jerusalem And Its Region.
Rachel Goldberg, Sonnenblick, Amir , Hermano, Esther , Hamburger, Tamar , Meirovitz, Amichay , Peretz, Tamar , ו Elkin, Michael . 2017. “ Heparanase Augments Insulin Receptor Signaling In Breast Carcinoma ”. Oncotarget. . Publisher's Version
Noam Erez, Hubel, Einav , Avraham, Roy , Cohen, Raya , Fishman, Sigal , Bantel, Heike , Manns, Michael , Tirosh, Boaz , Zvibel, Isabel , ו Shibolet, Oren . 2017. “Hepatic Amiodarone Lipotoxicity Is Ameliorated By Genetic And Pharmacological Inhibition Of Endoplasmatic Reticulum Stress.”. Toxicological Sciences : An Official Journal Of The Society Of Toxicology, 159, 2, Pp. 402–412. doi:10.1093/toxsci/kfx143. תקציר
Amiodarone is a commonly used antiarrhythmic drug and can cause liver steatosis. We investigated the role of endoplasmic reticulum (ER) stress/unfolded protein response in the pathogenesis of amiodarone-induced steatosis. Amiodarone-induced liver injury was obtained by 1 intraperitoneal injection to wild-type (WT) or C/EBP homologous protein knock-out mice (Ddit3-/-). Amiodarone directly reduced intracellular ATP and Ca2+ in hepatocytes invitro, inducing ER stress and lipid accumulation. In vivo, amiodarone-driven liver damage and lipid accumulation was accompanied by activation of ER stress/unfolded protein response, as demonstrated by up-regulation of genes encoding key ER stress mediators and by phosphorylation of eIF2$\alpha$. In contrast to WT mice, Ddit3-/- mice were protected from amiodarone-induced ER stress and lipid accumulation. Importantly, amiodarone-induced lipid accumulation was not mediated by de novo hepatic lipogenesis, increased adipose tissue lipolysis or increased hepatic uptake of triglycerides or free fatty acids. Rather, amiodarone strongly increased hepatic mRNA expression of lipid droplet proteins, particularly Cidea and Cidec, in WT, but less so in Ddit3-/- mice, suggesting a link between ER stress and increased triglyceride storage. Moreover, while insulin attenuated amiodarone-induced phosphorylation of hormone sensitive lipase (HSL) in WT, it did not affect pHSL in Ddit3-/-, indicating increased lipolysis and therefore reduced lipid accumulation in these mice. Finally, ER stress attenuation using 2 different pharmacological chaperones reduced lipid accumulation, accompanied by reduced mRNA expression of Cidec. In conclusion, amiodarone-induced ER stress drives liver steatosis and may be considered for therapeutic targeting.